Functional interactions among microRNAs and long noncoding RNAs

•LncRNA stability and function can be potently regulated by miRNAs.•LncRNAs can function as miRNA decoys, derepressing miRNA target mRNAs.•LncRNAs can compete with miRNAs for degradation of target mRNAs.•LncRNAs can give rise to miRNA. In mammals, the vast majority of transcripts expressed are nonco...

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Vydáno v:Seminars in cell & developmental biology Ročník 34; s. 9 - 14
Hlavní autoři: Yoon, Je-Hyun, Abdelmohsen, Kotb, Gorospe, Myriam
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.10.2014
Témata:
Animals
Humans
MicroRNAs - physiology
mRNA stability
Post-transcriptional gene regulation
Ribonucleoprotein complex
RNA Interference
RNA, Long Noncoding - physiology
RNA-binding protein
Translation
ceRNA
RBP
UTR
Ribonucleoprotein complex
RNA-binding protein
Translation
lncRNA
Post-transcriptional gene regulation
lincRNA
miRNA
mRNA stability
ISSN:1084-9521, 1096-3634, 1096-3634
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Shrnutí:•LncRNA stability and function can be potently regulated by miRNAs.•LncRNAs can function as miRNA decoys, derepressing miRNA target mRNAs.•LncRNAs can compete with miRNAs for degradation of target mRNAs.•LncRNAs can give rise to miRNA. In mammals, the vast majority of transcripts expressed are noncoding RNAs, ranging from short RNAs (including microRNAs) to long RNAs spanning up to hundreds of kb. While the actions of microRNAs as destabilizers and repressors of the translation of protein-coding transcripts (mRNAs) have been studied in detail, the influence of microRNAs on long noncoding RNA (lncRNA) function is only now coming into view. Conversely, the influence of lncRNAs upon microRNA function is also rapidly emerging. In some cases, lncRNA stability is reduced through the interaction of specific miRNAs. In other cases, lncRNAs can act as microRNA decoys, with the sequestration of microRNAs favoring expression of repressed target mRNAs. Other lncRNAs derepress gene expression by competing with miRNAs for interaction with shared target mRNAs. Finally, some lncRNAs can produce miRNAs, leading to repression of target mRNAs. These microRNA–lncRNA regulatory paradigms modulate gene expression patterns that drive major cellular processes (such as cell differentiation, proliferation, and cell death) which are central to mammalian physiologic and pathologic processes. We review and summarize the types of microRNA–lncRNA crosstalk identified to-date and discuss their influence on gene expression programs.
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ISSN:1084-9521
1096-3634
1096-3634
DOI:10.1016/j.semcdb.2014.05.015