Iron in Chronic Brain Disorders: Imaging and Neurotherapeutic Implications

Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer’s disease, Parkin...

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Veröffentlicht in:Neurotherapeutics Jg. 4; H. 3; S. 371 - 386
Hauptverfasser: Stankiewicz, James, Panter, S. Scott, Neema, Mohit, Arora, Ashish, Batt, Courtney E., Bakshi, Rohit
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 01.07.2007
Springer Nature B.V
Springer-Verlag
Schlagworte:
Alzheimer’s disease
Animals
Brain - metabolism
Brain - pathology
chelation
Free radicals
Humans
Iron
Iron - metabolism
Iron Metabolism Disorders - pathology
Magnetic Resonance Imaging
MRI
multiple sclerosis
neurodegeneration
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
Parkinson’s disease
Alzheimer’s disease
MRI
chelation
multiple sclerosis
neurodegeneration
Iron
Parkinson’s disease
ISSN:1878-7479, 1933-7213, 1878-7479
Online-Zugang:Volltext
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Zusammenfassung:Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. In vitro studies have demonstrated that excessive iron can lead to free radical production, which can promote neurotoxicity. However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood. It is not known whether excessive in vivo iron directly contributes to tissue damage or is solely an epiphenomenon. In this article, we focus on the imaging of brain iron and the underlying physiology and metabolism relating to iron deposition. We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development.
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ISSN:1878-7479
1933-7213
1878-7479
DOI:10.1016/j.nurt.2007.05.006