Atopic disease and exhaled nitric oxide in an unselected population of young adults

Several studies have reported elevated levels of fractional exhaled nitric oxide (FeNO) in atopic patients, particularly in asthmatic patients, suggesting that FeNO is a marker of bronchial inflammation. However, the independent influence of different atopic entities (eczema, allergic rhinitis, and...

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Bibliographic Details
Published in:Annals of allergy, asthma, & immunology Vol. 100; no. 1; p. 59
Main Authors: van Asch, Charlotte J J, Balemans, Walter A F, Rovers, Maroeska M, Schilder, Anne G M, van der Ent, Cornelis K
Format: Journal Article
Language:English
Published: United States 01.01.2008
Subjects:
Adult
Antigens - immunology
Asthma - epidemiology
Asthma - metabolism
Biomarkers - analysis
Biomarkers - metabolism
Body Mass Index
Breath Tests
Dermatitis, Atopic - epidemiology
Dermatitis, Atopic - metabolism
Female
Forced Expiratory Volume - physiology
Humans
Immunoglobulin E - blood
Immunoglobulin E - immunology
Male
Netherlands - epidemiology
Nitric Oxide - analysis
Nitric Oxide - metabolism
Rhinitis, Allergic, Perennial - epidemiology
Rhinitis, Allergic, Perennial - metabolism
Rhinitis, Allergic, Seasonal - epidemiology
Rhinitis, Allergic, Seasonal - metabolism
Sex Characteristics
Smoking - epidemiology
Smoking - metabolism
Spirometry
Surveys and Questionnaires
Vital Capacity - physiology
Netherlands
ISSN:1081-1206
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Summary:Several studies have reported elevated levels of fractional exhaled nitric oxide (FeNO) in atopic patients, particularly in asthmatic patients, suggesting that FeNO is a marker of bronchial inflammation. However, the independent influence of different atopic entities (eczema, allergic rhinitis, and asthma) on FeNO has never been studied in the general population. To study the influence of a questionnaire-based diagnosis of atopic diseases and IgE and lung function measurements on FeNO levels. This study was part of a follow-up on otitis media of a birth cohort of 1,328 children born in Nijmegen, the Netherlands, between September 1, 1982, and August 31, 1983. Within the birth cohort, the incidence of asthma, allergic rhinitis, and eczema was determined, and off-line FeNO, spirometry, and IgE measurements were performed at the age of 21 years. FeNO measurements were successfully performed in 361 participants. Median FeNO levels were significantly higher in those with vs without eczema (23.6 vs 18.0 ppb; P < .0001), those with vs without allergic rhinitis (20.7 vs 17.8 ppb; P = .0001), and those with vs without atopic asthma (23.3 vs 18.1 ppb; P = .02) but not in those with vs without asthma (20.8 vs 18.3 ppb; P = .24). Eczema, allergic rhinitis, smoking, sex, and atopic sensitization appeared to be independently associated with log FeNO in this population sample, whereas (atopic) asthma was not. No effect on FeNO levels was observed for lung function parameters. Eczema, allergic rhinitis, and atopic status were all independently associated with elevated FeNO levels, whereas (atopic) asthma was not. This finding implies that future studies into the role of FeNO in asthma should consider the influence of atopic disease outside the lungs.
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ISSN:1081-1206
DOI:10.1016/S1081-1206(10)60406-1