DNA sensing by the cGAS-STING pathway in health and disease

The detection of pathogens through nucleic acid sensors is a defining principle of innate immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for foreign nucleic acids and, upon recognition, trigger immune signalling pathways for host defence. Over the past decade, our un...

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Bibliographic Details
Published in:	Nature reviews. Genetics Vol. 20; no. 11; pp. 657 - 674
Main Authors:	Motwani, Mona, Pesiridis, Scott, Fitzgerald, Katherine A
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.11.2019
Subjects:	AMP Animals Antagonists Cancer Cyclic GMP Deoxyribonucleic acid DNA DNA, Neoplasm - immunology Gene expression Humans Inflammation - immunology Inflammation - pathology Inflammatory diseases Innate immunity Interferon Mammalian cells Membrane Proteins - immunology Neoplasms - immunology Neoplasms - pathology Nucleic acids Nucleotidyltransferases - immunology Ribonucleic acid RNA Signal transduction Signal Transduction - immunology
ISSN:	1471-0056, 1471-0064, 1471-0064
Online Access:	Get full text
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