Targeting mechanisms of tailed bacteriophages

Phages differ substantially in the bacterial hosts that they infect. Their host range is determined by the specific structures that they use to target bacterial cells. Tailed phages use a broad range of receptor-binding proteins, such as tail fibres, tail spikes and the central tail spike, to target...

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Bibliographic Details
Published in:Nature reviews. Microbiology Vol. 16; no. 12; pp. 760 - 773
Main Authors: Nobrega, Franklin L, Vlot, Marnix, de Jonge, Patrick A, Dreesens, Lisa L, Beaumont, Hubertus J E, Lavigne, Rob, Dutilh, Bas E, Brouns, Stan J J
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.12.2018
Subjects:
Adsorption
Bacteria
Biotechnology
Cell surface
Fibers
Genomes
Gram-positive bacteria
Host range
Molecular modelling
Phages
Proteins
Receptor mechanisms
Receptors
Structure-function relationships
ISSN:1740-1526, 1740-1534, 1740-1534
Online Access:Get full text
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Summary:Phages differ substantially in the bacterial hosts that they infect. Their host range is determined by the specific structures that they use to target bacterial cells. Tailed phages use a broad range of receptor-binding proteins, such as tail fibres, tail spikes and the central tail spike, to target their cognate bacterial cell surface receptors. Recent technical advances and new structure-function insights have begun to unravel the molecular mechanisms and temporal dynamics that govern these interactions. Here, we review the current understanding of the targeting machinery and mechanisms of tailed phages. These new insights and approaches pave the way for the application of phages in medicine and biotechnology and enable deeper understanding of their ecology and evolution.
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ISSN:1740-1526
1740-1534
1740-1534
DOI:10.1038/s41579-018-0070-8