Iron in Chronic Brain Disorders: Imaging and Neurotherapeutic Implications

Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer’s disease, Parkin...

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Vydáno v:	Neurotherapeutics Ročník 4; číslo 3; s. 371 - 386
Hlavní autoři:	Stankiewicz, James, Panter, S. Scott, Neema, Mohit, Arora, Ashish, Batt, Courtney E., Bakshi, Rohit
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 01.07.2007 Springer Nature B.V Springer-Verlag
Témata:	Alzheimer’s disease Animals Brain - metabolism Brain - pathology chelation Free radicals Humans Iron Iron - metabolism Iron Metabolism Disorders - pathology Magnetic Resonance Imaging MRI multiple sclerosis neurodegeneration Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Parkinson’s disease Alzheimer’s disease MRI chelation multiple sclerosis neurodegeneration Iron Parkinson’s disease
ISSN:	1878-7479, 1933-7213, 1878-7479
On-line přístup:	Získat plný text
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Shrnutí:	Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. In vitro studies have demonstrated that excessive iron can lead to free radical production, which can promote neurotoxicity. However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood. It is not known whether excessive in vivo iron directly contributes to tissue damage or is solely an epiphenomenon. In this article, we focus on the imaging of brain iron and the underlying physiology and metabolism relating to iron deposition. We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1878-7479 1933-7213 1878-7479
DOI:	10.1016/j.nurt.2007.05.006