Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

David Ellison and colleagues report whole-genome sequencing of pediatric low-grade gliomas, the most common pediatric brain tumor. They identify a range of genomic alterations, including recurrent and mutually exclusive duplications of the FGFR1 region encoding the tyrosine kinase domain and rearran...

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Bibliographic Details
Published in:	Nature genetics Vol. 45; no. 6; pp. 602 - 612
Main Authors:	Zhang, Jinghui, Wu, Gang, Miller, Claudia P, Tatevossian, Ruth G, Dalton, James D, Tang, Bo, Orisme, Wilda, Punchihewa, Chandanamali, Parker, Matthew, Qaddoumi, Ibrahim, Boop, Fredrick A, Lu, Charles, Kandoth, Cyriac, Ding, Li, Lee, Ryan, Huether, Robert, Chen, Xiang, Hedlund, Erin, Nagahawatte, Panduka, Rusch, Michael, Boggs, Kristy, Cheng, Jinjun, Becksfort, Jared, Ma, Jing, Song, Guangchun, Li, Yongjin, Wei, Lei, Wang, Jianmin, Shurtleff, Sheila, Easton, John, Zhao, David, Fulton, Robert S, Fulton, Lucinda L, Dooling, David J, Vadodaria, Bhavin, Mulder, Heather L, Tang, Chunlao, Ochoa, Kerri, Mullighan, Charles G, Gajjar, Amar, Kriwacki, Richard, Sheer, Denise, Gilbertson, Richard J, Mardis, Elaine R, Wilson, Richard K, Downing, James R, Baker, Suzanne J, Ellison, David W
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.06.2013 Nature Publishing Group
Subjects:	692/308/2056 Adolescent Agriculture Animal Genetics and Genomics Animals Base Sequence Biomedicine Brain Neoplasms - genetics Brain Neoplasms - pathology Brain tumors Cancer Research Child Child, Preschool Children & youth Diagnosis DNA sequencing Female Gene Duplication Gene expression Gene Function Gene Rearrangement Genes, myb Genetic aspects Genome-Wide Association Study Genomes Glioma - genetics Glioma - pathology Gliomas Human Genetics Humans Infant Kinases Male Mice Mice, Nude Molecular Sequence Data Morbidity Mortality Mutation Neoplasm Grading Neoplasm Transplantation Nucleotide sequencing Pediatrics Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf Receptor, Fibroblast Growth Factor, Type 1 - genetics Risk factors Sequence Analysis, DNA Signal Transduction Trans-Activators - genetics Transcriptome Tumors United States
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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