Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis

Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL). Meta-analyses of data for time domain OCT show RNFL thinning of 20·38 μm (95% CI 17·91–22·86, n=2063, p<0·0001)...

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Bibliographic Details
Published in:Lancet neurology Vol. 9; no. 9; pp. 921 - 932
Main Authors: Petzold, Axel, de Boer, Johannes F, Schippling, Sven, Vermersch, Patrik, Kardon, Randy, Green, Ari, Calabresi, Peter A, Polman, Chris
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.09.2010
Elsevier Limited
Subjects:
Aging
Algorithms
Data processing
Fluorescence
Humans
Meta-Analysis as Topic
Models, Biological
Multiple sclerosis
Multiple Sclerosis - diagnosis
Nerves
Neurodegeneration
Neurology
Optic neuritis
Retina
Retina - pathology
Retinal ganglion cells
Reviews
Segmentation
Structure-function relationships
Systematic review
Thinning
Tomography
Tomography, Optical Coherence - methods
ISSN:1474-4422, 1474-4465, 1474-4465
Online Access:Get full text
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Summary:Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL). Meta-analyses of data for time domain OCT show RNFL thinning of 20·38 μm (95% CI 17·91–22·86, n=2063, p<0·0001) after optic neuritis in MS, and of 7·08 μm (5·52–8·65, n=3154, p<0·0001) in MS without optic neuritis. The estimated RNFL thinning in patients with MS is greater than the extent expected in normal ageing, probably because of retrograde trans-synaptic degeneration and progressive loss of retinal ganglion cells, in addition to the more pronounced thinning caused by optic neuritis if present. RNFL thickness correlates with visual and neurological functioning as well as with paraclinical data. Developments that could improve understanding of the relation between structure and function in MS pathophysiology include spectral or Fourier domain OCT technology, polarisation-sensitive OCT, fluorescence labelling, structural assessment of action-potential propagation, and segmentation algorithms allowing quantitative assessment of retinal layers.
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ISSN:1474-4422
1474-4465
1474-4465
DOI:10.1016/S1474-4422(10)70168-X