C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease

This large, prospective study calls into question the value of the C-reactive protein (CRP) concentration in the prediction of coronary events. In contrast to previous research, this study found that the strength of the CRP concentration as a predictor is relatively moderate and that it adds little...

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Vydáno v:The New England journal of medicine Ročník 350; číslo 14; s. 1387 - 1397
Hlavní autoři: Danesh, John, Wheeler, Jeremy G, Hirschfield, Gideon M, Eda, Shinichi, Eiriksdottir, Gudny, Rumley, Ann, Lowe, Gordon D.O, Pepys, Mark B, Gudnason, Vilmundur
Médium: Journal Article
Jazyk:angličtina
Vydáno: Boston, MA Massachusetts Medical Society 01.04.2004
Témata:
Aged
Biological and medical sciences
Biomarkers - blood
Blood Sedimentation
C-Reactive Protein - analysis
Cardiology. Vascular system
Cardiovascular disease
Case-Control Studies
Coronary Disease - blood
Coronary heart disease
Drug therapy
Female
General aspects
Heart
Heart attacks
Humans
Inflammation - blood
Male
Medical sciences
Meta-Analysis as Topic
Middle Aged
Odds Ratio
Prospective Studies
Proteins
Risk
Risk Factors
Systematic review
von Willebrand Factor - analysis
Womens health
Reykjavik Iceland
Iceland
Medicine
Acute phase protein
Prediction
Biological marker
Cardiovascular disease
Biological indicator
Inflammation
Predictive factor
C reactive protein
Coronary heart disease
ISSN:0028-4793, 1533-4406, 1533-4406
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Shrnutí:This large, prospective study calls into question the value of the C-reactive protein (CRP) concentration in the prediction of coronary events. In contrast to previous research, this study found that the strength of the CRP concentration as a predictor is relatively moderate and that it adds little to the predictive value of standard coronary risk factors, such as the cholesterol concentration, smoking status, and blood pressure. This large study calls into question the value of CRP in the prediction of coronary events. Since atherosclerosis may, in part, be an inflammatory disease, 1 circulating factors related to inflammation may be predictors of cardiovascular disease in general populations. 2 A recent statement from the Centers for Disease Control and Prevention and the American Heart Association concluded that it is reasonable to measure C-reactive protein, a sensitive circulating marker of inflammation, as an adjunct to the measurement of established risk factors in order to assess the risk of coronary heart disease. 3 The report acknowledged, however, that the epidemiologic data to support this view were not entirely consistent and recommended that larger prospective studies be conducted to improve . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa032804