Bone Healing Improvements Using Hyaluronic Acid and Hydroxyapatite/Beta-Tricalcium Phosphate in Combination: An Animal Study

The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially...

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Veröffentlicht in:BioMed research international Jg. 2016; H. 2016; S. 1 - 8
Hauptverfasser: Huang, Haw-Ming, Lin, Che-Tong, Tsai, Hsin-Yuan, Huang, Yu-Chih, Feng, Sheng-Wei, Lo, Yi-June, Chang, Yen-Lan, Fan, Kan-Hsin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016
John Wiley & Sons, Inc
Schlagworte:
Acids
Animals
Bone and Bones - diagnostic imaging
Bone and Bones - pathology
Bone and Bones - surgery
Bone Diseases - therapy
Bone Regeneration
Bone Substitutes - chemistry
Bones
Calcium phosphate
Cell adhesion & migration
Composite materials
Density
Dentistry
Disease Models, Animal
Efficiency
Hospitals
Hyaluronic acid
Hydroxyapatite
Hydroxyapatites - chemistry
Osteogenesis
Particle size
Physical properties
Powders
Rabbits
Sinuses
Skull - pathology
Studies
Tissue engineering
Transmission Control Protocol/Internet Protocol (Computer network protocol)
Transplants & implants
Viscoelasticity
X-Ray Microtomography
Taiwan
ISSN:2314-6133, 2314-6141, 2314-6141
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Zusammenfassung:The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA-βTCP composite. Six New Zealand White rabbits (3.0–3.6 kg) were used as test subjects. Four 6 mm defects were prepared in the parietal bone. The defects were filled with the HLA/HA-βTCP composite as well as HA-βTCP particle alone. New bone formation was analyzed by micro-CT and histomorphometry. Our results indicated that even when the HA-βTCP particle numbers were reduced, the regenerative effect on bone remained when the HLA existed. The bone volume density (BV/TV ratio) of HLA/HA-βTCP samples was 1.7 times larger than that of the control sample at week 2. The new bone increasing ratio (NBIR) of HLA/HA-βTCP samples was 1.78 times higher than the control group at week 2. In conclusion, HA-βTCP powder with HLA contributed to bone healing in rabbit calvarial bone defects. The addition of HLA to bone grafts not only promoted osteoconduction but also improved handling characteristics in clinical situations.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Academic Editor: Ren-Yeong Huang
ISSN:2314-6133
2314-6141
2314-6141
DOI:10.1155/2016/8301624