Bayesian statistical methods for genetic association studies

Key Points p -values are commonly used as summaries of evidence for association between a genetic variant and phenotype, but they have an important limitation in that they are unable to quantify how confident one should be that a given SNP is truly associated with a phenotype. Bayesian methods provi...

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Vydáno v:	Nature reviews. Genetics Ročník 10; číslo 10; s. 681 - 690
Hlavní autoři:	Stephens, Matthew, Balding, David J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.10.2009 Nature Publishing Group
Témata:	Agriculture Animal Genetics and Genomics Bayes Theorem Bayesian analysis Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Gene Function Genetics Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Genomes Genotype & phenotype Human Genetics Humans Hypotheses Methods, theories and miscellaneous Polymorphism, Single Nucleotide - genetics Population genetics Probability review-article Single nucleotide polymorphisms Software Statistical methods United States United Kingdom United Kingdom > UK Statistical method Review Single nucleotide polymorphism
ISSN:	1471-0056, 1471-0064, 1471-0064
On-line přístup:	Získat plný text
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