Iron in Chronic Brain Disorders: Imaging and Neurotherapeutic Implications

Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer’s disease, Parkin...

Full description

Saved in:
Bibliographic Details
Published in:Neurotherapeutics Vol. 4; no. 3; pp. 371 - 386
Main Authors: Stankiewicz, James, Panter, S. Scott, Neema, Mohit, Arora, Ashish, Batt, Courtney E., Bakshi, Rohit
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.07.2007
Springer Nature B.V
Springer-Verlag
Subjects:
Alzheimer’s disease
Animals
Brain - metabolism
Brain - pathology
chelation
Free radicals
Humans
Iron
Iron - metabolism
Iron Metabolism Disorders - pathology
Magnetic Resonance Imaging
MRI
multiple sclerosis
neurodegeneration
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
Parkinson’s disease
Alzheimer’s disease
MRI
chelation
multiple sclerosis
neurodegeneration
Iron
Parkinson’s disease
ISSN:1878-7479, 1933-7213, 1878-7479
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. In vitro studies have demonstrated that excessive iron can lead to free radical production, which can promote neurotoxicity. However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood. It is not known whether excessive in vivo iron directly contributes to tissue damage or is solely an epiphenomenon. In this article, we focus on the imaging of brain iron and the underlying physiology and metabolism relating to iron deposition. We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development.
AbstractList Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. In vitro studies have demonstrated that excessive iron can lead to free radical production, which can promote neurotoxicity. However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood. It is not known whether excessive in vivo iron directly contributes to tissue damage or is solely an epiphenomenon. In this article, we focus on the imaging of brain iron and the underlying physiology and metabolism relating to iron deposition. We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development.
Issue Title: Advances in Neuroimaging/Neuroethics Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In vitro studies have demonstrated that excessive iron can lead to free radical production, which can promote neurotoxicity. However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood. It is not known whether excessive in vivo iron directly contributes to tissue damage or is solely an epiphenomenon. In this article, we focus on the imaging of brain iron and the underlying physiology and metabolism relating to iron deposition. We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development.[PUBLICATION ABSTRACT]
Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. In vitro studies have demonstrated that excessive iron can lead to free radical production, which can promote neurotoxicity. However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood. It is not known whether excessive in vivo iron directly contributes to tissue damage or is solely an epiphenomenon. In this article, we focus on the imaging of brain iron and the underlying physiology and metabolism relating to iron deposition. We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development.
Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In vitro studies have demonstrated that excessive iron can lead to free radical production, which can promote neurotoxicity. However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood. It is not known whether excessive in vivo iron directly contributes to tissue damage or is solely an epiphenomenon. In this article, we focus on the imaging of brain iron and the underlying physiology and metabolism relating to iron deposition. We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development.Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In vitro studies have demonstrated that excessive iron can lead to free radical production, which can promote neurotoxicity. However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood. It is not known whether excessive in vivo iron directly contributes to tissue damage or is solely an epiphenomenon. In this article, we focus on the imaging of brain iron and the underlying physiology and metabolism relating to iron deposition. We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development.
Author Panter, S. Scott
Neema, Mohit
Bakshi, Rohit
Batt, Courtney E.
Stankiewicz, James
Arora, Ashish
Author_xml – sequence: 1
  givenname: James
  surname: Stankiewicz
  fullname: Stankiewicz, James
  organization: Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115
– sequence: 2
  givenname: S. Scott
  surname: Panter
  fullname: Panter, S. Scott
  organization: Department of Neurological Surgery, Veteran’s Administration Hospital, University of California, San Francisco, California 94121
– sequence: 3
  givenname: Mohit
  surname: Neema
  fullname: Neema, Mohit
  organization: Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115
– sequence: 4
  givenname: Ashish
  surname: Arora
  fullname: Arora, Ashish
  organization: Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115
– sequence: 5
  givenname: Courtney E.
  surname: Batt
  fullname: Batt, Courtney E.
  organization: Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115
– sequence: 6
  givenname: Rohit
  surname: Bakshi
  fullname: Bakshi, Rohit
  email: rbakshi@bwh.harvard.edu
  organization: Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115
BackLink https://www.ncbi.nlm.nih.gov/pubmed/17599703$$D View this record in MEDLINE/PubMed
BookMark eNqFkstuEzEUhi3Uil7gBVigkZDYZTj2xPZMhZAgBRpUwQbWlmOfSRxm7NSeqdS3r0MKtFm0Kx_L_3duv0_IgQ8eCXlFoaRAxbt16cc4lAxAlsBLAPGMHNNa1hM5lc3BvfiInKS0BuBV1dTPyRGVvGkkVMfk2zwGXzhfzFY5cKb4FHW-nbsUosWYzop5r5fOLwvtbfEdxxiGFUa9wXHI6nm_6ZzRgws-vSCHre4Svrw7T8mvL59_zi4mlz--zmcfLyeGN_Uw0dW00lIbtkBR15URvFpAu2g05VYIK1otqGEMjZ3WHDiwVlgmuZUUjDR5hFPyYZd3My56tAb9EHWnNtH1Ot6ooJ16-OLdSi3DtaKNqKZU5gRv7xLEcDViGlTvksGu0x7DmJQEwVlDt5Xe7AnXYYw-D6copYxxIRhk1ev7_fxr5O-Ss4DtBCaGlCK2_yWgtk6qtdo6qbZOKuAqO5mheg8ybviz6DyT6x5H3-9QzC5cO4wqGYfeoHURzaBscI_jZ3u46Vz-Grr7jTdPwbcln83A
CitedBy_id crossref_primary_10_1111_j_1471_4159_2010_06607_x
crossref_primary_10_1111_epi_12593
crossref_primary_10_1111_j_1552_6569_2008_00349_x
crossref_primary_10_1002_jmri_22185
crossref_primary_10_1002_jmri_24121
crossref_primary_10_1016_j_mri_2019_05_022
crossref_primary_10_1007_s10534_012_9545_7
crossref_primary_10_1111_j_1471_4159_2010_07132_x
crossref_primary_10_1016_j_nicl_2021_102786
crossref_primary_10_1148_radiol_10100495
crossref_primary_10_17816_MAJ11112_29
crossref_primary_10_1002_mrm_23054
crossref_primary_10_1016_j_clinimag_2013_02_001
crossref_primary_10_3390_biom5042675
crossref_primary_10_1002_mrm_25114
crossref_primary_10_3390_ijms21238951
crossref_primary_10_1016_j_crad_2015_01_005
crossref_primary_10_1016_j_autrev_2025_103741
crossref_primary_10_1212_WNL_0000000000001679
crossref_primary_10_1042_BST20140106
crossref_primary_10_1111_j_1753_4887_2012_00521_x
crossref_primary_10_1177_1352458515614091
crossref_primary_10_3389_fnagi_2015_00206
crossref_primary_10_1002_mrm_26791
crossref_primary_10_1007_s00441_011_1152_3
crossref_primary_10_1002_nbm_4565
crossref_primary_10_1155_2018_6709525
crossref_primary_10_1007_s11011_014_9608_2
crossref_primary_10_2478_v10163_012_0026_4
crossref_primary_10_1002_jmri_22293
crossref_primary_10_1155_2011_606807
crossref_primary_10_3389_fnins_2024_1263724
crossref_primary_10_1002_jmri_22884
crossref_primary_10_1016_j_neurobiolaging_2009_08_007
crossref_primary_10_1371_journal_pone_0193867
crossref_primary_10_1016_j_ccr_2012_03_013
crossref_primary_10_1016_j_jns_2015_05_027
crossref_primary_10_1111_jon_12775
crossref_primary_10_1097_SCS_0000000000005597
crossref_primary_10_1016_j_nicl_2022_103021
crossref_primary_10_1007_s40120_016_0054_4
crossref_primary_10_3389_fnhum_2017_00442
crossref_primary_10_1016_j_neuroscience_2017_07_055
crossref_primary_10_1016_j_crad_2024_01_007
crossref_primary_10_1007_s00234_009_0497_8
crossref_primary_10_3390_jcm11216414
crossref_primary_10_1016_j_neuroimage_2021_118012
crossref_primary_10_1111_jnc_12739
crossref_primary_10_1177_1352458512465135
crossref_primary_10_1177_0192623317734847
crossref_primary_10_1016_j_freeradbiomed_2020_11_019
crossref_primary_10_1002_jmri_23603
crossref_primary_10_1016_j_nbd_2023_106252
crossref_primary_10_1016_j_jns_2010_07_014
crossref_primary_10_3389_fneur_2021_785822
crossref_primary_10_1002_mds_26306
crossref_primary_10_1016_j_neuroimage_2011_11_081
crossref_primary_10_3109_02713683_2013_833244
crossref_primary_10_1177_1352458510395645
crossref_primary_10_1002_jmri_26226
crossref_primary_10_1016_j_jns_2016_12_039
crossref_primary_10_1177_1352458512447870
crossref_primary_10_1177_20552173211010832
crossref_primary_10_1007_s13738_021_02181_4
crossref_primary_10_1074_jbc_M114_606731
crossref_primary_10_1097_MCO_0b013e32831fd97a
crossref_primary_10_1002_jmri_25130
crossref_primary_10_1155_2012_197438
crossref_primary_10_1177_1352458514530020
crossref_primary_10_1134_S1819712414030040
crossref_primary_10_1016_j_ejro_2019_04_005
crossref_primary_10_1186_1755_8794_2_2
crossref_primary_10_1016_j_mri_2016_12_025
crossref_primary_10_1083_jcb_201602069
crossref_primary_10_1007_s00062_011_0127_9
crossref_primary_10_1038_s41598_020_72630_2
crossref_primary_10_1016_j_nicl_2017_01_029
crossref_primary_10_1002_mds_23971
crossref_primary_10_1186_1471_2350_13_70
crossref_primary_10_1155_2020_1245875
crossref_primary_10_1371_journal_pone_0112941
crossref_primary_10_1016_j_jtemb_2013_09_006
crossref_primary_10_1097_MD_0000000000003594
crossref_primary_10_1155_2020_5471987
crossref_primary_10_1177_1352458509106609
crossref_primary_10_1016_j_bbrc_2008_07_061
crossref_primary_10_1016_j_spen_2012_03_007
crossref_primary_10_1080_00207454_2017_1283313
crossref_primary_10_1016_j_neuroimage_2010_03_048
crossref_primary_10_1016_j_spen_2012_03_004
crossref_primary_10_1016_j_spen_2012_03_005
crossref_primary_10_1007_s00431_025_06287_2
crossref_primary_10_1016_j_bbadis_2011_06_016
crossref_primary_10_1212_WNL_0000000000209747
crossref_primary_10_1002_mds_25263
crossref_primary_10_1016_j_neuint_2012_04_018
crossref_primary_10_2217_14796708_3_4_447
crossref_primary_10_3390_healthcare10091681
crossref_primary_10_3390_nu10111707
crossref_primary_10_1002_mrm_26371
crossref_primary_10_1155_2013_726954
crossref_primary_10_1002_mds_23751
crossref_primary_10_3389_fneur_2020_623914
crossref_primary_10_1002_nbm_2847
crossref_primary_10_1111_nan_12493
crossref_primary_10_1007_s12011_012_9564_9
crossref_primary_10_1007_s11940_013_0254_5
crossref_primary_10_1016_j_neubiorev_2024_105788
crossref_primary_10_1016_j_mri_2023_01_021
crossref_primary_10_1161_CIRCRESAHA_116_309746
crossref_primary_10_3390_ijms17010100
crossref_primary_10_1039_c2mt20052j
crossref_primary_10_1093_cercor_bhaf059
crossref_primary_10_1002_jmri_22452
crossref_primary_10_1016_j_nurt_2007_05_004
crossref_primary_10_1016_j_nicl_2017_05_009
crossref_primary_10_1371_journal_pone_0196297
crossref_primary_10_1111_j_1552_6569_2008_00296_x
crossref_primary_10_1007_s00018_014_1570_y
crossref_primary_10_1016_j_neuroimage_2010_03_056
crossref_primary_10_1093_schbul_sbad041
crossref_primary_10_1016_j_neuroscience_2017_08_023
crossref_primary_10_3389_fnins_2017_00657
crossref_primary_10_3389_fnins_2022_918623
crossref_primary_10_1089_ars_2012_5068
crossref_primary_10_1002_jmri_23578
crossref_primary_10_1007_s12311_010_0189_2
crossref_primary_10_1038_s41598_019_48087_3
crossref_primary_10_1016_j_neuint_2012_11_015
crossref_primary_10_1002_tox_23543
crossref_primary_10_1007_s11065_015_9292_y
crossref_primary_10_1038_s41598_020_69979_9
crossref_primary_10_3389_fnhum_2021_654381
crossref_primary_10_1016_j_acra_2020_10_027
crossref_primary_10_1016_j_neuroimage_2010_11_073
crossref_primary_10_1038_s41419_018_0379_2
crossref_primary_10_1016_j_neuroimage_2020_117285
crossref_primary_10_1148_radiol_2020200378
crossref_primary_10_1212_WNL_0000000000000840
crossref_primary_10_1002_ana_21582
crossref_primary_10_1002_ar_20995
crossref_primary_10_1016_j_bbadis_2020_165663
crossref_primary_10_1016_j_neurobiolaging_2014_03_039
crossref_primary_10_1097_WCO_0b013e328354f63f
crossref_primary_10_3389_fnins_2018_00981
crossref_primary_10_1002_jmri_22590
crossref_primary_10_1186_s41747_022_00279_9
crossref_primary_10_1002_hbm_23054
crossref_primary_10_1016_j_jtemb_2024_127527
crossref_primary_10_1093_braincomms_fcaf110
crossref_primary_10_1016_j_neuroimage_2022_119683
crossref_primary_10_1177_1352458509103713
crossref_primary_10_1038_s41598_017_05117_2
crossref_primary_10_1016_j_nurt_2007_08_001
crossref_primary_10_3389_fneur_2024_1518911
crossref_primary_10_1016_j_trsl_2016_03_005
crossref_primary_10_1148_radiol_2017170744
crossref_primary_10_1007_s12011_010_8841_8
crossref_primary_10_1007_s12035_023_03696_y
crossref_primary_10_1007_s11011_019_00515_z
crossref_primary_10_1186_s41983_023_00732_5
crossref_primary_10_1212_WNL_0000000000008893
crossref_primary_10_1111_jon_12364
crossref_primary_10_1586_ern_11_117
crossref_primary_10_3390_antiox9101020
crossref_primary_10_1080_10807030802494667
crossref_primary_10_1148_radiol_11101362
crossref_primary_10_1177_1352458509350310
crossref_primary_10_1097_MCO_0b013e32831ba07c
crossref_primary_10_1118_1_4908203
crossref_primary_10_1111_j_1471_4159_2009_06470_x
crossref_primary_10_1177_1352458509103611
crossref_primary_10_1016_j_jns_2012_11_009
crossref_primary_10_1016_j_rcl_2013_11_011
crossref_primary_10_1016_j_nicl_2016_12_025
crossref_primary_10_1016_j_neuroimage_2011_03_046
crossref_primary_10_1111_cns_70018
crossref_primary_10_17116_jnevro201811808210
crossref_primary_10_1186_s12868_014_0117_3
crossref_primary_10_1186_s12916_023_02855_1
crossref_primary_10_1134_S1819712417020052
crossref_primary_10_1002_ana_21640
crossref_primary_10_1097_RCT_0b013e3181cbf73c
crossref_primary_10_1016_S1474_4422_11_70105_3
crossref_primary_10_1109_TIM_2018_2791218
crossref_primary_10_1148_radiol_09091136
crossref_primary_10_1186_1471_2202_12_60
crossref_primary_10_3109_15622975_2011_570376
crossref_primary_10_1016_j_nicl_2021_102736
crossref_primary_10_1007_s00204_010_0577_x
crossref_primary_10_1371_journal_pone_0031748
crossref_primary_10_1016_j_neuroimage_2011_07_045
crossref_primary_10_1212_WNL_0b013e318236ef0e
crossref_primary_10_1088_0953_8984_24_24_244104
crossref_primary_10_1016_S1474_4422_08_70137_6
crossref_primary_10_1111_febs_15570
crossref_primary_10_1016_j_nic_2012_02_010
crossref_primary_10_1111_j_1471_4159_2008_05570_x
Cites_doi 10.1038/nrn1537
10.1016/0165-5728(94)00154-G
10.1016/0006-3223(94)90047-7
10.1007/s002340050002
10.1212/WNL.43.4.697
10.1016/S0165-5728(02)00269-2
10.1002/mrm.21118
10.1111/j.1471-4159.1989.tb09150.x
10.1016/S1474-4422(03)00353-3
10.1002/mds.870110104
10.1196/annals.1306.024
10.1002/ana.410340505
10.2337/diacare.25.12.2249
10.1196/annals.1306.007
10.1097/01.rmr.0000245459.82782.e4
10.1016/S0891-5849(99)00262-2
10.1016/0006-8993(95)01500-0
10.1002/jnr.20957
10.1196/annals.1306.026
10.1007/s100720300036
10.1001/archneur.62.9.1371
10.1002/(SICI)1098-1136(199606)17:2<83::AID-GLIA1>3.0.CO;2-7
10.1084/jem.160.5.1532
10.1002/mrm.1910370107
10.1038/91036
10.1007/s00415-005-0914-9
10.1016/S0024-3205(98)00512-8
10.1016/0165-5728(88)90020-3
10.1136/jnnp.59.3.318
10.1016/0165-5728(95)00104-A
10.1002/(SICI)1097-4547(19981115)54:4<486::AID-JNR6>3.0.CO;2-I
10.1002/ana.410320616
10.1148/radiology.211.2.r99ma53489
10.1016/j.mri.2004.10.001
10.1212/WNL.45.6.1138
10.1016/j.brainresrev.2005.03.003
10.1111/j.1471-4159.1958.tb12607.x
10.1001/archneur.60.12.1685
10.1002/0470868694.ch3
10.1097/00001756-200001170-00004
10.1042/bj2880591
10.1073/pnas.0403495101
10.1196/annals.1306.019
10.1001/archneur.62.4.621
10.1016/j.neulet.2006.07.020
10.1148/radiology.193.2.7972765
10.1002/jmri.20244
10.1002/mds.21227
10.1046/j.1471-4159.2001.00354.x
10.1111/j.1749-6632.2000.tb06180.x
10.1016/S0162-0134(02)00461-0
10.1016/S0006-8993(97)00470-8
10.1523/JNEUROSCI.21-12-04183.2001
10.1016/j.neurobiolaging.2004.01.005
10.1089/neu.1992.9.47
10.1097/00001756-199801260-00001
10.1136/jnnp.61.5.506
10.1161/01.STR.27.9.1453
10.1042/bj2870509
10.1016/j.braindev.2007.01.001
10.1016/j.jns.2005.02.009
10.1016/0891-5849(92)90055-L
10.1038/ng572
10.1002/mrm.20284
10.1017/S0317167100029140
10.1148/radiology.210.3.r99fe41759
10.1002/mrm.1910370611
10.1002/mds.20550
10.1002/ajmg.b.10069
10.1196/annals.1306.008
10.1073/pnas.96.19.10812
10.1002/jnr.490270421
10.1212/01.WNL.0000068549.52812.0F
10.1056/NEJMoa050151
10.1038/ng571
10.1016/j.neurobiolaging.2006.02.005
10.1002/ana.410320724
10.1016/0140-6736(91)92978-B
10.1002/jmri.1880070203
10.1016/S0730-725X(96)00234-2
10.1046/j.1471-4159.2001.00490.x
10.1016/S0197-4580(00)83347-3
10.1093/jnen/64.4.280
10.1016/S0022-510X(02)00431-8
10.1038/sj.bjp.0706416
10.1191/135248506ms1301oa
10.1002/jnr.490370405
10.1016/S0006-2952(00)00399-3
10.1002/1531-8249(199907)46:1<123::AID-ANA19>3.0.CO;2-H
10.1016/S0140-6736(87)91361-4
10.1016/j.neures.2004.09.006
10.1093/hmg/11.21.2635
10.1177/1352458507076411
10.1016/j.pneurobio.2006.11.009
10.1002/mrm.1910350108
10.1016/0022-510X(95)00203-E
10.1006/exnr.1998.6968
10.1093/brain/123.12.2423
10.1002/jnr.490310214
10.2165/00002018-200022040-00002
10.1038/ncpneuro0356
10.1016/j.freeradbiomed.2005.05.021
10.1111/j.1471-4159.2005.03341.x
10.1161/str.29.6.1256/a
10.1097/00008480-200312000-00005
10.1111/j.1471-4159.1993.tb03639.x
10.1111/j.1471-4159.1990.tb08814.x
10.1111/j.1471-4159.1991.tb11444.x
10.1259/bjr.74.881.740407
10.1007/BF01277665
10.1002/ana.410410318
10.3171/jns.1998.89.4.0519
10.4067/S0716-97602006000100012
10.1016/S0006-8993(02)03893-3
10.1136/jnnp.73.1.91
10.1056/NEJM199704243361704
10.2214/ajr.149.2.357
10.1111/j.1600-0404.1991.tb05013.x
10.1001/jama.297.8.842
10.1002/mrm.20907
10.1002/mrm.1910320309
10.1097/00003246-200005000-00029
10.1016/S0891-5849(00)00494-9
10.1191/1352458503ms928oa
10.1001/archneur.1992.00530310053012
10.1046/j.1471-4159.1995.65020710.x
10.1196/annals.1306.015
10.1016/0090-3019(92)90087-4
10.1148/radiology.168.1.3380958
10.1016/j.neurobiolaging.2005.12.010
10.1111/jon199664222
10.1148/radiology.181.3.1947087
10.1002/mds.21020
10.1212/WNL.56.9.1200
10.1301/nr.2003.sept.311-313
10.1172/JCI118104
10.1111/j.1600-0404.1989.tb01782.x
10.1002/mds.870080102
10.1161/01.CIR.103.23.2799
10.1001/archpsyc.57.1.47
10.1196/annals.1306.022
10.2214/ajr.147.1.103
10.1016/S0165-5728(97)00256-7
10.1001/archneur.59.1.62
10.4049/jimmunol.173.9.5794
10.1016/j.neuropharm.2003.09.005
10.1007/s00702-006-0453-2
10.1039/CT8946500899
10.1016/j.mri.2006.09.008
10.1007/s002340050637
10.1002/ana.410320705
10.1016/S0730-725X(98)00155-6
10.1016/S0896-6273(03)00126-0
10.1093/brain/awl319
10.1007/s001250051669
10.1148/radiology.173.2.2798884
10.1016/S0896-6273(01)00317-8
10.1016/S0168-8278(02)00042-9
10.1016/0165-5728(94)90212-7
10.1002/mrm.1910290406
10.1111/j.1365-2249.2004.02344.x
10.1006/cimm.1997.1091
ContentType Journal Article
Copyright 2007 The American Society for Experimental NeuroTherapeutics, Inc.
Springer New York 2007
Copyright_xml – notice: 2007 The American Society for Experimental NeuroTherapeutics, Inc.
– notice: Springer New York 2007
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7RV
7TK
7X7
7XB
88E
88G
8AO
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
K9.
KB0
M0S
M1P
M2M
NAPCQ
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
PSYQQ
Q9U
7X8
5PM
DOI 10.1016/j.nurt.2007.05.006
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Nursing & Allied Health Database
Neurosciences Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Psychology Database (Alumni)
ProQuest Pharma Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni Edition)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
Health & Medical Collection (Alumni Edition)
Medical Database
Psychology Database
Nursing & Allied Health Premium
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest One Psychology
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest One Psychology
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Pharma Collection
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Psychology Journals (Alumni)
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest Psychology Journals
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
ProQuest One Psychology

MEDLINE

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7RV
  name: Nursing & Allied Health Database
  url: https://search.proquest.com/nahs
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1878-7479
EndPage 386
ExternalDocumentID PMC1963417
2789843901
17599703
10_1016_j_nurt_2007_05_006
S1933721307000906
S1878747923006487
Genre Review
Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NINDS NIH HHS
  grantid: 1 K23 NS42379-01
– fundername: NINDS NIH HHS
  grantid: K23 NS042379
GroupedDBID ---
--K
.1-
.FO
06D
0R~
0VY
123
1B1
203
29~
2JY
2KG
2KM
2VQ
30V
4.4
406
408
40E
53G
5VS
67N
71M
7RV
7X7
88E
8AO
8FI
8FJ
8UJ
96X
AAAVM
AABHQ
AAEDT
AAFWJ
AAHNG
AAIAL
AAJBT
AAJKR
AAKDD
AALRI
AANXM
AANZL
AAQFI
AARHV
AARTL
AATVU
AAUYE
AAWCG
AAXUO
AAYIU
AAYQN
AAYTO
AAYWO
AAZMS
ABDZT
ABECU
ABFSG
ABFTV
ABIPD
ABIVO
ABJOX
ABKCH
ABMQK
ABPLI
ABQBU
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABUWG
ABWVN
ABXPI
ACGFS
ACHSB
ACKNC
ACMDZ
ACMLO
ACOKC
ACPRK
ACRPL
ACSTC
ACVFH
ADBBV
ADCNI
ADHIR
ADJJI
ADKNI
ADKPE
ADMUD
ADNMO
ADRFC
ADTPH
ADURQ
ADVLN
ADYFF
ADZKW
AEBTG
AEGNC
AEJHL
AEJRE
AEKER
AENEX
AEOHA
AEPYU
AESKC
AETCA
AEUPX
AEVLU
AEXYK
AEZWR
AFBBN
AFHIU
AFJKZ
AFKRA
AFLOW
AFPKN
AFPUW
AFQWF
AFRHN
AFWTZ
AFZKB
AGAYW
AGDGC
AGJBK
AGMZJ
AGQEE
AGQMX
AGRTI
AGWZB
AGYKE
AHAVH
AHBYD
AHIZS
AHKAY
AHMBA
AHPBZ
AHSBF
AHWEU
AHYZX
AIAKS
AIGII
AIIXL
AILAN
AITGF
AITUG
AIXLP
AJBLW
AJRNO
AJUYK
AJZVZ
AKBMS
AKMHD
AKRWK
AKYEP
ALFXC
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMRAJ
AMXSW
AMYLF
ANMIH
AOCGG
AOIJS
APXCP
ASPBG
ATHPR
AVWKF
AXYYD
AYFIA
AZFZN
AZQEC
BENPR
BGNMA
BKEYQ
BMSDO
BPHCQ
BVXVI
CCPQU
CS3
CSCUP
DDRTE
DNIVK
DPUIP
DU5
DWQXO
DX2
EBLON
EBS
EIOEI
EJD
EN4
EO8
EO9
EP2
EP3
ESBYG
EX3
F5P
FDB
FEDTE
FERAY
FFXSO
FINBP
FNLPD
FNPLU
FRRFC
FSGXE
FYUFA
GGCAI
GGRSB
GJIRD
GNUQQ
GNWQR
GQ7
GROUPED_DOAJ
H13
HF~
HMCUK
HMJXF
HRMNR
HVGLF
HYE
HZ~
I0C
IHE
IKXTQ
IMOTQ
ITM
IWAJR
J-C
JBSCW
JZLTJ
KOV
LLZTM
M1P
M2M
M41
M4Y
MO0
NAPCQ
NPVJJ
NQ-
NQJWS
NU0
O9-
O93
O9I
O9J
OK1
OZT
PHGZM
PHGZT
PJZUB
PPXIY
PQQKQ
PROAC
PSQYO
PSYQQ
R9I
RLLFE
ROL
RPM
RPZ
RSV
S1Z
S27
S3A
S3B
SBL
SDG
SHX
SISQX
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
T13
TSG
U2A
U9L
UG4
UKHRP
UOJIU
UTJUX
UZXMN
VFIZW
W48
WK8
WOW
Z5R
ZMTXR
ZOVNA
~A9
~HD
-56
-5G
-BR
-EM
-~C
04C
2JN
3V.
AAFGU
AATNV
AAYFA
ABFGW
ABJNI
ABKAS
ABULA
ACBMV
ACBRV
ACBYP
ACIGE
ACIPQ
ACTTH
ACVWB
ACWMK
ACZOJ
ADINQ
ADMDM
ADOXG
AEFTE
AESTI
AEVTX
AFNRJ
AGGBP
AIMYW
AJDOV
AKQUC
EBD
EIHBH
EMOBN
GQ6
PT4
RIG
SV3
Z7U
Z7W
Z81
Z82
Z83
Z87
9DU
AAYXX
AFFHD
CITATION
AAYZH
AFCTW
ALIPV
CGR
CUY
CVF
ECM
EIF
NPM
7TK
7XB
8FK
K9.
PKEHL
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c598t-a343a7ac2be6883c653b0fb9a15d66d6fa61c22ecd4850502f6d275d710c7c053
IEDL.DBID BENPR
ISICitedReferencesCount 241
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000249762800006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1878-7479
1933-7213
IngestDate Tue Nov 04 02:03:05 EST 2025
Sun Nov 09 11:50:29 EST 2025
Sat Nov 01 17:16:31 EDT 2025
Mon Jul 21 05:51:50 EDT 2025
Tue Nov 18 21:39:45 EST 2025
Sat Nov 29 06:54:59 EST 2025
Fri Feb 23 02:19:56 EST 2024
Tue Oct 14 19:40:57 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords Alzheimer’s disease
MRI
chelation
multiple sclerosis
neurodegeneration
Iron
Parkinson’s disease
Language English
License http://www.elsevier.com/open-access/userlicense/1.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c598t-a343a7ac2be6883c653b0fb9a15d66d6fa61c22ecd4850502f6d275d710c7c053
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
OpenAccessLink https://www.clinicalkey.com/#!/content/1-s2.0-S1878747923006487
PMID 17599703
PQID 1112256620
PQPubID 1476362
PageCount 16
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_1963417
proquest_miscellaneous_70652915
proquest_journals_1112256620
pubmed_primary_17599703
crossref_primary_10_1016_j_nurt_2007_05_006
crossref_citationtrail_10_1016_j_nurt_2007_05_006
elsevier_sciencedirect_doi_10_1016_j_nurt_2007_05_006
elsevier_clinicalkey_doi_10_1016_j_nurt_2007_05_006
PublicationCentury 2000
PublicationDate 2007-07-01
PublicationDateYYYYMMDD 2007-07-01
PublicationDate_xml – month: 07
  year: 2007
  text: 2007-07-01
  day: 01
PublicationDecade 2000
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: New York
PublicationTitle Neurotherapeutics
PublicationTitleAlternate Neurotherapeutics
PublicationYear 2007
Publisher Elsevier Inc
Springer Nature B.V
Springer-Verlag
Publisher_xml – name: Elsevier Inc
– name: Springer Nature B.V
– name: Springer-Verlag
References Bartzokis, Tishler, Lu (bib80) 2007; 28
Fahn, Cohen (bib168) 1992; 32
Ritchie, Bush, Mackinnon (bib23) 2003; 60
Gelman, Gorell, Barker (bib33) 1999; 210
Lee, Friedman, Angel, Kozak, Koh (bib177) 2004; 25
Moos (bib70) 2002; 49
House, St Pierre, Kowdley (bib11) 2007; 57
Youdim, Ben-Shachar, Riederer (bib10) 1993; 8
Feng, LeBlanc, LeBlanc (bib149) 2000; 28
Levites, Weinreb, Maor, Youdim, Mandel (bib167) 2001; 78
Ehmann, Markesbery, Alauddin, Hossain, Brubaker (bib16) 1986; 7
Fenton (bib64) 1894; 65
Miyajima, Takahaski, Kamata (bib135) 1997; 41
Bjelakovic, Nikolova, Gluud, Simonetti, Gluud (bib176) 2007; 297
Duby, Foury, Ramazzotti, Herrmann, Lutz (bib124) 2002; 11
Haley (bib153) 1998; 29
Cornett, Markesbery, Ehmann (bib14) 1998; 19
Andersen (bib96) 2001; 235
Jenner (bib7) 1991; 136
Craelius, Migdal, Lussenhop (bib20) 1982; 106
Floris, Meddad, Padiglia, Musci (bib54) 2000; 60
Kamran, Bakshi (bib141) 1998; 40
Liu, Men, Harris (bib182) 2006; 406
Drayer, Burger, Darwin (bib75) 1986; 147
Waldvogel, van Gelderen, Hallet (bib125) 1999; 46
Van Landeghem, Sikstrom, Beckman, Adolfsson, Beckman (bib86) 1998; 9
Ponka (bib52) 2004; 1012
Pantopoulos (bib55) 2004
Fernandez-Real, Penarroja, Castro, Garcia-Bragado, Lopez-Bermejo, Ricart (bib161) 2002; 25
Hayflick (bib129) 2003; 15
Panter, Baughler, Hall (bib156) 1992; 9
Reichenbach, Venkatesan, Yablonskiy (bib44) 1997; 7
Dietrich, Bradley (bib147) 1988; 168
Wills, Sawle, Guilbert, Curtis (bib3) 2002; 73
Connor, Menzies (bib53) 1996; 17
Gorell, Ordidge, Brown (bib41) 1995; 45
Wheaton, Borthakur, Corbo (bib49) 2004; 52
Hansen, Willenborg, Cowden (bib172) 1995; 62
Chinnery, Crompton, Birchall (bib123) 2007; 130
Zhang, Zabad, Wei, Metz, Hill, Mitchell (bib116) 2007
Pulliam, Jennings, Kryscio (bib87) 2003; 119
Gerlach, Double, Youdim, Riederer (bib101) 2006; 70
Zucca, Bellei, Giannelli (bib72) 2006; 113
Nielsen, Neerup Jensen, Krabbe (bib142) 1995; 59
Rouault (bib74) 2001; 28
Bakshi, Benedict, Bermel (bib19) 2002; 59
Jenner, Olanow (bib8) 1996; 47
House, St Pierre, Foster (bib90) 2006; 27
Cass, Grondin, Andersen (bib81) 2007; 28
Bermel, Puli, Rudick (bib115) 2005; 62
Hall (bib148) 1992; 32
Shoham, Youdim (bib102) 2004; 1012
Haacke, Cheng, House (bib27) 2005; 23
Cameron, Cotter (bib160) 2001; 44
Bishop, Robinson (bib85) 2000; 21
Kosta, Argyropoulou, Markoula (bib100) 2006; 253
Petersen, Thomas, Grundman (bib165) 2005; 352
Atasoy, Nuyan, Tunc (bib99) 2004; 52
Crapper McLachlan, Dalton, Kruck (bib24) 1991; 337
Brass, Chen, Mulkern, Bakshi (bib22) 2006; 17
Richardson (bib82) 2004; 1012
Gaeta, Hider (bib179) 2005; 146
Drayer, Burger, Hurwitz (bib18) 1987; 149
Levenson (bib95) 2003; 61
Shin, Kruck, Murayama, Kitamoto (bib178) 2003; 961
Cameron, Cotter (bib159) 1995; 96
Duffy, Biegelsen, Holbrook (bib162) 2001; 103
Bartzokis, Tishler (bib32) 2000; 46
Pai, Nahata (bib121) 2000; 4
Inglese, Ge, Jensen (bib21) 2005; 64
Pedchenko, LeVine (bib119) 1998; 84
Koeppen, Dickson, Chu, Thach (bib139) 1993; 34
Yablonskiy, Haacke (bib48) 1997; 37
Dexter, Wells, Agid (bib5) 1987; 341
Tjoa, Benedict, Weinstock-Guttman, Fabiano, Bakshi (bib107) 2005; 234
Savoiardo (bib144) 2003; 24
Antonini, Leenders, Meier (bib42) 1993; 43
Lynch, Fonseca, Levine (bib25) 2000; 46
Song, Song (bib46) 2007; 25
Mancuso, Davidzon, Kurlan (bib122) 2005; 64
Connor, Menziew, St. Martin, Mufson (bib71) 1990; 27
Graham, Paley, Grunewald, Hoggard, Griffiths (bib38) 2000; 123
Zhou, Westaway, Levinson (bib128) 2001; 28
Michaeli, Oz, Sorce (bib50) 2007; 22
Mehindate, Sahlas, Frankel (bib110) 2001; 77
de Jesus Ferreira, Crouzin, Barbanel (bib69) 2005; 39
Hart, Lodi, Rajagopalan (bib126) 2005; 62
Cohen (bib9) 2000; 899
Vassiliev, Harris, Zatta (bib134) 2005; 49
Ke, Qian (bib56) 2003; 2
Rottkamp, Raina, Zhu (bib83) 2001; 30
Schenck (bib26) 2003; 207
Ordidge, Gorell, Deniau, Knight, Helpern (bib40) 1994; 32
Van der Worp, Thomas, Kappelle (bib68) 1999; 155
Youdim, Ben Shachar, Riedere (bib94) 1989; 126
Bakshi, Shaikh, Janardhan (bib106) 2000; 11
Brass, Benedict, Weinstock-Guttman, Munschauer, Bakshi (bib114) 2006; 12
Gutteridge (bib1) 1992; 32
Loreal, Turlin, Pigeon (bib136) 2002; 36
Crichton, Wilmet, Legssyer, Ward (bib67) 2002; 91
Soloniuk, Perkins, Wilson (bib150) 1992; 38
Bartzokis, Sultzer, Mintz (bib30) 1994; 35
Bartzokis, Sultzer, Cummings (bib88) 2000; 57
Bartzokis, Tishler, Shin, Lu, Cummings (bib89) 2004; 1012
Jensen, Chandra, Ramani (bib51) 2006; 55
Thomas, Boyko, Anthony, Burger (bib77) 1993; 14
(bib152) 1996; 27
Gal, Zheng, Fridkin, Youdim (bib181) 2005; 95
Hauser, Murtaugh, Akhter (bib146) 1996; 6
Kaur, Yantiri, Rajagopalan (bib105) 2003; 27
Chen, Hardy, Clauberg (bib29) 1989; 173
Aktas, Prozorovski, Smorodchenko (bib175) 2004; 173
Bakshi, Shaikh, Janardhan (bib113) 2000; 11
Buyse, Mertens, Di Salvo (bib163) 2003; 60
Singh, Pillay, Choonara (bib169) 2007; 81
Bartzokis, Aravagiri, Oldendorf, Mintz, Marder (bib43) 1993; 29
Levi, Yewdall, Harrison (bib58) 1992; 288
Galazka-Friedman, Bauminger, Friedman (bib93) 1996; 11
Marshall, Maas, Marshall (bib157) 1998; 89
Lehmann, Karussis, Misrachi-Koll (bib170) 1994; 50
Zecca, Stroppolo, Gatti (bib59) 2004; 101
Zecca, Youdim, Riederer, Conner, Crichton (bib73) 2004; 5
Milton, Atlas, Lexa, Mozley, Gur (bib78) 1991; 181
Riederer, Sofic, Rausch (bib4) 1989; 52
Pujol, Juque, Vendrell (bib2) 1992; 49
Ben-Shachar, Eshel, Finberg, Youdim (bib103) 1991; 56
Ma, Wehrli (bib45) 1996; 111
Curtis, Fey, Morris (bib62) 2001; 28
Dexter, Carayon, Vidailhet (bib97) 1990; 55
Xu, Pin, Gathinji, Fuchs, Harris (bib130) 2004; 1012
Schipper (bib63) 2004; 1012
Zecca, Berg, Arzberger (bib98) 2005; 20
Kuhn, Bewermeyer, Miyajima (bib137) 2007; 7
Honda, Casadesus, Petersen (bib17) 2004; 1012
LeVine (bib109) 1997; 760
Weilbach, Chan, Toyka (bib120) 2004; 135
Loeffler, Connor, Juneau (bib12) 1995; 65
Berg, Hoggenmuller, Hofmann (bib143) 2000; 42
Dedman, Treffry, Candy (bib15) 1992; 287
Berg, Hochstrasser (bib6) 2006; 21
Aguirre, Mena, Tapia (bib66) 2006; 39
Connor, Boeshore, Benkovic, Menzies (bib57) 1994; 37
Hallgren, Sourander (bib76) 1958; 3
Bowern, Ramshaw, Clark, Doherty (bib117) 1984; 160
Ruuls, Bauer, Sontrop (bib171) 1995; 56
Ben-Shachar, Kahana, Kampel, Warshawsky, Youdim (bib180) 2004; 46
Forge, Pedchenko, LeVine (bib112) 1998; 63
Rosenthal, Chanderbhan, Marshall, Fiskum (bib151) 1992; 12
Lan, Jiang (bib104) 1997; 104
Balla, Vercellotti, Muller-Eberhard, Eaton, Jacob (bib154) 1991; 64
Zecca, Zucca, Albertini, Rizzio, Fariello (bib60) 2006; 67
Neema, Stankiewicz, Arora (bib108) 2007; 17
Chakrabarty, Emerson, Levine (bib111) 2003; 9
Connor, Snyder, Beard, Fine, Mufson (bib13) 1992; 31
Bartzokis, Cummings, Markham (bib31) 1999; 17
Levy, Turtzo, Llinas (bib138) 2007; 3
Long, Ghosh, Moore, Dixon, Dash (bib155) 1996; 717
Mantyh, Ghilardi, Rogers (bib84) 1993; 61
Schenck (bib35) 1995; 134
Hardy, Gash, Yokel, Andersen, Ai, Zhang (bib37) 2005; 21
Qian, Eaton (bib158) 2000; 28
Marracci, Jones, McKeon (bib174) 2002; 13
Vymazal, Righini, Brooks (bib36) 1999; 211
Moos, Morgan (bib61) 1998; 54
Bartzokis, Beckson, Hance (bib79) 1997; 15
Grisoli, Piperno, Chiapparini, Mariani, Savoiardo (bib132) 2005; 26
Metafratzi, Argyropoulou, Kiortsis (bib34) 2001; 74
Kawanami, Kato, Daimon (bib131) 1996; 61
Cherny, Atwood, Xilinas (bib91) 2001; 30
Unger, Alexander, Fritz, Rosenberg, Dreisbach (bib140) 1994; 193
Pratico, Uryu, Leight, Trojanoswki, Lee (bib164) 2001; 21
Liddell, Hoepken, Crack, Robinson, Dringen (bib65) 2006; 84
Hikita, Abea, Sakodaa (bib47) 2005; 51
Malfroy, Doctrow, Orr, Tocco, Fedoseyeva, Benichou (bib173) 1997; 177
Whittall, MacKay, Graeb (bib39) 1997; 37
Sano, Ernesto, Thomas (bib166) 1997; 336
Block, Bakshi (bib145) 2001; 56
Harris, Durley, Man, Gitlin (bib133) 1999; 96
Hayflick, Hartman, Coryell, Gitschier, Rowley (bib127) 2006; 27
Vymazal, Brooks, Baumgarner (bib28) 1996; 35
Uitti, Rajput, Rozdilsky (bib92) 1989; 16
Willenborg, Bowern, Danta, Doherty (bib118) 1988; 17
Bartzokis (10.1016/j.nurt.2007.05.006_bib89) 2004; 1012
Levy (10.1016/j.nurt.2007.05.006_bib138) 2007; 3
Curtis (10.1016/j.nurt.2007.05.006_bib62) 2001; 28
Berg (10.1016/j.nurt.2007.05.006_bib6) 2006; 21
Ehmann (10.1016/j.nurt.2007.05.006_bib16) 1986; 7
Connor (10.1016/j.nurt.2007.05.006_bib53) 1996; 17
Schipper (10.1016/j.nurt.2007.05.006_bib63) 2004; 1012
Milton (10.1016/j.nurt.2007.05.006_bib78) 1991; 181
Harris (10.1016/j.nurt.2007.05.006_bib133) 1999; 96
Hansen (10.1016/j.nurt.2007.05.006_bib172) 1995; 62
Jenner (10.1016/j.nurt.2007.05.006_bib8) 1996; 47
Drayer (10.1016/j.nurt.2007.05.006_bib75) 1986; 147
Connor (10.1016/j.nurt.2007.05.006_bib71) 1990; 27
Andersen (10.1016/j.nurt.2007.05.006_bib96) 2001; 235
Gorell (10.1016/j.nurt.2007.05.006_bib41) 1995; 45
Hayflick (10.1016/j.nurt.2007.05.006_bib127) 2006; 27
Balla (10.1016/j.nurt.2007.05.006_bib154) 1991; 64
Ritchie (10.1016/j.nurt.2007.05.006_bib23) 2003; 60
Hart (10.1016/j.nurt.2007.05.006_bib126) 2005; 62
Youdim (10.1016/j.nurt.2007.05.006_bib10) 1993; 8
Hardy (10.1016/j.nurt.2007.05.006_bib37) 2005; 21
Tjoa (10.1016/j.nurt.2007.05.006_bib107) 2005; 234
Bartzokis (10.1016/j.nurt.2007.05.006_bib88) 2000; 57
Petersen (10.1016/j.nurt.2007.05.006_bib165) 2005; 352
Youdim (10.1016/j.nurt.2007.05.006_bib94) 1989; 126
Grisoli (10.1016/j.nurt.2007.05.006_bib132) 2005; 26
Bowern (10.1016/j.nurt.2007.05.006_bib117) 1984; 160
Zhou (10.1016/j.nurt.2007.05.006_bib128) 2001; 28
Van Landeghem (10.1016/j.nurt.2007.05.006_bib86) 1998; 9
Pai (10.1016/j.nurt.2007.05.006_bib121) 2000; 4
Shoham (10.1016/j.nurt.2007.05.006_bib102) 2004; 1012
Lynch (10.1016/j.nurt.2007.05.006_bib25) 2000; 46
Van der Worp (10.1016/j.nurt.2007.05.006_bib68) 1999; 155
Mancuso (10.1016/j.nurt.2007.05.006_bib122) 2005; 64
Honda (10.1016/j.nurt.2007.05.006_bib17) 2004; 1012
Hall (10.1016/j.nurt.2007.05.006_bib148) 1992; 32
Lehmann (10.1016/j.nurt.2007.05.006_bib170) 1994; 50
Cass (10.1016/j.nurt.2007.05.006_bib81) 2007; 28
Zecca (10.1016/j.nurt.2007.05.006_bib59) 2004; 101
Thomas (10.1016/j.nurt.2007.05.006_bib77) 1993; 14
Mehindate (10.1016/j.nurt.2007.05.006_bib110) 2001; 77
Drayer (10.1016/j.nurt.2007.05.006_bib18) 1987; 149
Willenborg (10.1016/j.nurt.2007.05.006_bib118) 1988; 17
Zecca (10.1016/j.nurt.2007.05.006_bib60) 2006; 67
Hallgren (10.1016/j.nurt.2007.05.006_bib76) 1958; 3
Zhang (10.1016/j.nurt.2007.05.006_bib116) 2007
Schenck (10.1016/j.nurt.2007.05.006_bib35) 1995; 134
Graham (10.1016/j.nurt.2007.05.006_bib38) 2000; 123
Antonini (10.1016/j.nurt.2007.05.006_bib42) 1993; 43
Koeppen (10.1016/j.nurt.2007.05.006_bib139) 1993; 34
Fernandez-Real (10.1016/j.nurt.2007.05.006_bib161) 2002; 25
Haacke (10.1016/j.nurt.2007.05.006_bib27) 2005; 23
Vymazal (10.1016/j.nurt.2007.05.006_bib28) 1996; 35
Bartzokis (10.1016/j.nurt.2007.05.006_bib79) 1997; 15
Duby (10.1016/j.nurt.2007.05.006_bib124) 2002; 11
Brass (10.1016/j.nurt.2007.05.006_bib22) 2006; 17
Zecca (10.1016/j.nurt.2007.05.006_bib73) 2004; 5
Ben-Shachar (10.1016/j.nurt.2007.05.006_bib103) 1991; 56
Zecca (10.1016/j.nurt.2007.05.006_bib98) 2005; 20
Vassiliev (10.1016/j.nurt.2007.05.006_bib134) 2005; 49
Pratico (10.1016/j.nurt.2007.05.006_bib164) 2001; 21
Kaur (10.1016/j.nurt.2007.05.006_bib105) 2003; 27
Gaeta (10.1016/j.nurt.2007.05.006_bib179) 2005; 146
Rottkamp (10.1016/j.nurt.2007.05.006_bib83) 2001; 30
Hayflick (10.1016/j.nurt.2007.05.006_bib129) 2003; 15
Wheaton (10.1016/j.nurt.2007.05.006_bib49) 2004; 52
Schenck (10.1016/j.nurt.2007.05.006_bib26) 2003; 207
Xu (10.1016/j.nurt.2007.05.006_bib130) 2004; 1012
Lan (10.1016/j.nurt.2007.05.006_bib104) 1997; 104
Cohen (10.1016/j.nurt.2007.05.006_bib9) 2000; 899
Floris (10.1016/j.nurt.2007.05.006_bib54) 2000; 60
Chinnery (10.1016/j.nurt.2007.05.006_bib123) 2007; 130
(10.1016/j.nurt.2007.05.006_bib152) 1996; 27
Haley (10.1016/j.nurt.2007.05.006_bib153) 1998; 29
Lee (10.1016/j.nurt.2007.05.006_bib177) 2004; 25
Gelman (10.1016/j.nurt.2007.05.006_bib33) 1999; 210
Bartzokis (10.1016/j.nurt.2007.05.006_bib43) 1993; 29
Rouault (10.1016/j.nurt.2007.05.006_bib74) 2001; 28
Pedchenko (10.1016/j.nurt.2007.05.006_bib119) 1998; 84
Moos (10.1016/j.nurt.2007.05.006_bib70) 2002; 49
Gal (10.1016/j.nurt.2007.05.006_bib181) 2005; 95
Bartzokis (10.1016/j.nurt.2007.05.006_bib80) 2007; 28
Levi (10.1016/j.nurt.2007.05.006_bib58) 1992; 288
Marshall (10.1016/j.nurt.2007.05.006_bib157) 1998; 89
Fahn (10.1016/j.nurt.2007.05.006_bib168) 1992; 32
Cameron (10.1016/j.nurt.2007.05.006_bib159) 1995; 96
Crichton (10.1016/j.nurt.2007.05.006_bib67) 2002; 91
Loeffler (10.1016/j.nurt.2007.05.006_bib12) 1995; 65
Sano (10.1016/j.nurt.2007.05.006_bib166) 1997; 336
Levenson (10.1016/j.nurt.2007.05.006_bib95) 2003; 61
Bakshi (10.1016/j.nurt.2007.05.006_bib113) 2000; 11
Soloniuk (10.1016/j.nurt.2007.05.006_bib150) 1992; 38
Ponka (10.1016/j.nurt.2007.05.006_bib52) 2004; 1012
Pantopoulos (10.1016/j.nurt.2007.05.006_bib55) 2004
Waldvogel (10.1016/j.nurt.2007.05.006_bib125) 1999; 46
Bjelakovic (10.1016/j.nurt.2007.05.006_bib176) 2007; 297
Dietrich (10.1016/j.nurt.2007.05.006_bib147) 1988; 168
Feng (10.1016/j.nurt.2007.05.006_bib149) 2000; 28
Singh (10.1016/j.nurt.2007.05.006_bib169) 2007; 81
Hikita (10.1016/j.nurt.2007.05.006_bib47) 2005; 51
Whittall (10.1016/j.nurt.2007.05.006_bib39) 1997; 37
Bakshi (10.1016/j.nurt.2007.05.006_bib19) 2002; 59
Liddell (10.1016/j.nurt.2007.05.006_bib65) 2006; 84
Bartzokis (10.1016/j.nurt.2007.05.006_bib31) 1999; 17
Bishop (10.1016/j.nurt.2007.05.006_bib85) 2000; 21
Hauser (10.1016/j.nurt.2007.05.006_bib146) 1996; 6
Atasoy (10.1016/j.nurt.2007.05.006_bib99) 2004; 52
Mantyh (10.1016/j.nurt.2007.05.006_bib84) 1993; 61
Cherny (10.1016/j.nurt.2007.05.006_bib91) 2001; 30
Block (10.1016/j.nurt.2007.05.006_bib145) 2001; 56
Kawanami (10.1016/j.nurt.2007.05.006_bib131) 1996; 61
LeVine (10.1016/j.nurt.2007.05.006_bib109) 1997; 760
Forge (10.1016/j.nurt.2007.05.006_bib112) 1998; 63
Dexter (10.1016/j.nurt.2007.05.006_bib97) 1990; 55
Neema (10.1016/j.nurt.2007.05.006_bib108) 2007; 17
Ruuls (10.1016/j.nurt.2007.05.006_bib171) 1995; 56
Cameron (10.1016/j.nurt.2007.05.006_bib160) 2001; 44
Ordidge (10.1016/j.nurt.2007.05.006_bib40) 1994; 32
Ben-Shachar (10.1016/j.nurt.2007.05.006_bib180) 2004; 46
Jenner (10.1016/j.nurt.2007.05.006_bib7) 1991; 136
Jensen (10.1016/j.nurt.2007.05.006_bib51) 2006; 55
Rosenthal (10.1016/j.nurt.2007.05.006_bib151) 1992; 12
Qian (10.1016/j.nurt.2007.05.006_bib158) 2000; 28
Marracci (10.1016/j.nurt.2007.05.006_bib174) 2002; 13
Ma (10.1016/j.nurt.2007.05.006_bib45) 1996; 111
Zucca (10.1016/j.nurt.2007.05.006_bib72) 2006; 113
Berg (10.1016/j.nurt.2007.05.006_bib143) 2000; 42
Bartzokis (10.1016/j.nurt.2007.05.006_bib32) 2000; 46
Weilbach (10.1016/j.nurt.2007.05.006_bib120) 2004; 135
Cornett (10.1016/j.nurt.2007.05.006_bib14) 1998; 19
Loreal (10.1016/j.nurt.2007.05.006_bib136) 2002; 36
Gutteridge (10.1016/j.nurt.2007.05.006_bib1) 1992; 32
Fenton (10.1016/j.nurt.2007.05.006_bib64) 1894; 65
Aktas (10.1016/j.nurt.2007.05.006_bib175) 2004; 173
Shin (10.1016/j.nurt.2007.05.006_bib178) 2003; 961
Savoiardo (10.1016/j.nurt.2007.05.006_bib144) 2003; 24
Levites (10.1016/j.nurt.2007.05.006_bib167) 2001; 78
Liu (10.1016/j.nurt.2007.05.006_bib182) 2006; 406
Kamran (10.1016/j.nurt.2007.05.006_bib141) 1998; 40
Vymazal (10.1016/j.nurt.2007.05.006_bib36) 1999; 211
Reichenbach (10.1016/j.nurt.2007.05.006_bib44) 1997; 7
Nielsen (10.1016/j.nurt.2007.05.006_bib142) 1995; 59
Bartzokis (10.1016/j.nurt.2007.05.006_bib30) 1994; 35
Connor (10.1016/j.nurt.2007.05.006_bib57) 1994; 37
Crapper McLachlan (10.1016/j.nurt.2007.05.006_bib24) 1991; 337
Chakrabarty (10.1016/j.nurt.2007.05.006_bib111) 2003; 9
Long (10.1016/j.nurt.2007.05.006_bib155) 1996; 717
Connor (10.1016/j.nurt.2007.05.006_bib13) 1992; 31
Kuhn (10.1016/j.nurt.2007.05.006_bib137) 2007; 7
Buyse (10.1016/j.nurt.2007.05.006_bib163) 2003; 60
Galazka-Friedman (10.1016/j.nurt.2007.05.006_bib93) 1996; 11
Pulliam (10.1016/j.nurt.2007.05.006_bib87) 2003; 119
Pujol (10.1016/j.nurt.2007.05.006_bib2) 1992; 49
Miyajima (10.1016/j.nurt.2007.05.006_bib135) 1997; 41
Malfroy (10.1016/j.nurt.2007.05.006_bib173) 1997; 177
Panter (10.1016/j.nurt.2007.05.006_bib156) 1992; 9
Dexter (10.1016/j.nurt.2007.05.006_bib5) 1987; 341
Chen (10.1016/j.nurt.2007.05.006_bib29) 1989; 173
Bermel (10.1016/j.nurt.2007.05.006_bib115) 2005; 62
Yablonskiy (10.1016/j.nurt.2007.05.006_bib48) 1997; 37
Kosta (10.1016/j.nurt.2007.05.006_bib100) 2006; 253
Inglese (10.1016/j.nurt.2007.05.006_bib21) 2005; 64
Duffy (10.1016/j.nurt.2007.05.006_bib162) 2001; 103
Wills (10.1016/j.nurt.2007.05.006_bib3) 2002; 73
Moos (10.1016/j.nurt.2007.05.006_bib61) 1998; 54
House (10.1016/j.nurt.2007.05.006_bib11) 2007; 57
Gerlach (10.1016/j.nurt.2007.05.006_bib101) 2006; 70
Bakshi (10.1016/j.nurt.2007.05.006_bib106) 2000; 11
Michaeli (10.1016/j.nurt.2007.05.006_bib50) 2007; 22
Craelius (10.1016/j.nurt.2007.05.006_bib20) 1982; 106
Ke (10.1016/j.nurt.2007.05.006_bib56) 2003; 2
Unger (10.1016/j.nurt.2007.05.006_bib140) 1994; 193
Riederer (10.1016/j.nurt.2007.05.006_bib4) 1989; 52
Richardson (10.1016/j.nurt.2007.05.006_bib82) 2004; 1012
Brass (10.1016/j.nurt.2007.05.006_bib114) 2006; 12
de Jesus Ferreira (10.1016/j.nurt.2007.05.006_bib69) 2005; 39
Aguirre (10.1016/j.nurt.2007.05.006_bib66) 2006; 39
Uitti (10.1016/j.nurt.2007.05.006_bib92) 1989; 16
Metafratzi (10.1016/j.nurt.2007.05.006_bib34) 2001; 74
House (10.1016/j.nurt.2007.05.006_bib90) 2006; 27
Dedman (10.1016/j.nurt.2007.05.006_bib15) 1992; 287
Song (10.1016/j.nurt.2007.05.006_bib46) 2007; 25
References_xml – volume: 37
  start-page: 461
  year: 1994
  end-page: 465
  ident: bib57
  article-title: Isoforms of ferritin have a specific cellular distribution in the brain
  publication-title: J Neurosci Res
– volume: 57
  start-page: 47
  year: 2000
  end-page: 53
  ident: bib88
  article-title: In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging
  publication-title: Arch Gen Psychiatry
– volume: 149
  start-page: 357
  year: 1987
  end-page: 363
  ident: bib18
  article-title: Reduced signal intensity on MR Images of thalamus and putamen in multiple sclerosis: increased iron content?
  publication-title: AJR Am J Roentgenol
– volume: 7
  start-page: 195
  year: 1986
  end-page: 206
  ident: bib16
  article-title: Brain trace elements in Alzheimer’s disease
  publication-title: Neurotoxicology
– volume: 17
  start-page: 31
  year: 2006
  end-page: 40
  ident: bib22
  article-title: Magnetic resonance imaging of iron deposition in neurological disorders
  publication-title: Top Magn Reson Imaging
– volume: 22
  start-page: 334
  year: 2007
  end-page: 340
  ident: bib50
  article-title: Assessment of brain iron and neuronal integrity in patients with Parkinson’s disease using novel MRI contrasts
  publication-title: Mov Disord
– volume: 36
  start-page: 851
  year: 2002
  end-page: 856
  ident: bib136
  article-title: Aceruloplasminemia: new clinical, pathophysiological and therapeutic insights
  publication-title: J Hepatol
– volume: 168
  start-page: 203
  year: 1988
  end-page: 206
  ident: bib147
  article-title: Iron accumulation in the basal ganglia following severe ischemic-anoxic insults in children
  publication-title: Radiology
– volume: 341
  start-page: 1219
  year: 1987
  end-page: 1220
  ident: bib5
  article-title: Increased nigral iron content in post-mortem parkinsonian brain
  publication-title: Lancet
– volume: 9
  start-page: 177
  year: 1998
  end-page: 179
  ident: bib86
  article-title: Transferrin C2, metal binding and Alzheimer’s disease
  publication-title: Neuroreport
– volume: 37
  start-page: 872
  year: 1997
  end-page: 876
  ident: bib48
  article-title: An MRI method for measuring T2 in the presence of static and RF magnetic field inhomogeneities
  publication-title: Magn Reson Med
– volume: 181
  start-page: 715
  year: 1991
  end-page: 719
  ident: bib78
  article-title: Deep gray matter hypointensity patterns with aging in healthy adults: MR imaging at 1.5T
  publication-title: Radiology
– volume: 84
  start-page: 578
  year: 2006
  end-page: 586
  ident: bib65
  article-title: Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity
  publication-title: J Neurosci Res
– volume: 147
  start-page: 103
  year: 1986
  end-page: 110
  ident: bib75
  article-title: MRI of brain iron
  publication-title: AJR Am J Roentgenol
– volume: 27
  start-page: 595
  year: 1990
  end-page: 611
  ident: bib71
  article-title: Cellular distribution of transferrin, ferritin and iron in normal and aged human brains
  publication-title: J Neurosci Res
– volume: 17
  start-page: 16
  year: 2007
  end-page: 21
  ident: bib108
  article-title: T1- and T2-based MRI measures of diffuse gray matter and white matter damage in patients with multiple sclerosis
  publication-title: J Neuroimaging
– volume: 961
  start-page: 139
  year: 2003
  end-page: 146
  ident: bib178
  article-title: A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated tau of Alzheimer’s disease
  publication-title: Brain Res
– volume: 760
  start-page: 298
  year: 1997
  end-page: 303
  ident: bib109
  article-title: Iron deposits in multiple sclerosis and Alzheimer’s disease brains
  publication-title: Brain Res
– volume: 8
  start-page: 1
  year: 1993
  end-page: 12
  ident: bib10
  article-title: Parkinson’s disease and increased iron levels in substantia nigra zona compacta
  publication-title: Mov Disord
– volume: 25
  start-page: 63
  year: 2007
  end-page: 68
  ident: bib46
  article-title: Echo-spacing optimization for the simultaneous measurement of reversible (R2’) and irreversible (R2) transverse relaxation rates
  publication-title: Magn Reson Imaging
– volume: 51
  start-page: 67
  year: 2005
  end-page: 71
  ident: bib47
  article-title: Determination of transverse relaxation rate for estimating iron deposits in central nervous system
  publication-title: Neurosci Res
– volume: 77
  start-page: 1386
  year: 2001
  end-page: 1395
  ident: bib110
  article-title: Proinflammatory cytokines promote glial heme oxygenase-1 expression and mitochondrial iron deposition: implications for multiple sclerosis
  publication-title: J Neurochem
– volume: 38
  start-page: 110
  year: 1992
  end-page: 113
  ident: bib150
  article-title: Use of allopurinol and deferoxamine in cellular protection during ischemia
  publication-title: Surg Neurol
– volume: 352
  start-page: 2379
  year: 2005
  end-page: 2388
  ident: bib165
  article-title: Vitamin E and donepezil for the treatment of mild cognitive impairment
  publication-title: N Engl J Med
– volume: 160
  start-page: 1532
  year: 1984
  end-page: 1543
  ident: bib117
  article-title: Inhibition of autoimmune neuropathological process by treatment with an iron-chelating agent
  publication-title: J Exp Med
– volume: 46
  start-page: 821
  year: 2000
  end-page: 833
  ident: bib32
  article-title: MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer’s and Huntington’s disease
  publication-title: Cell Mol Biol
– volume: 21
  start-page: 1299
  year: 2006
  end-page: 1310
  ident: bib6
  article-title: Iron metabolism in Parkinsonian syndromes
  publication-title: Mov Disord
– volume: 210
  start-page: 759
  year: 1999
  end-page: 767
  ident: bib33
  article-title: MR imaging of human brain at 3.0 T: preliminary report on transverse relaxation rates and relation to estimated iron content
  publication-title: Radiology
– volume: 54
  start-page: 486
  year: 1998
  end-page: 494
  ident: bib61
  article-title: Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid
  publication-title: J Neurosci Res
– volume: 28
  start-page: 414
  year: 2007
  end-page: 423
  ident: bib80
  article-title: Brain ferritin iron may influence age- and gender-related risks of neurodegeneration
  publication-title: Neurobiol Aging
– volume: 28
  start-page: 299
  year: 2001
  end-page: 300
  ident: bib74
  article-title: Iron on the brain
  publication-title: Nat Genet
– volume: 28
  start-page: 1431
  year: 2000
  end-page: 1438
  ident: bib149
  article-title: Desmethyl tirilazad improves neurologic function after hypoxic-ischemic brain injury in piglets
  publication-title: Crit Care Med
– volume: 173
  start-page: 5794
  year: 2004
  end-page: 5800
  ident: bib175
  article-title: Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis
  publication-title: J Immunol
– volume: 25
  start-page: 1315
  year: 2004
  end-page: 1321
  ident: bib177
  article-title: The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human b-amyloid precursor protein transgenic mice
  publication-title: Neurobiol Aging
– volume: 52
  start-page: 332
  year: 2004
  end-page: 337
  ident: bib99
  article-title: T2-weighted MRI in Parkinson’s disease; substantia nigra pars compacta hypointensity correlates with the clinical scores
  publication-title: Neurology India
– volume: 27
  start-page: 1230
  year: 2006
  end-page: 1233
  ident: bib127
  article-title: Brain MRI in neurodegeneration with brain iron accumulation with and without PANK2 mutations
  publication-title: AJNR Am J Neuroradiol
– volume: 31
  start-page: 327
  year: 1992
  end-page: 335
  ident: bib13
  article-title: Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer’s disease
  publication-title: J Neurosci Res
– volume: 25
  start-page: 2249
  year: 2002
  end-page: 2255
  ident: bib161
  article-title: Blood letting in high-ferritin type 2 diabetes: effects on vascular reactivity
  publication-title: Diabetes Care
– volume: 30
  start-page: 665
  year: 2001
  end-page: 676
  ident: bib91
  article-title: Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer’s disease transgenic mice
  publication-title: Neuron
– volume: 96
  start-page: 10812
  year: 1999
  end-page: 10817
  ident: bib133
  article-title: Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux
  publication-title: Proc Natl Acad Sci USA
– volume: 899
  start-page: 112
  year: 2000
  end-page: 120
  ident: bib9
  article-title: Oxidative stress, mitochondrial respiration, and Parkinson’s disease
  publication-title: Ann NY Acad Sci
– year: 2007
  ident: bib116
  article-title: Deep gray matter “black T2” on 3 tesla magnetic resonance image correlates with disability in multiple sclerosis
  publication-title: Mult Scler
– volume: 70
  start-page: 133
  year: 2006
  end-page: 142
  ident: bib101
  article-title: Potential sources of increased iron in the substantia nigra of parkinsonian patients
  publication-title: J Neural Transm Suppl
– volume: 106
  start-page: 397
  year: 1982
  end-page: 399
  ident: bib20
  article-title: Iron deposits surrounding multiple sclerosis plaques
  publication-title: Arch Pathol Lab Med
– volume: 34
  start-page: 646
  year: 1993
  end-page: 653
  ident: bib139
  article-title: The pathogenesis of superficial siderosis of the central nervous system
  publication-title: Ann Neurol
– volume: 406
  start-page: 189
  year: 2006
  end-page: 193
  ident: bib182
  article-title: Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance
  publication-title: Neurosci Lett
– volume: 111
  start-page: 61
  year: 1996
  end-page: 69
  ident: bib45
  article-title: Method for image-based measurement of the reversible and irreversible contribution to the transverse-relaxation rate
  publication-title: J Magn Reson Imaging
– volume: 50
  start-page: 35
  year: 1994
  end-page: 42
  ident: bib170
  article-title: Oral administration of the oxidant scavenger N-acetyl-L-cysteine inhibits acute experimental autoimmune encephalomyelitis
  publication-title: J Neuroimmunol
– volume: 253
  start-page: 26
  year: 2006
  end-page: 32
  ident: bib100
  article-title: MRI evaluation of the basal ganglia size and iron content in patients with Parkinson’s disease
  publication-title: J Neurol
– volume: 29
  start-page: 1256
  year: 1998
  end-page: 1257
  ident: bib153
  article-title: High-dose tirilazad for acute stroke (RANTTAS II)
  publication-title: Stroke
– volume: 39
  start-page: 1009
  year: 2005
  end-page: 1020
  ident: bib69
  article-title: A transient treatment of hippocampal neurons with alpha-tocopherol induces a long-lasting protection against oxidative damage via a genomic action
  publication-title: Free Radic Biol Med
– volume: 59
  start-page: 318
  year: 1995
  end-page: 321
  ident: bib142
  article-title: Hereditary haemochromatosis: a case of iron accumulation in the basal ganglia associated with a parkinsonian syndrome
  publication-title: J Neurol Neurosurg Psychiatry
– volume: 717
  start-page: 109
  year: 1996
  end-page: 117
  ident: bib155
  article-title: Deferoxamine improves spatial memory performance following experimental brain injury in rats
  publication-title: Brain Res
– volume: 27
  start-page: 430
  year: 2006
  end-page: 439
  ident: bib90
  article-title: Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss
  publication-title: AJNR Am J Neuroradiol
– volume: 11
  start-page: 15
  year: 2000
  end-page: 21
  ident: bib106
  article-title: MRI T2 shortening (“black T2”) in multiple sclerosis: frequency, location, and clinical correlation
  publication-title: Neuroreport
– volume: 234
  start-page: 17
  year: 2005
  end-page: 24
  ident: bib107
  article-title: MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis
  publication-title: J Neurol Sci
– volume: 21
  start-page: 4183
  year: 2001
  end-page: 4187
  ident: bib164
  article-title: Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis
  publication-title: J Neurosci
– volume: 235
  start-page: 11
  year: 2001
  end-page: 20
  ident: bib96
  article-title: Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson’s disease?
  publication-title: Novartis Found Symp
– volume: 7
  start-page: 266
  year: 1997
  end-page: 279
  ident: bib44
  article-title: Theory and application of static field inhomogeneity effects in gradient-echo imaging
  publication-title: J Magn Reson Imaging
– volume: 9
  start-page: 372
  year: 2003
  end-page: 381
  ident: bib111
  article-title: Heme oxygenase-1 in SJL mice with experimental allergic encephalomyelitis
  publication-title: Multiple Sclerosis
– volume: 24
  start-page: S35
  year: 2003
  end-page: S37
  ident: bib144
  article-title: Differential diagnosis of Parkinson’s disease and atypical parkinsonian disorder by magnetic resonance imaging
  publication-title: Neurol Sci
– volume: 61
  start-page: 311
  year: 2003
  end-page: 313
  ident: bib95
  article-title: Iron and Parkinson’s disease: Chelators to the rescue?
  publication-title: Nutr Rev
– volume: 1012
  start-page: 94
  year: 2004
  end-page: 114
  ident: bib102
  article-title: Nutritional iron deprivation attenuates kainate-induced neurotoxicity in rats: implications for involvement of iron in neurodegeneration
  publication-title: Ann NY Acad Sci
– volume: 297
  start-page: 842
  year: 2007
  end-page: 857
  ident: bib176
  article-title: Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
  publication-title: JAMA
– volume: 104
  start-page: 469
  year: 1997
  end-page: 481
  ident: bib104
  article-title: Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice
  publication-title: J Neural Transm
– volume: 55
  start-page: 1350
  year: 2006
  end-page: 1361
  ident: bib51
  article-title: Magnetic field correlation imaging
  publication-title: Magn Reson Med
– volume: 28
  start-page: 350
  year: 2001
  end-page: 354
  ident: bib62
  article-title: Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease
  publication-title: Nat Genet
– volume: 6
  start-page: 222
  year: 1996
  end-page: 226
  ident: bib146
  article-title: Magnetic resonance imaging of corticobasal degeneration
  publication-title: J Neuroimaging
– volume: 21
  start-page: 118
  year: 2005
  end-page: 127
  ident: bib37
  article-title: Correlation of R2 with total iron concentration in the brains of rhesus monkeys
  publication-title: J Magn Reson Imaging
– volume: 64
  start-page: A236
  year: 2005
  ident: bib21
  article-title: Iron accumulation in the deep gray matter of patients with MS measured by magnetic field correlation
  publication-title: Neurology
– volume: 27
  start-page: 899
  year: 2003
  end-page: 909
  ident: bib105
  article-title: Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson’s disease
  publication-title: Neuron
– volume: 61
  start-page: 506
  year: 1996
  end-page: 509
  ident: bib131
  article-title: Hereditary caeruloplasmin deficiency: clinicopathological study of a patient
  publication-title: J Neurol Neurosurg Psychiatry
– volume: 15
  start-page: 29
  year: 1997
  end-page: 35
  ident: bib79
  article-title: MR evaluation of age-related increase of brain iron in young adult and older normal males
  publication-title: Magn Reson Imaging
– volume: 56
  start-page: 207
  year: 1995
  end-page: 217
  ident: bib171
  article-title: Reactive oxygen species are involved in the pathogenesis of experimental allergic encephalomyelitis in Lewis rats
  publication-title: J Neuroimmunol
– volume: 207
  start-page: 99
  year: 2003
  end-page: 102
  ident: bib26
  article-title: Magnetic resonance imaging of brain iron
  publication-title: J Neurol Sci
– volume: 23
  start-page: 1
  year: 2005
  end-page: 25
  ident: bib27
  article-title: Imaging iron stores in the brain using magnetic resonance imaging
  publication-title: Magn Reson Imaging
– volume: 211
  start-page: 489
  year: 1999
  end-page: 495
  ident: bib36
  article-title: T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: relation to iron content
  publication-title: Radiology
– volume: 12
  start-page: 29
  year: 1992
  end-page: 33
  ident: bib151
  article-title: Prevention of post-ischemic brain lipid conjugated diene production and neurological injury by hydroxyethyl starch-conjugated deferoxamine
  publication-title: Free Radic Biol Med
– volume: 28
  start-page: 345
  year: 2001
  end-page: 349
  ident: bib128
  article-title: A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome
  publication-title: Nat Genet
– volume: 123
  start-page: 2423
  year: 2000
  end-page: 2431
  ident: bib38
  article-title: Brain iron deposition in Parkinson’s disease imaged using the PRIME magnetic resonance sequence
  publication-title: Brain
– volume: 57
  start-page: 172
  year: 2007
  end-page: 180
  ident: bib11
  article-title: Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from Alzheimer’s disease patients
  publication-title: Magn Reson Med
– volume: 2
  start-page: 246
  year: 2003
  end-page: 253
  ident: bib56
  article-title: Iron misregulation in the brain: a primary cause of neurodegenerative disorders
  publication-title: Lancet Neurol
– volume: 103
  start-page: 2799
  year: 2001
  end-page: 2804
  ident: bib162
  article-title: Iron chelation improves endothelial function in patients with coronary artery disease
  publication-title: Circulation
– volume: 62
  start-page: 69
  year: 1995
  end-page: 77
  ident: bib172
  article-title: Suppression of hyperacute and passively transferred experimental autoimmune encephalomyelitis by the antioxidant, butylated hydroxyanisole
  publication-title: J Neuroimmunol
– volume: 19
  start-page: 339
  year: 1998
  end-page: 346
  ident: bib14
  article-title: Imbalances of trace elements related to oxidative damage in Alzheimer’s disease brain
  publication-title: Neurotoxicology
– volume: 29
  start-page: 459
  year: 1993
  end-page: 464
  ident: bib43
  article-title: Field dependent transverse relaxation rate increase may be a specific measure of tissue iron stores
  publication-title: Magn Reson Med
– volume: 27
  start-page: 1453
  year: 1996
  end-page: 1458
  ident: bib152
  article-title: A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS)
  publication-title: Stroke
– volume: 39
  start-page: 103
  year: 2006
  end-page: 104
  ident: bib66
  article-title: Antioxidant responses of cortex neurons to iron loading
  publication-title: Biol Res
– volume: 84
  start-page: 188
  year: 1998
  end-page: 197
  ident: bib119
  article-title: Desferrioxamine suppresses experimental allergic encephalomyelitis induced by MBP in SJL mice
  publication-title: J Neuroimmunol
– volume: 30
  start-page: 447
  year: 2001
  end-page: 450
  ident: bib83
  article-title: Redox-active iron mediates amyloid-β toxicity
  publication-title: Free Radical Biol Med
– volume: 177
  start-page: 62
  year: 1997
  end-page: 68
  ident: bib173
  article-title: Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites
  publication-title: Cell Immunol
– volume: 41
  start-page: 404
  year: 1997
  end-page: 407
  ident: bib135
  article-title: Use of desferrioxamine in the treatment of aceruloplasminemia
  publication-title: Ann Neurol
– volume: 46
  start-page: 865
  year: 2000
  end-page: 869
  ident: bib25
  article-title: A multiple course trial of desferrioxamine in chronic progressive multiple sclerosis
  publication-title: Cell Mol Biol
– volume: 32
  start-page: S137
  year: 1992
  end-page: S142
  ident: bib148
  article-title: Novel inhibitors of iron-dependent lipid peroxidation for neurodegenerative disorders
  publication-title: Ann Neurol
– volume: 7
  start-page: 450
  year: 2007
  end-page: 453
  ident: bib137
  article-title: Treatment of symptomatic heterozygous aceruloplasminemia with oral zinc sulphate
  publication-title: Brain Dev
– volume: 43
  start-page: 697
  year: 1993
  end-page: 700
  ident: bib42
  article-title: T2 relaxation time in patients with Parkinson disease
  publication-title: Neurology
– volume: 44
  start-page: 621
  year: 2001
  end-page: 628
  ident: bib160
  article-title: Effects of an extracellular metal chelator on neurovascular function in diabetic rats
  publication-title: Diabetologia
– volume: 17
  start-page: 213
  year: 1999
  end-page: 222
  ident: bib31
  article-title: MRI evaluation of brain iron in earlier- and later-onset Parkinson’s disease and normal subjects
  publication-title: Magn Reson Imaging
– volume: 3
  start-page: 54
  year: 2007
  end-page: 58
  ident: bib138
  article-title: Superficial siderosis: a case report and review of the literature
  publication-title: Nat Clin Pract Neurol
– volume: 65
  start-page: 710
  year: 1995
  end-page: 716
  ident: bib12
  article-title: Transferrin and iron in normal, Alzheimer’s disease, and Parkinson’s disease brain regions
  publication-title: J Neurochem
– volume: 61
  start-page: 1171
  year: 1993
  end-page: 1174
  ident: bib84
  article-title: Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of β-amyloid peptide
  publication-title: J Neurochem
– volume: 11
  start-page: 8
  year: 1996
  end-page: 16
  ident: bib93
  article-title: Iron in parkinsonian and control substantia nigra: a Mossbauer spectroscopy study
  publication-title: Mov Disord
– volume: 173
  start-page: 521
  year: 1989
  end-page: 526
  ident: bib29
  article-title: T2 values in the human brain: comparison with quantitative assays of iron and ferritin
  publication-title: Radiology
– volume: 4
  start-page: 263
  year: 2000
  end-page: 302
  ident: bib121
  article-title: Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention
  publication-title: Drug Saf
– volume: 65
  start-page: 899
  year: 1894
  end-page: 903
  ident: bib64
  article-title: Oxidation of tartaric acid in presence of iron
  publication-title: J Chem Soc
– volume: 126
  start-page: 47
  year: 1989
  end-page: 54
  ident: bib94
  article-title: Is Parkinson’s disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration
  publication-title: Acta Neurol Scand
– volume: 49
  start-page: 711
  year: 1992
  end-page: 717
  ident: bib2
  article-title: Biological significance of iron-related magnetic resonance imaging changes in the brain
  publication-title: Arch Neurol
– volume: 52
  start-page: 515
  year: 1989
  end-page: 520
  ident: bib4
  article-title: Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
  publication-title: J Neurochem
– volume: 3
  start-page: 41
  year: 1958
  end-page: 51
  ident: bib76
  article-title: The effect of age on the non-haemin iron in the human brain
  publication-title: J Neurochem
– volume: 28
  start-page: 258
  year: 2007
  end-page: 271
  ident: bib81
  article-title: Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys
  publication-title: Neurobiol Aging
– volume: 136
  start-page: 6
  year: 1991
  end-page: 15
  ident: bib7
  article-title: Oxidative stress as a cause of Parkinson’s disease
  publication-title: Acta Neurol Scand Suppl
– volume: 89
  start-page: 519
  year: 1998
  end-page: 525
  ident: bib157
  article-title: A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury
  publication-title: J Neurosurg
– volume: 13
  start-page: 104
  year: 2002
  end-page: 114
  ident: bib174
  article-title: Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis
  publication-title: J Neuroimmunol
– volume: 337
  start-page: 1304
  year: 1991
  end-page: 1308
  ident: bib24
  article-title: Intramuscular desferrioxamine in patients with Alzheimer’s disease
  publication-title: Lancet
– volume: 45
  start-page: 1138
  year: 1995
  end-page: 1143
  ident: bib41
  article-title: Increased iron-related MRI contrast in the substantia nigra in Parkinson’s disease
  publication-title: Neurology
– volume: 101
  start-page: 9843
  year: 2004
  end-page: 9848
  ident: bib59
  article-title: The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging
  publication-title: Proc Natl Acad Sci U S A
– volume: 17
  start-page: 83
  year: 1996
  end-page: 93
  ident: bib53
  article-title: Relationship of iron to oligodendrocytes and myelination
  publication-title: Glia
– volume: 74
  start-page: 407
  year: 2001
  end-page: 410
  ident: bib34
  article-title: T(2) relaxation rate of basal ganglia and cortex in patients with beta-thalassaemia major
  publication-title: Br J Radiol
– volume: 113
  start-page: 757
  year: 2006
  end-page: 767
  ident: bib72
  article-title: Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability
  publication-title: J Neural Transm
– volume: 288
  start-page: 591
  year: 1992
  end-page: 596
  ident: bib58
  article-title: Evidence that H- and L-chains have co-operative roles in the iron-uptake mechanism of human ferritin
  publication-title: J Biochem
– volume: 17
  start-page: 127
  year: 1988
  end-page: 135
  ident: bib118
  article-title: Inhibition of allergic encephalomyelitis by the iron chelating agent desferrioxamine: differential effect depending on type of sensitizing encephalitogen
  publication-title: J Neuroimmunol
– volume: 287
  start-page: 509
  year: 1992
  end-page: 514
  ident: bib15
  article-title: Iron and aluminum in relation to brain ferritin in normal individuals and Alzheimer’s-disease and chronic renal-dialysis patients
  publication-title: Biochem J
– volume: 81
  start-page: 29
  year: 2007
  end-page: 44
  ident: bib169
  article-title: Advances in the treatment of Parkinson’s disease
  publication-title: Prog Neurobiol
– volume: 52
  start-page: 1223
  year: 2004
  end-page: 1227
  ident: bib49
  article-title: T2rho-weighted contrast in MR images of the human brain
  publication-title: Magn Reson Med
– volume: 63
  start-page: 2271
  year: 1998
  end-page: 2284
  ident: bib112
  article-title: Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis
  publication-title: Life Sci
– volume: 14
  start-page: 1043
  year: 1993
  end-page: 1048
  ident: bib77
  article-title: MR detection of brain iron
  publication-title: AJNR Am J Neuroradiol
– volume: 95
  start-page: 79
  year: 2005
  end-page: 88
  ident: bib181
  article-title: Novel multifunctional neuroprotective iron chelator–monoamine oxidase inhibitor drugs for neurodegenerative diseases
  publication-title: J Neurochem
– volume: 59
  start-page: 62
  year: 2002
  end-page: 68
  ident: bib19
  article-title: T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study
  publication-title: Arch Neurol
– volume: 21
  start-page: 226
  year: 2000
  ident: bib85
  article-title: β-Amyloid helps to protect neurons from oxidative stress
  publication-title: Neurobiol Aging
– volume: 56
  start-page: 1441
  year: 1991
  end-page: 1444
  ident: bib103
  article-title: The iron chelator desferrioxamine (desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons
  publication-title: J Neurochem
– volume: 78
  start-page: 1073
  year: 2001
  end-page: 1082
  ident: bib167
  article-title: Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration
  publication-title: J Neurochem
– volume: 64
  start-page: 280
  year: 2005
  end-page: 294
  ident: bib122
  article-title: Hereditary ferritinopathy: a novel mutation, its cellular pathology, and pathogenetic insights
  publication-title: J Neuropathol Exp Neurol
– volume: 135
  start-page: 49
  year: 2004
  end-page: 55
  ident: bib120
  article-title: The cardioprotector dexrazoxane augments therapeutic efficacy of mitoxantrone in experimental autoimmune encephalomyelitis
  publication-title: Clin Exp Immunol
– volume: 42
  start-page: 9
  year: 2000
  end-page: 13
  ident: bib143
  article-title: The basal ganglia in haemochromatosis
  publication-title: Neuroradiology
– volume: 1012
  start-page: 84
  year: 2004
  end-page: 93
  ident: bib63
  article-title: Heme oxygemase-1: transducer of pathological brain iron sequestration under oxidative stress
  publication-title: Ann NY Acad Sci
– volume: 55
  start-page: 16
  year: 1990
  end-page: 20
  ident: bib97
  article-title: Decreased ferritin levels in brain in Parkinson’s disease
  publication-title: J Neurochem
– volume: 62
  start-page: 1371
  year: 2005
  end-page: 1376
  ident: bib115
  article-title: Prediction of longitudinal brain atrophy in multiple sclerosis by gray matter magnetic resonance imaging T2 hypointensity
  publication-title: Arch Neurol
– volume: 73
  start-page: 91
  year: 2002
  end-page: 92
  ident: bib3
  article-title: Palatal tremor and cognitive decline in neuroferritinopathy
  publication-title: J Neurol Neurosurg Psychiatry
– volume: 1012
  start-page: 224
  year: 2004
  end-page: 236
  ident: bib89
  article-title: Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases
  publication-title: Ann NY Acad Sci
– volume: 134
  start-page: 10
  year: 1995
  end-page: 18
  ident: bib35
  article-title: Imaging of brain iron by magnetic resonance: T2 relaxation at different field strengths
  publication-title: J Neurol Sci
– volume: 32
  start-page: 335
  year: 1994
  end-page: 341
  ident: bib40
  article-title: Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla
  publication-title: Magn Reson Med
– volume: 1012
  start-page: 267
  year: 2004
  end-page: 281
  ident: bib52
  article-title: Heredity causes of disturbed iron homeostasis in the central nervous system
  publication-title: Ann NY Acad Sci
– volume: 60
  start-page: 1685
  year: 2003
  end-page: 1691
  ident: bib23
  article-title: Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
  publication-title: Arch Neurol
– volume: 193
  start-page: 473
  year: 1994
  end-page: 476
  ident: bib140
  article-title: Toluene abuse: physical basis for hypointensity of the basal ganglia on T2-weighted images
  publication-title: Radiology
– volume: 37
  start-page: 34
  year: 1997
  end-page: 43
  ident: bib39
  article-title: measurement of T2 distributions and water contents in normal human brain
  publication-title: Magn Reson Med
– volume: 155
  start-page: 103
  year: 1999
  end-page: 108
  ident: bib68
  article-title: Inhibition of iron-dependent and ischemia-induced brain damage by the alpha-tocopherol analogue MDL74,722
  publication-title: Exp Neurol
– volume: 15
  start-page: 572
  year: 2003
  end-page: 577
  ident: bib129
  article-title: Unraveling the Hallervorden-Spatz syndrome: pantothenate kinase-associated neurodegeneration is the name
  publication-title: Curr Opin Pediatr
– volume: 49
  start-page: 279
  year: 2002
  end-page: 301
  ident: bib70
  article-title: Brain iron homeostasis
  publication-title: Dan Med Bull
– volume: 130
  start-page: 110
  year: 2007
  end-page: 119
  ident: bib123
  article-title: Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation
  publication-title: Brain
– volume: 32
  start-page: 799
  year: 1992
  end-page: 803
  ident: bib168
  article-title: The oxidant stress hypothesis in idiopathic Parkinson’s: evidence supporting it
  publication-title: Ann Neurol
– volume: 35
  start-page: 480
  year: 1994
  end-page: 487
  ident: bib30
  article-title: evaluation of brain iron in Alzheimer’s disease and normal subjects using MRI
  publication-title: Biol Psych
– volume: 119
  start-page: 48
  year: 2003
  end-page: 53
  ident: bib87
  article-title: Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer’s disease and correlation with APOE
  publication-title: Am J Med Genet B Neuropsychiatr Genet
– volume: 28
  start-page: 652
  year: 2000
  end-page: 656
  ident: bib158
  article-title: Glycochelates and the etiology of diabetic peripheral neuropathy
  publication-title: Free Radic Biol Med
– volume: 60
  start-page: 1679
  year: 2003
  end-page: 1681
  ident: bib163
  article-title: Idebenone treatment in Friedreich’s ataxia
  publication-title: Neurology
– volume: 67
  start-page: S8
  year: 2006
  end-page: S11
  ident: bib60
  article-title: A proposed dual role of neuromelanin in the pathogenesis of Parkinson’s disease
  publication-title: Neurology
– volume: 26
  start-page: 657
  year: 2005
  end-page: 661
  ident: bib132
  article-title: MR imaging of cerebral cortical involvement in aceruloplasminemia
  publication-title: AJNR Am J Neuroradiol
– volume: 1012
  start-page: 326
  year: 2004
  end-page: 341
  ident: bib82
  article-title: Novel chelators for central nervous system disorders that involve alterations in the metabolism of iron and other metal ions
  publication-title: Ann NY Acad Sci
– volume: 146
  start-page: 1041
  year: 2005
  end-page: 1059
  ident: bib179
  article-title: The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy
  publication-title: Br J Pharmacol
– volume: 91
  start-page: 9
  year: 2002
  end-page: 18
  ident: bib67
  article-title: Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells
  publication-title: J Inorg Biochem
– volume: 1012
  start-page: 299
  year: 2004
  end-page: 305
  ident: bib130
  article-title: Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis
  publication-title: Ann N Y Acad Sci
– volume: 46
  start-page: 123
  year: 1999
  end-page: 125
  ident: bib125
  article-title: Increased iron in the dentate nucleus of patients with Friedrich’s ataxia
  publication-title: Ann Neurol
– volume: 47
  start-page: S161
  year: 1996
  end-page: S170
  ident: bib8
  article-title: Oxidative stress and the pathogenesis of Parkinson’s disease
  publication-title: Neurology
– volume: 35
  start-page: 56
  year: 1996
  end-page: 61
  ident: bib28
  article-title: The relation between brain iron and NMR relaxation times: an
  publication-title: Magn Reson Med
– volume: 9
  start-page: 47
  year: 1992
  end-page: 53
  ident: bib156
  article-title: Dextran-coupled deferoxamine improves outcome in a murine model of head injury
  publication-title: J Neurotrauma
– volume: 62
  start-page: 621
  year: 2005
  end-page: 626
  ident: bib126
  article-title: Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up
  publication-title: Arch Neurol
– start-page: 1012
  year: 2004
  end-page: 1013
  ident: bib55
  article-title: Iron metabolism and the IRE/IRP regulator system: an update
  publication-title: Ann NY Acad Sci
– volume: 12
  start-page: 437
  year: 2006
  end-page: 444
  ident: bib114
  article-title: Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis
  publication-title: Mult Scler
– volume: 5
  start-page: 863
  year: 2004
  end-page: 873
  ident: bib73
  article-title: Iron, brain ageing and neurodegenerative disorders
  publication-title: Nat Rev Neurosci
– volume: 20
  start-page: 1278
  year: 2005
  end-page: 1285
  ident: bib98
  article-title: In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage
  publication-title: Mov Disord
– volume: 11
  start-page: 2635
  year: 2002
  end-page: 2643
  ident: bib124
  article-title: A non-essential function for yeast frataxin in iron-sulfur cluster assembly
  publication-title: Hum Mol Genet
– volume: 60
  start-page: 1735
  year: 2000
  end-page: 1741
  ident: bib54
  article-title: The physiopathological significance of ceruloplasmin
  publication-title: Biochem Pharmacol
– volume: 32
  start-page: S16
  year: 1992
  end-page: S21
  ident: bib1
  article-title: Iron and oxygen radicals in brain
  publication-title: Ann Neurol
– volume: 11
  start-page: 15
  year: 2000
  end-page: 21
  ident: bib113
  article-title: MRI T2 shortening (“black T2”) in multiple sclerosis: frequency, location, and clinical correlation
  publication-title: Neuroreport
– volume: 40
  start-page: 519
  year: 1998
  end-page: 521
  ident: bib141
  article-title: MRI in chronic toluene abuse: low signal in the cerebral cortex on T2-weighted images
  publication-title: Neuroradiology
– volume: 56
  start-page: 1200
  year: 2001
  ident: bib145
  article-title: FLAIR MRI of striatonigral degeneration
  publication-title: Neurology
– volume: 1012
  start-page: 179
  year: 2004
  end-page: 182
  ident: bib17
  article-title: Oxidative stress and redox-active iron in Alzheimer’s disease
  publication-title: Ann NY Acad Sci
– volume: 16
  start-page: 310
  year: 1989
  end-page: 314
  ident: bib92
  article-title: Regional metal concentrations in Parkinson’s disease, other chronic neurological diseases, and control brains
  publication-title: Can J Neurol Sci
– volume: 49
  start-page: 633
  year: 2005
  end-page: 640
  ident: bib134
  article-title: Ceruloplasmin in neurodegenerative diseases
  publication-title: Brain Res Brain Res Rev
– volume: 46
  start-page: 254
  year: 2004
  end-page: 263
  ident: bib180
  article-title: Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lesion in rats
  publication-title: Neuropharmacology
– volume: 64
  start-page: 648
  year: 1991
  end-page: 655
  ident: bib154
  article-title: Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species
  publication-title: Lab Invest
– volume: 96
  start-page: 1159
  year: 1995
  end-page: 1163
  ident: bib159
  article-title: Neurovascular dysfunction in diabetic rats
  publication-title: J Clin Invest
– volume: 336
  start-page: 1216
  year: 1997
  end-page: 1222
  ident: bib166
  article-title: A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease
  publication-title: N Engl J Med
– volume: 35
  start-page: 56
  year: 1996
  end-page: 61
  ident: bib28
  article-title: The relation between brain iron and NMR relaxation times: an
  publication-title: Magn Reson Med
– volume: 35
  start-page: 480
  year: 1994
  end-page: 487
  ident: bib30
  publication-title: Biol Psych
– volume: 37
  start-page: 34
  year: 1997
  end-page: 43
  ident: bib39
  publication-title: Magn Reson Med
– volume: 5
  start-page: 863
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib73
  article-title: Iron, brain ageing and neurodegenerative disorders
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn1537
– volume: 56
  start-page: 207
  year: 1995
  ident: 10.1016/j.nurt.2007.05.006_bib171
  article-title: Reactive oxygen species are involved in the pathogenesis of experimental allergic encephalomyelitis in Lewis rats
  publication-title: J Neuroimmunol
  doi: 10.1016/0165-5728(94)00154-G
– volume: 35
  start-page: 480
  year: 1994
  ident: 10.1016/j.nurt.2007.05.006_bib30
  article-title: In vivo evaluation of brain iron in Alzheimer’s disease and normal subjects using MRI
  publication-title: Biol Psych
  doi: 10.1016/0006-3223(94)90047-7
– volume: 42
  start-page: 9
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib143
  article-title: The basal ganglia in haemochromatosis
  publication-title: Neuroradiology
  doi: 10.1007/s002340050002
– volume: 43
  start-page: 697
  year: 1993
  ident: 10.1016/j.nurt.2007.05.006_bib42
  article-title: T2 relaxation time in patients with Parkinson disease
  publication-title: Neurology
  doi: 10.1212/WNL.43.4.697
– volume: 14
  start-page: 1043
  year: 1993
  ident: 10.1016/j.nurt.2007.05.006_bib77
  article-title: MR detection of brain iron
  publication-title: AJNR Am J Neuroradiol
– volume: 26
  start-page: 657
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib132
  article-title: MR imaging of cerebral cortical involvement in aceruloplasminemia
  publication-title: AJNR Am J Neuroradiol
– volume: 13
  start-page: 104
  year: 2002
  ident: 10.1016/j.nurt.2007.05.006_bib174
  article-title: Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis
  publication-title: J Neuroimmunol
  doi: 10.1016/S0165-5728(02)00269-2
– volume: 57
  start-page: 172
  year: 2007
  ident: 10.1016/j.nurt.2007.05.006_bib11
  article-title: Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from Alzheimer’s disease patients
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.21118
– volume: 52
  start-page: 515
  year: 1989
  ident: 10.1016/j.nurt.2007.05.006_bib4
  article-title: Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.1989.tb09150.x
– volume: 2
  start-page: 246
  year: 2003
  ident: 10.1016/j.nurt.2007.05.006_bib56
  article-title: Iron misregulation in the brain: a primary cause of neurodegenerative disorders
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(03)00353-3
– volume: 11
  start-page: 8
  year: 1996
  ident: 10.1016/j.nurt.2007.05.006_bib93
  article-title: Iron in parkinsonian and control substantia nigra: a Mossbauer spectroscopy study
  publication-title: Mov Disord
  doi: 10.1002/mds.870110104
– volume: 1012
  start-page: 299
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib130
  article-title: Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis
  publication-title: Ann N Y Acad Sci
  doi: 10.1196/annals.1306.024
– volume: 34
  start-page: 646
  year: 1993
  ident: 10.1016/j.nurt.2007.05.006_bib139
  article-title: The pathogenesis of superficial siderosis of the central nervous system
  publication-title: Ann Neurol
  doi: 10.1002/ana.410340505
– volume: 25
  start-page: 2249
  year: 2002
  ident: 10.1016/j.nurt.2007.05.006_bib161
  article-title: Blood letting in high-ferritin type 2 diabetes: effects on vascular reactivity
  publication-title: Diabetes Care
  doi: 10.2337/diacare.25.12.2249
– volume: 106
  start-page: 397
  year: 1982
  ident: 10.1016/j.nurt.2007.05.006_bib20
  article-title: Iron deposits surrounding multiple sclerosis plaques
  publication-title: Arch Pathol Lab Med
– volume: 1012
  start-page: 84
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib63
  article-title: Heme oxygemase-1: transducer of pathological brain iron sequestration under oxidative stress
  publication-title: Ann NY Acad Sci
  doi: 10.1196/annals.1306.007
– volume: 17
  start-page: 31
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib22
  article-title: Magnetic resonance imaging of iron deposition in neurological disorders
  publication-title: Top Magn Reson Imaging
  doi: 10.1097/01.rmr.0000245459.82782.e4
– volume: 28
  start-page: 652
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib158
  article-title: Glycochelates and the etiology of diabetic peripheral neuropathy
  publication-title: Free Radic Biol Med
  doi: 10.1016/S0891-5849(99)00262-2
– volume: 717
  start-page: 109
  year: 1996
  ident: 10.1016/j.nurt.2007.05.006_bib155
  article-title: Deferoxamine improves spatial memory performance following experimental brain injury in rats
  publication-title: Brain Res
  doi: 10.1016/0006-8993(95)01500-0
– volume: 84
  start-page: 578
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib65
  article-title: Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.20957
– volume: 1012
  start-page: 326
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib82
  article-title: Novel chelators for central nervous system disorders that involve alterations in the metabolism of iron and other metal ions
  publication-title: Ann NY Acad Sci
  doi: 10.1196/annals.1306.026
– volume: 24
  start-page: S35
  issue: suppl 1
  year: 2003
  ident: 10.1016/j.nurt.2007.05.006_bib144
  article-title: Differential diagnosis of Parkinson’s disease and atypical parkinsonian disorder by magnetic resonance imaging
  publication-title: Neurol Sci
  doi: 10.1007/s100720300036
– volume: 62
  start-page: 1371
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib115
  article-title: Prediction of longitudinal brain atrophy in multiple sclerosis by gray matter magnetic resonance imaging T2 hypointensity
  publication-title: Arch Neurol
  doi: 10.1001/archneur.62.9.1371
– volume: 17
  start-page: 83
  year: 1996
  ident: 10.1016/j.nurt.2007.05.006_bib53
  article-title: Relationship of iron to oligodendrocytes and myelination
  publication-title: Glia
  doi: 10.1002/(SICI)1098-1136(199606)17:2<83::AID-GLIA1>3.0.CO;2-7
– volume: 160
  start-page: 1532
  year: 1984
  ident: 10.1016/j.nurt.2007.05.006_bib117
  article-title: Inhibition of autoimmune neuropathological process by treatment with an iron-chelating agent
  publication-title: J Exp Med
  doi: 10.1084/jem.160.5.1532
– volume: 37
  start-page: 34
  year: 1997
  ident: 10.1016/j.nurt.2007.05.006_bib39
  article-title: In vivo measurement of T2 distributions and water contents in normal human brain
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.1910370107
– volume: 28
  start-page: 299
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib74
  article-title: Iron on the brain
  publication-title: Nat Genet
  doi: 10.1038/91036
– volume: 253
  start-page: 26
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib100
  article-title: MRI evaluation of the basal ganglia size and iron content in patients with Parkinson’s disease
  publication-title: J Neurol
  doi: 10.1007/s00415-005-0914-9
– volume: 63
  start-page: 2271
  year: 1998
  ident: 10.1016/j.nurt.2007.05.006_bib112
  article-title: Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis
  publication-title: Life Sci
  doi: 10.1016/S0024-3205(98)00512-8
– volume: 17
  start-page: 127
  year: 1988
  ident: 10.1016/j.nurt.2007.05.006_bib118
  article-title: Inhibition of allergic encephalomyelitis by the iron chelating agent desferrioxamine: differential effect depending on type of sensitizing encephalitogen
  publication-title: J Neuroimmunol
  doi: 10.1016/0165-5728(88)90020-3
– volume: 59
  start-page: 318
  year: 1995
  ident: 10.1016/j.nurt.2007.05.006_bib142
  article-title: Hereditary haemochromatosis: a case of iron accumulation in the basal ganglia associated with a parkinsonian syndrome
  publication-title: J Neurol Neurosurg Psychiatry
  doi: 10.1136/jnnp.59.3.318
– volume: 111
  start-page: 61
  year: 1996
  ident: 10.1016/j.nurt.2007.05.006_bib45
  article-title: Method for image-based measurement of the reversible and irreversible contribution to the transverse-relaxation rate
  publication-title: J Magn Reson Imaging
– volume: 62
  start-page: 69
  year: 1995
  ident: 10.1016/j.nurt.2007.05.006_bib172
  article-title: Suppression of hyperacute and passively transferred experimental autoimmune encephalomyelitis by the antioxidant, butylated hydroxyanisole
  publication-title: J Neuroimmunol
  doi: 10.1016/0165-5728(95)00104-A
– volume: 54
  start-page: 486
  year: 1998
  ident: 10.1016/j.nurt.2007.05.006_bib61
  article-title: Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid
  publication-title: J Neurosci Res
  doi: 10.1002/(SICI)1097-4547(19981115)54:4<486::AID-JNR6>3.0.CO;2-I
– volume: 52
  start-page: 332
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib99
  article-title: T2-weighted MRI in Parkinson’s disease; substantia nigra pars compacta hypointensity correlates with the clinical scores
  publication-title: Neurology India
– volume: 32
  start-page: 799
  year: 1992
  ident: 10.1016/j.nurt.2007.05.006_bib168
  article-title: The oxidant stress hypothesis in idiopathic Parkinson’s: evidence supporting it
  publication-title: Ann Neurol
  doi: 10.1002/ana.410320616
– volume: 7
  start-page: 195
  year: 1986
  ident: 10.1016/j.nurt.2007.05.006_bib16
  article-title: Brain trace elements in Alzheimer’s disease
  publication-title: Neurotoxicology
– volume: 211
  start-page: 489
  year: 1999
  ident: 10.1016/j.nurt.2007.05.006_bib36
  article-title: T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: relation to iron content
  publication-title: Radiology
  doi: 10.1148/radiology.211.2.r99ma53489
– volume: 23
  start-page: 1
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib27
  article-title: Imaging iron stores in the brain using magnetic resonance imaging
  publication-title: Magn Reson Imaging
  doi: 10.1016/j.mri.2004.10.001
– start-page: 1012
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib55
  article-title: Iron metabolism and the IRE/IRP regulator system: an update
  publication-title: Ann NY Acad Sci
– volume: 45
  start-page: 1138
  year: 1995
  ident: 10.1016/j.nurt.2007.05.006_bib41
  article-title: Increased iron-related MRI contrast in the substantia nigra in Parkinson’s disease
  publication-title: Neurology
  doi: 10.1212/WNL.45.6.1138
– volume: 49
  start-page: 633
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib134
  article-title: Ceruloplasmin in neurodegenerative diseases
  publication-title: Brain Res Brain Res Rev
  doi: 10.1016/j.brainresrev.2005.03.003
– volume: 64
  start-page: A236
  issue: suppl 1
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib21
  article-title: Iron accumulation in the deep gray matter of patients with MS measured by magnetic field correlation
  publication-title: Neurology
– volume: 3
  start-page: 41
  year: 1958
  ident: 10.1016/j.nurt.2007.05.006_bib76
  article-title: The effect of age on the non-haemin iron in the human brain
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.1958.tb12607.x
– volume: 60
  start-page: 1685
  year: 2003
  ident: 10.1016/j.nurt.2007.05.006_bib23
  article-title: Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
  publication-title: Arch Neurol
  doi: 10.1001/archneur.60.12.1685
– volume: 235
  start-page: 11
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib96
  article-title: Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson’s disease?
  publication-title: Novartis Found Symp
  doi: 10.1002/0470868694.ch3
– volume: 11
  start-page: 15
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib113
  article-title: MRI T2 shortening (“black T2”) in multiple sclerosis: frequency, location, and clinical correlation
  publication-title: Neuroreport
  doi: 10.1097/00001756-200001170-00004
– volume: 46
  start-page: 865
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib25
  article-title: A multiple course trial of desferrioxamine in chronic progressive multiple sclerosis
  publication-title: Cell Mol Biol
– volume: 288
  start-page: 591
  year: 1992
  ident: 10.1016/j.nurt.2007.05.006_bib58
  article-title: Evidence that H- and L-chains have co-operative roles in the iron-uptake mechanism of human ferritin
  publication-title: J Biochem
  doi: 10.1042/bj2880591
– volume: 101
  start-page: 9843
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib59
  article-title: The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0403495101
– volume: 1012
  start-page: 224
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib89
  article-title: Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases
  publication-title: Ann NY Acad Sci
  doi: 10.1196/annals.1306.019
– volume: 62
  start-page: 621
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib126
  article-title: Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up
  publication-title: Arch Neurol
  doi: 10.1001/archneur.62.4.621
– volume: 406
  start-page: 189
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib182
  article-title: Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2006.07.020
– volume: 193
  start-page: 473
  year: 1994
  ident: 10.1016/j.nurt.2007.05.006_bib140
  article-title: Toluene abuse: physical basis for hypointensity of the basal ganglia on T2-weighted images
  publication-title: Radiology
  doi: 10.1148/radiology.193.2.7972765
– volume: 27
  start-page: 1230
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib127
  article-title: Brain MRI in neurodegeneration with brain iron accumulation with and without PANK2 mutations
  publication-title: AJNR Am J Neuroradiol
– volume: 21
  start-page: 118
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib37
  article-title: Correlation of R2 with total iron concentration in the brains of rhesus monkeys
  publication-title: J Magn Reson Imaging
  doi: 10.1002/jmri.20244
– volume: 49
  start-page: 279
  year: 2002
  ident: 10.1016/j.nurt.2007.05.006_bib70
  article-title: Brain iron homeostasis
  publication-title: Dan Med Bull
– volume: 22
  start-page: 334
  year: 2007
  ident: 10.1016/j.nurt.2007.05.006_bib50
  article-title: Assessment of brain iron and neuronal integrity in patients with Parkinson’s disease using novel MRI contrasts
  publication-title: Mov Disord
  doi: 10.1002/mds.21227
– volume: 77
  start-page: 1386
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib110
  article-title: Proinflammatory cytokines promote glial heme oxygenase-1 expression and mitochondrial iron deposition: implications for multiple sclerosis
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.2001.00354.x
– volume: 899
  start-page: 112
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib9
  article-title: Oxidative stress, mitochondrial respiration, and Parkinson’s disease
  publication-title: Ann NY Acad Sci
  doi: 10.1111/j.1749-6632.2000.tb06180.x
– volume: 91
  start-page: 9
  year: 2002
  ident: 10.1016/j.nurt.2007.05.006_bib67
  article-title: Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells
  publication-title: J Inorg Biochem
  doi: 10.1016/S0162-0134(02)00461-0
– volume: 760
  start-page: 298
  year: 1997
  ident: 10.1016/j.nurt.2007.05.006_bib109
  article-title: Iron deposits in multiple sclerosis and Alzheimer’s disease brains
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(97)00470-8
– volume: 21
  start-page: 4183
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib164
  article-title: Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.21-12-04183.2001
– volume: 11
  start-page: 15
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib106
  article-title: MRI T2 shortening (“black T2”) in multiple sclerosis: frequency, location, and clinical correlation
  publication-title: Neuroreport
  doi: 10.1097/00001756-200001170-00004
– volume: 25
  start-page: 1315
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib177
  article-title: The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human b-amyloid precursor protein transgenic mice
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2004.01.005
– volume: 9
  start-page: 47
  year: 1992
  ident: 10.1016/j.nurt.2007.05.006_bib156
  article-title: Dextran-coupled deferoxamine improves outcome in a murine model of head injury
  publication-title: J Neurotrauma
  doi: 10.1089/neu.1992.9.47
– volume: 9
  start-page: 177
  year: 1998
  ident: 10.1016/j.nurt.2007.05.006_bib86
  article-title: Transferrin C2, metal binding and Alzheimer’s disease
  publication-title: Neuroreport
  doi: 10.1097/00001756-199801260-00001
– volume: 61
  start-page: 506
  year: 1996
  ident: 10.1016/j.nurt.2007.05.006_bib131
  article-title: Hereditary caeruloplasmin deficiency: clinicopathological study of a patient
  publication-title: J Neurol Neurosurg Psychiatry
  doi: 10.1136/jnnp.61.5.506
– volume: 27
  start-page: 1453
  year: 1996
  ident: 10.1016/j.nurt.2007.05.006_bib152
  article-title: A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS)
  publication-title: Stroke
  doi: 10.1161/01.STR.27.9.1453
– volume: 287
  start-page: 509
  year: 1992
  ident: 10.1016/j.nurt.2007.05.006_bib15
  article-title: Iron and aluminum in relation to brain ferritin in normal individuals and Alzheimer’s-disease and chronic renal-dialysis patients
  publication-title: Biochem J
  doi: 10.1042/bj2870509
– volume: 7
  start-page: 450
  year: 2007
  ident: 10.1016/j.nurt.2007.05.006_bib137
  article-title: Treatment of symptomatic heterozygous aceruloplasminemia with oral zinc sulphate
  publication-title: Brain Dev
  doi: 10.1016/j.braindev.2007.01.001
– volume: 70
  start-page: 133
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib101
  article-title: Potential sources of increased iron in the substantia nigra of parkinsonian patients
  publication-title: J Neural Transm Suppl
– volume: 234
  start-page: 17
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib107
  article-title: MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis
  publication-title: J Neurol Sci
  doi: 10.1016/j.jns.2005.02.009
– volume: 12
  start-page: 29
  year: 1992
  ident: 10.1016/j.nurt.2007.05.006_bib151
  article-title: Prevention of post-ischemic brain lipid conjugated diene production and neurological injury by hydroxyethyl starch-conjugated deferoxamine
  publication-title: Free Radic Biol Med
  doi: 10.1016/0891-5849(92)90055-L
– volume: 28
  start-page: 345
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib128
  article-title: A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome
  publication-title: Nat Genet
  doi: 10.1038/ng572
– volume: 52
  start-page: 1223
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib49
  article-title: T2rho-weighted contrast in MR images of the human brain
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.20284
– volume: 16
  start-page: 310
  year: 1989
  ident: 10.1016/j.nurt.2007.05.006_bib92
  article-title: Regional metal concentrations in Parkinson’s disease, other chronic neurological diseases, and control brains
  publication-title: Can J Neurol Sci
  doi: 10.1017/S0317167100029140
– volume: 210
  start-page: 759
  year: 1999
  ident: 10.1016/j.nurt.2007.05.006_bib33
  article-title: MR imaging of human brain at 3.0 T: preliminary report on transverse relaxation rates and relation to estimated iron content
  publication-title: Radiology
  doi: 10.1148/radiology.210.3.r99fe41759
– volume: 37
  start-page: 872
  year: 1997
  ident: 10.1016/j.nurt.2007.05.006_bib48
  article-title: An MRI method for measuring T2 in the presence of static and RF magnetic field inhomogeneities
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.1910370611
– volume: 20
  start-page: 1278
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib98
  article-title: In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage
  publication-title: Mov Disord
  doi: 10.1002/mds.20550
– volume: 119
  start-page: 48
  year: 2003
  ident: 10.1016/j.nurt.2007.05.006_bib87
  article-title: Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer’s disease and correlation with APOE
  publication-title: Am J Med Genet B Neuropsychiatr Genet
  doi: 10.1002/ajmg.b.10069
– volume: 1012
  start-page: 94
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib102
  article-title: Nutritional iron deprivation attenuates kainate-induced neurotoxicity in rats: implications for involvement of iron in neurodegeneration
  publication-title: Ann NY Acad Sci
  doi: 10.1196/annals.1306.008
– volume: 96
  start-page: 10812
  year: 1999
  ident: 10.1016/j.nurt.2007.05.006_bib133
  article-title: Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.96.19.10812
– volume: 47
  start-page: S161
  issue: suppl 3
  year: 1996
  ident: 10.1016/j.nurt.2007.05.006_bib8
  article-title: Oxidative stress and the pathogenesis of Parkinson’s disease
  publication-title: Neurology
– volume: 27
  start-page: 595
  year: 1990
  ident: 10.1016/j.nurt.2007.05.006_bib71
  article-title: Cellular distribution of transferrin, ferritin and iron in normal and aged human brains
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.490270421
– volume: 60
  start-page: 1679
  year: 2003
  ident: 10.1016/j.nurt.2007.05.006_bib163
  article-title: Idebenone treatment in Friedreich’s ataxia
  publication-title: Neurology
  doi: 10.1212/01.WNL.0000068549.52812.0F
– volume: 352
  start-page: 2379
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib165
  article-title: Vitamin E and donepezil for the treatment of mild cognitive impairment
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa050151
– volume: 28
  start-page: 350
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib62
  article-title: Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease
  publication-title: Nat Genet
  doi: 10.1038/ng571
– volume: 28
  start-page: 414
  year: 2007
  ident: 10.1016/j.nurt.2007.05.006_bib80
  article-title: Brain ferritin iron may influence age- and gender-related risks of neurodegeneration
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2006.02.005
– volume: 32
  start-page: S137
  year: 1992
  ident: 10.1016/j.nurt.2007.05.006_bib148
  article-title: Novel inhibitors of iron-dependent lipid peroxidation for neurodegenerative disorders
  publication-title: Ann Neurol
  doi: 10.1002/ana.410320724
– volume: 337
  start-page: 1304
  year: 1991
  ident: 10.1016/j.nurt.2007.05.006_bib24
  article-title: Intramuscular desferrioxamine in patients with Alzheimer’s disease
  publication-title: Lancet
  doi: 10.1016/0140-6736(91)92978-B
– volume: 7
  start-page: 266
  year: 1997
  ident: 10.1016/j.nurt.2007.05.006_bib44
  article-title: Theory and application of static field inhomogeneity effects in gradient-echo imaging
  publication-title: J Magn Reson Imaging
  doi: 10.1002/jmri.1880070203
– volume: 15
  start-page: 29
  year: 1997
  ident: 10.1016/j.nurt.2007.05.006_bib79
  article-title: MR evaluation of age-related increase of brain iron in young adult and older normal males
  publication-title: Magn Reson Imaging
  doi: 10.1016/S0730-725X(96)00234-2
– volume: 78
  start-page: 1073
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib167
  article-title: Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.2001.00490.x
– volume: 21
  start-page: 226
  issue: suppl 1
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib85
  article-title: β-Amyloid helps to protect neurons from oxidative stress
  publication-title: Neurobiol Aging
  doi: 10.1016/S0197-4580(00)83347-3
– volume: 64
  start-page: 280
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib122
  article-title: Hereditary ferritinopathy: a novel mutation, its cellular pathology, and pathogenetic insights
  publication-title: J Neuropathol Exp Neurol
  doi: 10.1093/jnen/64.4.280
– volume: 207
  start-page: 99
  year: 2003
  ident: 10.1016/j.nurt.2007.05.006_bib26
  article-title: Magnetic resonance imaging of brain iron
  publication-title: J Neurol Sci
  doi: 10.1016/S0022-510X(02)00431-8
– volume: 146
  start-page: 1041
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib179
  article-title: The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy
  publication-title: Br J Pharmacol
  doi: 10.1038/sj.bjp.0706416
– volume: 12
  start-page: 437
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib114
  article-title: Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis
  publication-title: Mult Scler
  doi: 10.1191/135248506ms1301oa
– volume: 37
  start-page: 461
  year: 1994
  ident: 10.1016/j.nurt.2007.05.006_bib57
  article-title: Isoforms of ferritin have a specific cellular distribution in the brain
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.490370405
– volume: 60
  start-page: 1735
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib54
  article-title: The physiopathological significance of ceruloplasmin
  publication-title: Biochem Pharmacol
  doi: 10.1016/S0006-2952(00)00399-3
– volume: 46
  start-page: 123
  year: 1999
  ident: 10.1016/j.nurt.2007.05.006_bib125
  article-title: Increased iron in the dentate nucleus of patients with Friedrich’s ataxia
  publication-title: Ann Neurol
  doi: 10.1002/1531-8249(199907)46:1<123::AID-ANA19>3.0.CO;2-H
– volume: 341
  start-page: 1219
  year: 1987
  ident: 10.1016/j.nurt.2007.05.006_bib5
  article-title: Increased nigral iron content in post-mortem parkinsonian brain
  publication-title: Lancet
  doi: 10.1016/S0140-6736(87)91361-4
– volume: 51
  start-page: 67
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib47
  article-title: Determination of transverse relaxation rate for estimating iron deposits in central nervous system
  publication-title: Neurosci Res
  doi: 10.1016/j.neures.2004.09.006
– volume: 11
  start-page: 2635
  year: 2002
  ident: 10.1016/j.nurt.2007.05.006_bib124
  article-title: A non-essential function for yeast frataxin in iron-sulfur cluster assembly
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/11.21.2635
– year: 2007
  ident: 10.1016/j.nurt.2007.05.006_bib116
  article-title: Deep gray matter “black T2” on 3 tesla magnetic resonance image correlates with disability in multiple sclerosis
  publication-title: Mult Scler
  doi: 10.1177/1352458507076411
– volume: 81
  start-page: 29
  year: 2007
  ident: 10.1016/j.nurt.2007.05.006_bib169
  article-title: Advances in the treatment of Parkinson’s disease
  publication-title: Prog Neurobiol
  doi: 10.1016/j.pneurobio.2006.11.009
– volume: 35
  start-page: 56
  year: 1996
  ident: 10.1016/j.nurt.2007.05.006_bib28
  article-title: The relation between brain iron and NMR relaxation times: an in vitro study
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.1910350108
– volume: 134
  start-page: 10
  issue: suppl
  year: 1995
  ident: 10.1016/j.nurt.2007.05.006_bib35
  article-title: Imaging of brain iron by magnetic resonance: T2 relaxation at different field strengths
  publication-title: J Neurol Sci
  doi: 10.1016/0022-510X(95)00203-E
– volume: 155
  start-page: 103
  year: 1999
  ident: 10.1016/j.nurt.2007.05.006_bib68
  article-title: Inhibition of iron-dependent and ischemia-induced brain damage by the alpha-tocopherol analogue MDL74,722
  publication-title: Exp Neurol
  doi: 10.1006/exnr.1998.6968
– volume: 123
  start-page: 2423
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib38
  article-title: Brain iron deposition in Parkinson’s disease imaged using the PRIME magnetic resonance sequence
  publication-title: Brain
  doi: 10.1093/brain/123.12.2423
– volume: 31
  start-page: 327
  year: 1992
  ident: 10.1016/j.nurt.2007.05.006_bib13
  article-title: Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer’s disease
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.490310214
– volume: 4
  start-page: 263
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib121
  article-title: Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention
  publication-title: Drug Saf
  doi: 10.2165/00002018-200022040-00002
– volume: 3
  start-page: 54
  year: 2007
  ident: 10.1016/j.nurt.2007.05.006_bib138
  article-title: Superficial siderosis: a case report and review of the literature
  publication-title: Nat Clin Pract Neurol
  doi: 10.1038/ncpneuro0356
– volume: 39
  start-page: 1009
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib69
  article-title: A transient treatment of hippocampal neurons with alpha-tocopherol induces a long-lasting protection against oxidative damage via a genomic action
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2005.05.021
– volume: 95
  start-page: 79
  year: 2005
  ident: 10.1016/j.nurt.2007.05.006_bib181
  article-title: Novel multifunctional neuroprotective iron chelator–monoamine oxidase inhibitor drugs for neurodegenerative diseases
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2005.03341.x
– volume: 29
  start-page: 1256
  year: 1998
  ident: 10.1016/j.nurt.2007.05.006_bib153
  article-title: High-dose tirilazad for acute stroke (RANTTAS II)
  publication-title: Stroke
  doi: 10.1161/str.29.6.1256/a
– volume: 15
  start-page: 572
  year: 2003
  ident: 10.1016/j.nurt.2007.05.006_bib129
  article-title: Unraveling the Hallervorden-Spatz syndrome: pantothenate kinase-associated neurodegeneration is the name
  publication-title: Curr Opin Pediatr
  doi: 10.1097/00008480-200312000-00005
– volume: 61
  start-page: 1171
  year: 1993
  ident: 10.1016/j.nurt.2007.05.006_bib84
  article-title: Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of β-amyloid peptide
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.1993.tb03639.x
– volume: 55
  start-page: 16
  year: 1990
  ident: 10.1016/j.nurt.2007.05.006_bib97
  article-title: Decreased ferritin levels in brain in Parkinson’s disease
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.1990.tb08814.x
– volume: 56
  start-page: 1441
  year: 1991
  ident: 10.1016/j.nurt.2007.05.006_bib103
  article-title: The iron chelator desferrioxamine (desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.1991.tb11444.x
– volume: 74
  start-page: 407
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib34
  article-title: T(2) relaxation rate of basal ganglia and cortex in patients with beta-thalassaemia major
  publication-title: Br J Radiol
  doi: 10.1259/bjr.74.881.740407
– volume: 104
  start-page: 469
  year: 1997
  ident: 10.1016/j.nurt.2007.05.006_bib104
  article-title: Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice
  publication-title: J Neural Transm
  doi: 10.1007/BF01277665
– volume: 41
  start-page: 404
  year: 1997
  ident: 10.1016/j.nurt.2007.05.006_bib135
  article-title: Use of desferrioxamine in the treatment of aceruloplasminemia
  publication-title: Ann Neurol
  doi: 10.1002/ana.410410318
– volume: 89
  start-page: 519
  year: 1998
  ident: 10.1016/j.nurt.2007.05.006_bib157
  article-title: A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury
  publication-title: J Neurosurg
  doi: 10.3171/jns.1998.89.4.0519
– volume: 39
  start-page: 103
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib66
  article-title: Antioxidant responses of cortex neurons to iron loading
  publication-title: Biol Res
  doi: 10.4067/S0716-97602006000100012
– volume: 961
  start-page: 139
  year: 2003
  ident: 10.1016/j.nurt.2007.05.006_bib178
  article-title: A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated tau of Alzheimer’s disease
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(02)03893-3
– volume: 73
  start-page: 91
  year: 2002
  ident: 10.1016/j.nurt.2007.05.006_bib3
  article-title: Palatal tremor and cognitive decline in neuroferritinopathy
  publication-title: J Neurol Neurosurg Psychiatry
  doi: 10.1136/jnnp.73.1.91
– volume: 336
  start-page: 1216
  year: 1997
  ident: 10.1016/j.nurt.2007.05.006_bib166
  article-title: A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199704243361704
– volume: 149
  start-page: 357
  year: 1987
  ident: 10.1016/j.nurt.2007.05.006_bib18
  article-title: Reduced signal intensity on MR Images of thalamus and putamen in multiple sclerosis: increased iron content?
  publication-title: AJR Am J Roentgenol
  doi: 10.2214/ajr.149.2.357
– volume: 17
  start-page: 16
  issue: suppl 1
  year: 2007
  ident: 10.1016/j.nurt.2007.05.006_bib108
  article-title: T1- and T2-based MRI measures of diffuse gray matter and white matter damage in patients with multiple sclerosis
  publication-title: J Neuroimaging
– volume: 136
  start-page: 6
  year: 1991
  ident: 10.1016/j.nurt.2007.05.006_bib7
  article-title: Oxidative stress as a cause of Parkinson’s disease
  publication-title: Acta Neurol Scand Suppl
  doi: 10.1111/j.1600-0404.1991.tb05013.x
– volume: 297
  start-page: 842
  year: 2007
  ident: 10.1016/j.nurt.2007.05.006_bib176
  article-title: Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
  publication-title: JAMA
  doi: 10.1001/jama.297.8.842
– volume: 55
  start-page: 1350
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib51
  article-title: Magnetic field correlation imaging
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.20907
– volume: 32
  start-page: 335
  year: 1994
  ident: 10.1016/j.nurt.2007.05.006_bib40
  article-title: Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.1910320309
– volume: 28
  start-page: 1431
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib149
  article-title: Desmethyl tirilazad improves neurologic function after hypoxic-ischemic brain injury in piglets
  publication-title: Crit Care Med
  doi: 10.1097/00003246-200005000-00029
– volume: 30
  start-page: 447
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib83
  article-title: Redox-active iron mediates amyloid-β toxicity
  publication-title: Free Radical Biol Med
  doi: 10.1016/S0891-5849(00)00494-9
– volume: 9
  start-page: 372
  year: 2003
  ident: 10.1016/j.nurt.2007.05.006_bib111
  article-title: Heme oxygenase-1 in SJL mice with experimental allergic encephalomyelitis
  publication-title: Multiple Sclerosis
  doi: 10.1191/1352458503ms928oa
– volume: 49
  start-page: 711
  year: 1992
  ident: 10.1016/j.nurt.2007.05.006_bib2
  article-title: Biological significance of iron-related magnetic resonance imaging changes in the brain
  publication-title: Arch Neurol
  doi: 10.1001/archneur.1992.00530310053012
– volume: 65
  start-page: 710
  year: 1995
  ident: 10.1016/j.nurt.2007.05.006_bib12
  article-title: Transferrin and iron in normal, Alzheimer’s disease, and Parkinson’s disease brain regions
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.1995.65020710.x
– volume: 1012
  start-page: 179
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib17
  article-title: Oxidative stress and redox-active iron in Alzheimer’s disease
  publication-title: Ann NY Acad Sci
  doi: 10.1196/annals.1306.015
– volume: 38
  start-page: 110
  year: 1992
  ident: 10.1016/j.nurt.2007.05.006_bib150
  article-title: Use of allopurinol and deferoxamine in cellular protection during ischemia
  publication-title: Surg Neurol
  doi: 10.1016/0090-3019(92)90087-4
– volume: 168
  start-page: 203
  year: 1988
  ident: 10.1016/j.nurt.2007.05.006_bib147
  article-title: Iron accumulation in the basal ganglia following severe ischemic-anoxic insults in children
  publication-title: Radiology
  doi: 10.1148/radiology.168.1.3380958
– volume: 28
  start-page: 258
  year: 2007
  ident: 10.1016/j.nurt.2007.05.006_bib81
  article-title: Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2005.12.010
– volume: 6
  start-page: 222
  year: 1996
  ident: 10.1016/j.nurt.2007.05.006_bib146
  article-title: Magnetic resonance imaging of corticobasal degeneration
  publication-title: J Neuroimaging
  doi: 10.1111/jon199664222
– volume: 181
  start-page: 715
  year: 1991
  ident: 10.1016/j.nurt.2007.05.006_bib78
  article-title: Deep gray matter hypointensity patterns with aging in healthy adults: MR imaging at 1.5T
  publication-title: Radiology
  doi: 10.1148/radiology.181.3.1947087
– volume: 21
  start-page: 1299
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib6
  article-title: Iron metabolism in Parkinsonian syndromes
  publication-title: Mov Disord
  doi: 10.1002/mds.21020
– volume: 56
  start-page: 1200
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib145
  article-title: FLAIR MRI of striatonigral degeneration
  publication-title: Neurology
  doi: 10.1212/WNL.56.9.1200
– volume: 61
  start-page: 311
  year: 2003
  ident: 10.1016/j.nurt.2007.05.006_bib95
  article-title: Iron and Parkinson’s disease: Chelators to the rescue?
  publication-title: Nutr Rev
  doi: 10.1301/nr.2003.sept.311-313
– volume: 96
  start-page: 1159
  year: 1995
  ident: 10.1016/j.nurt.2007.05.006_bib159
  article-title: Neurovascular dysfunction in diabetic rats
  publication-title: J Clin Invest
  doi: 10.1172/JCI118104
– volume: 126
  start-page: 47
  issue: suppl
  year: 1989
  ident: 10.1016/j.nurt.2007.05.006_bib94
  article-title: Is Parkinson’s disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration
  publication-title: Acta Neurol Scand
  doi: 10.1111/j.1600-0404.1989.tb01782.x
– volume: 67
  start-page: S8
  issue: suppl 2
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib60
  article-title: A proposed dual role of neuromelanin in the pathogenesis of Parkinson’s disease
  publication-title: Neurology
– volume: 8
  start-page: 1
  year: 1993
  ident: 10.1016/j.nurt.2007.05.006_bib10
  article-title: Parkinson’s disease and increased iron levels in substantia nigra zona compacta
  publication-title: Mov Disord
  doi: 10.1002/mds.870080102
– volume: 103
  start-page: 2799
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib162
  article-title: Iron chelation improves endothelial function in patients with coronary artery disease
  publication-title: Circulation
  doi: 10.1161/01.CIR.103.23.2799
– volume: 57
  start-page: 47
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib88
  article-title: In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.57.1.47
– volume: 1012
  start-page: 267
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib52
  article-title: Heredity causes of disturbed iron homeostasis in the central nervous system
  publication-title: Ann NY Acad Sci
  doi: 10.1196/annals.1306.022
– volume: 147
  start-page: 103
  year: 1986
  ident: 10.1016/j.nurt.2007.05.006_bib75
  article-title: MRI of brain iron
  publication-title: AJR Am J Roentgenol
  doi: 10.2214/ajr.147.1.103
– volume: 84
  start-page: 188
  year: 1998
  ident: 10.1016/j.nurt.2007.05.006_bib119
  article-title: Desferrioxamine suppresses experimental allergic encephalomyelitis induced by MBP in SJL mice
  publication-title: J Neuroimmunol
  doi: 10.1016/S0165-5728(97)00256-7
– volume: 59
  start-page: 62
  year: 2002
  ident: 10.1016/j.nurt.2007.05.006_bib19
  article-title: T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study
  publication-title: Arch Neurol
  doi: 10.1001/archneur.59.1.62
– volume: 173
  start-page: 5794
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib175
  article-title: Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis
  publication-title: J Immunol
  doi: 10.4049/jimmunol.173.9.5794
– volume: 64
  start-page: 648
  year: 1991
  ident: 10.1016/j.nurt.2007.05.006_bib154
  article-title: Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species
  publication-title: Lab Invest
– volume: 27
  start-page: 430
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib90
  article-title: Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss
  publication-title: AJNR Am J Neuroradiol
– volume: 46
  start-page: 254
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib180
  article-title: Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lesion in rats
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2003.09.005
– volume: 113
  start-page: 757
  year: 2006
  ident: 10.1016/j.nurt.2007.05.006_bib72
  article-title: Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability
  publication-title: J Neural Transm
  doi: 10.1007/s00702-006-0453-2
– volume: 65
  start-page: 899
  year: 1894
  ident: 10.1016/j.nurt.2007.05.006_bib64
  article-title: Oxidation of tartaric acid in presence of iron
  publication-title: J Chem Soc
  doi: 10.1039/CT8946500899
– volume: 25
  start-page: 63
  year: 2007
  ident: 10.1016/j.nurt.2007.05.006_bib46
  article-title: Echo-spacing optimization for the simultaneous measurement of reversible (R2’) and irreversible (R2) transverse relaxation rates
  publication-title: Magn Reson Imaging
  doi: 10.1016/j.mri.2006.09.008
– volume: 40
  start-page: 519
  year: 1998
  ident: 10.1016/j.nurt.2007.05.006_bib141
  article-title: MRI in chronic toluene abuse: low signal in the cerebral cortex on T2-weighted images
  publication-title: Neuroradiology
  doi: 10.1007/s002340050637
– volume: 32
  start-page: S16
  year: 1992
  ident: 10.1016/j.nurt.2007.05.006_bib1
  article-title: Iron and oxygen radicals in brain
  publication-title: Ann Neurol
  doi: 10.1002/ana.410320705
– volume: 17
  start-page: 213
  year: 1999
  ident: 10.1016/j.nurt.2007.05.006_bib31
  article-title: MRI evaluation of brain iron in earlier- and later-onset Parkinson’s disease and normal subjects
  publication-title: Magn Reson Imaging
  doi: 10.1016/S0730-725X(98)00155-6
– volume: 27
  start-page: 899
  year: 2003
  ident: 10.1016/j.nurt.2007.05.006_bib105
  article-title: Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson’s disease
  publication-title: Neuron
  doi: 10.1016/S0896-6273(03)00126-0
– volume: 130
  start-page: 110
  year: 2007
  ident: 10.1016/j.nurt.2007.05.006_bib123
  article-title: Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation
  publication-title: Brain
  doi: 10.1093/brain/awl319
– volume: 44
  start-page: 621
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib160
  article-title: Effects of an extracellular metal chelator on neurovascular function in diabetic rats
  publication-title: Diabetologia
  doi: 10.1007/s001250051669
– volume: 173
  start-page: 521
  year: 1989
  ident: 10.1016/j.nurt.2007.05.006_bib29
  article-title: T2 values in the human brain: comparison with quantitative assays of iron and ferritin
  publication-title: Radiology
  doi: 10.1148/radiology.173.2.2798884
– volume: 46
  start-page: 821
  year: 2000
  ident: 10.1016/j.nurt.2007.05.006_bib32
  article-title: MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer’s and Huntington’s disease
  publication-title: Cell Mol Biol
– volume: 19
  start-page: 339
  year: 1998
  ident: 10.1016/j.nurt.2007.05.006_bib14
  article-title: Imbalances of trace elements related to oxidative damage in Alzheimer’s disease brain
  publication-title: Neurotoxicology
– volume: 30
  start-page: 665
  year: 2001
  ident: 10.1016/j.nurt.2007.05.006_bib91
  article-title: Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer’s disease transgenic mice
  publication-title: Neuron
  doi: 10.1016/S0896-6273(01)00317-8
– volume: 36
  start-page: 851
  year: 2002
  ident: 10.1016/j.nurt.2007.05.006_bib136
  article-title: Aceruloplasminemia: new clinical, pathophysiological and therapeutic insights
  publication-title: J Hepatol
  doi: 10.1016/S0168-8278(02)00042-9
– volume: 50
  start-page: 35
  year: 1994
  ident: 10.1016/j.nurt.2007.05.006_bib170
  article-title: Oral administration of the oxidant scavenger N-acetyl-L-cysteine inhibits acute experimental autoimmune encephalomyelitis
  publication-title: J Neuroimmunol
  doi: 10.1016/0165-5728(94)90212-7
– volume: 29
  start-page: 459
  year: 1993
  ident: 10.1016/j.nurt.2007.05.006_bib43
  article-title: Field dependent transverse relaxation rate increase may be a specific measure of tissue iron stores
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.1910290406
– volume: 135
  start-page: 49
  year: 2004
  ident: 10.1016/j.nurt.2007.05.006_bib120
  article-title: The cardioprotector dexrazoxane augments therapeutic efficacy of mitoxantrone in experimental autoimmune encephalomyelitis
  publication-title: Clin Exp Immunol
  doi: 10.1111/j.1365-2249.2004.02344.x
– volume: 177
  start-page: 62
  year: 1997
  ident: 10.1016/j.nurt.2007.05.006_bib173
  article-title: Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites
  publication-title: Cell Immunol
  doi: 10.1006/cimm.1997.1091
SSID ssj0053398
Score 2.342566
SecondaryResourceType review_article
Snippet Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in...
Issue Title: Advances in Neuroimaging/Neuroethics Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin...
SourceID pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 371
SubjectTerms Alzheimer’s disease
Animals
Brain - metabolism
Brain - pathology
chelation
Free radicals
Humans
Iron
Iron - metabolism
Iron Metabolism Disorders - pathology
Magnetic Resonance Imaging
MRI
multiple sclerosis
neurodegeneration
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
Parkinson’s disease
Title Iron in Chronic Brain Disorders: Imaging and Neurotherapeutic Implications
URI https://www.clinicalkey.com/#!/content/1-s2.0-S1878747923006487
https://dx.doi.org/10.1016/j.nurt.2007.05.006
https://www.ncbi.nlm.nih.gov/pubmed/17599703
https://www.proquest.com/docview/1112256620
https://www.proquest.com/docview/70652915
https://pubmed.ncbi.nlm.nih.gov/PMC1963417
Volume 4
WOSCitedRecordID wos000249762800006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1878-7479
  dateEnd: 20231031
  omitProxy: false
  ssIdentifier: ssj0053398
  issn: 1878-7479
  databaseCode: 7X7
  dateStart: 20070101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Nursing & Allied Health Database
  customDbUrl:
  eissn: 1878-7479
  dateEnd: 20231031
  omitProxy: false
  ssIdentifier: ssj0053398
  issn: 1878-7479
  databaseCode: 7RV
  dateStart: 20070101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/nahs
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1878-7479
  dateEnd: 20231031
  omitProxy: false
  ssIdentifier: ssj0053398
  issn: 1878-7479
  databaseCode: BENPR
  dateStart: 20070101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Psychology Database
  customDbUrl:
  eissn: 1878-7479
  dateEnd: 20231031
  omitProxy: false
  ssIdentifier: ssj0053398
  issn: 1878-7479
  databaseCode: M2M
  dateStart: 20070101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/psychology
  providerName: ProQuest
– providerCode: PRVAVX
  databaseName: SpringerLINK Contemporary 1997-Present
  customDbUrl:
  eissn: 1878-7479
  dateEnd: 20231031
  omitProxy: false
  ssIdentifier: ssj0053398
  issn: 1878-7479
  databaseCode: RSV
  dateStart: 20040101
  isFulltext: true
  titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22
  providerName: Springer Nature
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Pb9MwFH5iHUJc-P0jMIYP3FBE7MR2zAUB2sSQWk0Fpt6s2E60InBH0_L385w4XQeiHLhYihxHid_z8xf7-fsAXjicZpyy4UQPNWlBa5qWxprUFNIqw2xuCtuJTcjJpJzN1GlccGtjWuUQE7tA7RY2rJG_wjGJricEy95c_EiDalTYXY0SGnuwH5jKihHsvzuanE6HWIxYplPDRZSSp_ivk8djM32Gl18vV5HEMCysiL9NTX9Cz98zKLempOPb__sxd-BWBKPkbe89d-Fa7e_BjXHcbr8PH0-WC0_mntieQpeYIChBXGTsbF-Tk--dyhGpvCMdNebWeS4y38pWfwBfjo8-v_-QRvGF1HJVrtIqL_JKVpaZWpRlbgXPTdYYVVHuhHCiqQS1jNXWFSWiqIw1wjHJHSIWKy32_EMY-YWvHwMx-BjHGsMdNQUClso2pUXfcco1jahdAnTod20jM3kQyPimhxS0rzrYKkhmSp1xjbZK4OWmzUXPy7Hz7nwwpx5OnGKM1Dht7GzFN60iHulxxj_bHQxW1zEitPrS5Ak831TjWA4bNJWvF-tWhy1npihP4FHvXpefJrlSGJwTkFccb3NDYAm_WuPn5x1beAixBZVPdr_UU7g5rFpn9ABGq-W6fgbX7c_VvF0ewp6cnoVyJruyPIwDDa_GbIzl9NPZL-DOM9k
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB5VBQEXypvQQn2AE4qIndhOkBBCQNWl7QqhgnpzYzsRWxVv2ey24k_xGxkn8XYLYjn1wDmeKI6_ediemQ_gqUU3YwvjK3qojjNa0TjXRsc6k6bQzKQ6My3ZhBwO84OD4uMK_Ay1MD6tMtjE1lDbsfFn5C9QJxF6QrDk9cn32LNG-dvVQKHRwWKn-nGGW7bm1eAdru8zxrbe77_djntWgdjwIp_GZZqlpSwN05XI89QInuqk1kVJuRXCiroU1DBWGZvlGB4krBaWSW7RFRtpEs8SgSb_Ctpx6lPI5KcvwfJj5NRy72JMlMa4s0r7Ip0un8zNJtO-ZaI_xhF_c4R_Brq_52suOMCttf_t192Cm32oTd50unEbVip3B67t9ckEd-HDYDJ2ZOSI6RoEE-3pMojt-5E2L8ngW8vhREpnSdv4c6FajYwWcvHvwedLmcl9WHVjVz0EovE1ltWaW6ozDMdKU-cGNcMWtq5FZSOgYZ2V6fuue_qPYxUS7I6Ux4YnBJUq4QqxEcHzucxJ13Vk6eg0wEeFelr0AAqd4lIpPpfqo60uivqn3EZAmertXaPOIRbB5vwxWip__VS6ajxrlL9QR6XhETzo4Hw-NcmLAl1PBPIC0OcDfA_0i0_c6GvbC907kIzKR8s_ahOub-_v7ardwXBnHW6E8_mEbsDqdDKrHsNVczodNZMnrUITOLxsNfgFSSSKVQ
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Nb9QwEB1VBVVc-KYECvUBTihq7MR2glQhRFmxlF31AFJvJrYTsQiyZbPbir_Gr-s4sbdbEMupB86Jozh5M29sz8wDeGaRZmxhXEUP1XFGKxrn2uhYZ9IUmplUZ6YTm5DjcX58XBxtwK9QC-PSKoNP7By1nRq3R76HNonQE4Ile7VPizg6GLw6-RE7BSl30hrkNHqIHFY_z3D51u4PD_BfP2ds8Pbjm3exVxiIDS_yeVymWVrK0jBdiTxPjeCpTmpdlJRbIayoS0ENY5WxWY6hQsJqYZnkFmnZSJM4xQh0_9dkxrlTTxixUWABjKI6HV6Mj9IYV1mpL9jpc8uaxWzu2ye6LR3xN1L8M-j9PXdzhQwHt_7nz3gbbvoQnLzubeYObFTNXdga-SSDe_B-OJs2ZNIQ0zcOJtrJaBDr-5S2L8nwe6ftRMrGkq4h6EoVG5ms5Ojfh09XMpMHsNlMm-ohEI2PsazW3FKdYZhWmjo3aDG2sHUtKhsBDf9cGd-P3cmCfFMh8e6rcjhxQqFSJVwhTiJ4sRxz0ncjWXt3GqCkQp0tMoNCslw7ii9H-Sisj67-OW4nIE55P9iqC7hFsLu8jB7MHUuVTTVdtModtLOC8gi2e2hfTE3yokBKikBeAv3yBtcb_fKVZvKl65HuiCWj8tH6l9qFLUS_-jAcHz6GG2HbPqE7sDmfLaoncN2czift7Gln2wQ-X7UVnANIJ5Ls
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Iron+in+chronic+brain+disorders%3A+Imaging+and+neurotherapeutic+implications&rft.jtitle=Neurotherapeutics&rft.au=Stankiewicz%2C+James&rft.au=Panter%2C+S.+Scott&rft.au=Neema%2C+Mohit&rft.au=Arora%2C+Ashish&rft.date=2007-07-01&rft.pub=Springer-Verlag&rft.issn=1933-7213&rft.eissn=1878-7479&rft.volume=4&rft.issue=3&rft.spage=371&rft.epage=386&rft_id=info:doi/10.1016%2Fj.nurt.2007.05.006&rft_id=info%3Apmid%2F17599703&rft.externalDocID=PMC1963417
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1878-7479&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1878-7479&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1878-7479&client=summon