miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors

Expression of BRCA1 is commonly decreased in sporadic breast tumors, and this correlates with poor prognosis of breast cancer patients. Here we show that BRCA1 transcripts are selectively enriched in the Argonaute/miR-182 complex and miR-182 downregulates BRCA1 expression. Antagonizing miR-182 enhan...

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Veröffentlicht in:	Molecular cell Jg. 41; H. 2; S. 210
Hauptverfasser:	Moskwa, Patryk, Buffa, Francesca M, Pan, Yunfeng, Panchakshari, Rohit, Gottipati, Ponnari, Muschel, Ruth J, Beech, John, Kulshrestha, Ritu, Abdelmohsen, Kotb, Weinstock, David M, Gorospe, Myriam, Harris, Adrian L, Helleday, Thomas, Chowdhury, Dipanjan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.01.2011
Schlagworte:	Animals Antineoplastic Agents - pharmacology BRCA1 Protein - genetics Cell Differentiation Cell Line, Tumor DNA Breaks, Double-Stranded - radiation effects DNA Repair - drug effects Down-Regulation Humans K562 Cells Mice MicroRNAs - genetics MicroRNAs - metabolism MicroRNAs - physiology Phthalazines - pharmacology Piperazines - pharmacology Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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