Validity of the Symbol Digit Modalities Test as a cognition performance outcome measure for multiple sclerosis

Cognitive and motor performance measures are commonly employed in multiple sclerosis (MS) research, particularly when the purpose is to determine the efficacy of treatment. The increasing focus of new therapies on slowing progression or reversing neurological disability makes the utilization of sens...

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Vydané v:	Multiple sclerosis Ročník 23; číslo 5; s. 721 - 733
Hlavní autori:	Benedict, Ralph Hb, DeLuca, John, Phillips, Glenn, LaRocca, Nicholas, Hudson, Lynn D, Rudick, Richard
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.04.2017
Predmet:	Cognition - physiology Cognition Disorders - physiopathology Female Humans Male Multiple Sclerosis - physiopathology Neuropsychological Tests Outcome Assessment (Health Care) Reproducibility of Results Task Performance and Analysis Multiple sclerosis performance outcome psychometric validity cognition Symbol Digit Modalities Test processing speed
ISSN:	1477-0970
On-line prístup:	Zistit podrobnosti o prístupe
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Abstract	Cognitive and motor performance measures are commonly employed in multiple sclerosis (MS) research, particularly when the purpose is to determine the efficacy of treatment. The increasing focus of new therapies on slowing progression or reversing neurological disability makes the utilization of sensitive, reproducible, and valid measures essential. Processing speed is a basic elemental cognitive function that likely influences downstream processes such as memory. The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) includes representatives from advocacy organizations, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Institute of Neurological Disorders and Stroke (NINDS), academic institutions, and industry partners along with persons living with MS. Among the MSOAC goals is acceptance and qualification by regulators of performance outcomes that are highly reliable and valid, practical, cost-effective, and meaningful to persons with MS. A critical step for these neuroperformance metrics is elucidation of clinically relevant benchmarks, well-defined degrees of disability, and gradients of change that are deemed clinically meaningful. This topical review provides an overview of research on one particular cognitive measure, the Symbol Digit Modalities Test (SDMT), recognized as being particularly sensitive to slowed processing of information that is commonly seen in MS. The research in MS clearly supports the reliability and validity of this test and recently has supported a responder definition of SDMT change approximating 4 points or 10% in magnitude.
AbstractList	Cognitive and motor performance measures are commonly employed in multiple sclerosis (MS) research, particularly when the purpose is to determine the efficacy of treatment. The increasing focus of new therapies on slowing progression or reversing neurological disability makes the utilization of sensitive, reproducible, and valid measures essential. Processing speed is a basic elemental cognitive function that likely influences downstream processes such as memory. The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) includes representatives from advocacy organizations, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Institute of Neurological Disorders and Stroke (NINDS), academic institutions, and industry partners along with persons living with MS. Among the MSOAC goals is acceptance and qualification by regulators of performance outcomes that are highly reliable and valid, practical, cost-effective, and meaningful to persons with MS. A critical step for these neuroperformance metrics is elucidation of clinically relevant benchmarks, well-defined degrees of disability, and gradients of change that are deemed clinically meaningful. This topical review provides an overview of research on one particular cognitive measure, the Symbol Digit Modalities Test (SDMT), recognized as being particularly sensitive to slowed processing of information that is commonly seen in MS. The research in MS clearly supports the reliability and validity of this test and recently has supported a responder definition of SDMT change approximating 4 points or 10% in magnitude.
Author	LaRocca, Nicholas Benedict, Ralph Hb Hudson, Lynn D Phillips, Glenn DeLuca, John Rudick, Richard
AuthorAffiliation	Multiple Sclerosis Outcome Assessments Consortium (MSOAC), Critical Path Institute, Tucson, AZ, USA
AuthorAffiliation_xml	– name: Multiple Sclerosis Outcome Assessments Consortium (MSOAC), Critical Path Institute, Tucson, AZ, USA
Author_xml	– sequence: 1 givenname: Ralph Hb surname: Benedict fullname: Benedict, Ralph Hb organization: Department of Neurology and Buffalo General Medical Center, University at Buffalo, Buffalo, NY, USA – sequence: 2 givenname: John surname: DeLuca fullname: DeLuca, John organization: Kessler Foundation, West Orange, NJ, USA; Rutgers New Jersey Medical School, Newark, NJ, USA – sequence: 3 givenname: Glenn surname: Phillips fullname: Phillips, Glenn organization: Biogen, Cambridge, MA, USA – sequence: 4 givenname: Nicholas surname: LaRocca fullname: LaRocca, Nicholas organization: National Multiple Sclerosis Society, New York, NY, USA – sequence: 5 givenname: Lynn D surname: Hudson fullname: Hudson, Lynn D organization: Critical Path Institute, Tucson, AZ, USA – sequence: 6 givenname: Richard surname: Rudick fullname: Rudick, Richard organization: Biogen, Cambridge, MA, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28206827$$D View this record in MEDLINE/PubMed
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SubjectTerms	Cognition - physiology Cognition Disorders - physiopathology Female Humans Male Multiple Sclerosis - physiopathology Neuropsychological Tests Outcome Assessment (Health Care) Reproducibility of Results Task Performance and Analysis
Title	Validity of the Symbol Digit Modalities Test as a cognition performance outcome measure for multiple sclerosis
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