Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling

Lymph node fibroblastic reticular cells (FRCs) respond to signals from activated T cells by releasing nitric oxide, which inhibits T cell proliferation and restricts the size of the expanding T cell pool. Whether interactions with FRCs also support the function or differentiation of activated CD8 +...

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Bibliographic Details
Published in:	Nature immunology Vol. 20; no. 12; pp. 1668 - 1680
Main Authors:	Brown, Flavian D., Sen, Debattama R., LaFleur, Martin W., Godec, Jernej, Lukacs-Kornek, Veronika, Schildberg, Frank A., Kim, Hye-Jung, Yates, Kathleen B., Ricoult, Stéphane J. H., Bi, Kevin, Trombley, Justin D., Kapoor, Varun N., Stanley, Illana A., Cremasco, Viviana, Danial, Nika N., Manning, Brendan D., Sharpe, Arlene H., Haining, W. Nicholas, Turley, Shannon J.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.12.2019 Nature Publishing Group
Subjects:	631/1647 631/250 Animals Biomedical and Life Sciences Biomedicine CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell Differentiation Cell Proliferation Cell Survival Cells, Cultured Cellular Reprogramming Chromatin Chromatin Assembly and Disassembly Cytotoxicity, Immunologic Epigenesis, Genetic Epigenetic inheritance Epigenetics Fibroblasts - physiology Gene Expression Regulation Immunologic Memory Immunological memory Immunology Infectious Diseases Interleukin 6 Interleukin-6 - genetics Interleukin-6 - metabolism Interleukins Lymph nodes Lymph Nodes - immunology Lymphocyte Activation Lymphocytes Lymphocytes T Lymphoid tissue Memory cells Mice Mice, Inbred C57BL Mice, Knockout Nitric oxide Nitric Oxide - metabolism T cells Massachusetts
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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