CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Depleting regulatory T cells (T reg cells) to counteract immunosuppressive features of the tumor microenvironment (TME) is an attractive strategy for cancer treatment; however, autoimmunity due to systemic impairment of their suppressive function limits its therapeutic potential. Elucidating approac...

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Bibliographic Details
Published in:	Nature immunology Vol. 21; no. 3; pp. 298 - 308
Main Authors:	Wang, Haiping, Franco, Fabien, Tsui, Yao-Chen, Xie, Xin, Trefny, Marcel P., Zappasodi, Roberta, Mohmood, Syed Raza, Fernández-García, Juan, Tsai, Chin-Hsien, Schulze, Isabell, Picard, Florence, Meylan, Etienne, Silverstein, Roy, Goldberg, Ira, Fendt, Sarah-Maria, Wolchok, Jedd D., Merghoub, Taha, Jandus, Camilla, Zippelius, Alfred, Ho, Ping-Chih
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.03.2020 Nature Publishing Group
Subjects:	631/250/2152 631/67/580 Adaptation Animals Antitumor activity Apoptosis Apoptosis - immunology Autoimmunity Biomedical and Life Sciences Biomedicine Cancer immunotherapy CD36 antigen CD36 Antigens - deficiency CD36 Antigens - genetics CD36 Antigens - immunology Cell death Cell Line, Tumor Cell metabolism Cell survival Fatty acids Female Genetic aspects Genetic regulation Health aspects Homeostasis Homeostasis - immunology Humans Immunology Immunoregulation Immunotherapy Infectious Diseases Lactic acid Lipid Metabolism - genetics Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Male Metabolism Mice Mice, Inbred C57BL Mice, Knockout Mitochondria Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology PPAR-beta - immunology Signal Transduction - immunology T cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology Tumor microenvironment Tumor Microenvironment - immunology Tumor-infiltrating lymphocytes Tumors Switzerland
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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