Bone Healing Improvements Using Hyaluronic Acid and Hydroxyapatite/Beta-Tricalcium Phosphate in Combination: An Animal Study
The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially...
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| Vydáno v: | BioMed research international Ročník 2016; číslo 2016; s. 1 - 8 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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Cairo, Egypt
Hindawi Publishing Corporation
01.01.2016
John Wiley & Sons, Inc |
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| ISSN: | 2314-6133, 2314-6141, 2314-6141 |
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| Abstract | The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA-βTCP composite. Six New Zealand White rabbits (3.0–3.6 kg) were used as test subjects. Four 6 mm defects were prepared in the parietal bone. The defects were filled with the HLA/HA-βTCP composite as well as HA-βTCP particle alone. New bone formation was analyzed by micro-CT and histomorphometry. Our results indicated that even when the HA-βTCP particle numbers were reduced, the regenerative effect on bone remained when the HLA existed. The bone volume density (BV/TV ratio) of HLA/HA-βTCP samples was 1.7 times larger than that of the control sample at week 2. The new bone increasing ratio (NBIR) of HLA/HA-βTCP samples was 1.78 times higher than the control group at week 2. In conclusion, HA-βTCP powder with HLA contributed to bone healing in rabbit calvarial bone defects. The addition of HLA to bone grafts not only promoted osteoconduction but also improved handling characteristics in clinical situations. |
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| AbstractList | The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA-βTCP composite. Six New Zealand White rabbits (3.0-3.6 kg) were used as test subjects. Four 6 mm defects were prepared in the parietal bone. The defects were filled with the HLA/HA-βTCP composite as well as HA-βTCP particle alone. New bone formation was analyzed by micro-CT and histomorphometry. Our results indicated that even when the HA-βTCP particle numbers were reduced, the regenerative effect on bone remained when the HLA existed. The bone volume density (BV/TV ratio) of HLA/HA-βTCP samples was 1.7 times larger than that of the control sample at week 2. The new bone increasing ratio (NBIR) of HLA/HA-βTCP samples was 1.78 times higher than the control group at week 2. In conclusion, HA-βTCP powder with HLA contributed to bone healing in rabbit calvarial bone defects. The addition of HLA to bone grafts not only promoted osteoconduction but also improved handling characteristics in clinical situations.The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA-βTCP composite. Six New Zealand White rabbits (3.0-3.6 kg) were used as test subjects. Four 6 mm defects were prepared in the parietal bone. The defects were filled with the HLA/HA-βTCP composite as well as HA-βTCP particle alone. New bone formation was analyzed by micro-CT and histomorphometry. Our results indicated that even when the HA-βTCP particle numbers were reduced, the regenerative effect on bone remained when the HLA existed. The bone volume density (BV/TV ratio) of HLA/HA-βTCP samples was 1.7 times larger than that of the control sample at week 2. The new bone increasing ratio (NBIR) of HLA/HA-βTCP samples was 1.78 times higher than the control group at week 2. In conclusion, HA-βTCP powder with HLA contributed to bone healing in rabbit calvarial bone defects. The addition of HLA to bone grafts not only promoted osteoconduction but also improved handling characteristics in clinical situations. The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA-βTCP composite. Six New Zealand White rabbits (3.0–3.6 kg) were used as test subjects. Four 6 mm defects were prepared in the parietal bone. The defects were filled with the HLA/HA-βTCP composite as well as HA-βTCP particle alone. New bone formation was analyzed by micro-CT and histomorphometry. Our results indicated that even when the HA-βTCP particle numbers were reduced, the regenerative effect on bone remained when the HLA existed. The bone volume density (BV/TV ratio) of HLA/HA-βTCP samples was 1.7 times larger than that of the control sample at week 2. The new bone increasing ratio (NBIR) of HLA/HA-βTCP samples was 1.78 times higher than the control group at week 2. In conclusion, HA-βTCP powder with HLA contributed to bone healing in rabbit calvarial bone defects. The addition of HLA to bone grafts not only promoted osteoconduction but also improved handling characteristics in clinical situations. The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA- β TCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/ β TCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA- β TCP composite. Six New Zealand White rabbits (3.0–3.6 kg) were used as test subjects. Four 6 mm defects were prepared in the parietal bone. The defects were filled with the HLA/HA- β TCP composite as well as HA- β TCP particle alone. New bone formation was analyzed by micro-CT and histomorphometry. Our results indicated that even when the HA- β TCP particle numbers were reduced, the regenerative effect on bone remained when the HLA existed. The bone volume density (BV/TV ratio) of HLA/HA- β TCP samples was 1.7 times larger than that of the control sample at week 2. The new bone increasing ratio (NBIR) of HLA/HA- β TCP samples was 1.78 times higher than the control group at week 2. In conclusion, HA- β TCP powder with HLA contributed to bone healing in rabbit calvarial bone defects. The addition of HLA to bone grafts not only promoted osteoconduction but also improved handling characteristics in clinical situations. The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA- beta TCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/ beta TCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA- beta TCP composite. Six New Zealand White rabbits (3.0-3.6 kg) were used as test subjects. Four 6 mm defects were prepared in the parietal bone. The defects were filled with the HLA/HA- beta TCP composite as well as HA- beta TCP particle alone. New bone formation was analyzed by micro-CT and histomorphometry. Our results indicated that even when the HA- beta TCP particle numbers were reduced, the regenerative effect on bone remained when the HLA existed. The bone volume density (BV/TV ratio) of HLA/HA- beta TCP samples was 1.7 times larger than that of the control sample at week 2. The new bone increasing ratio (NBIR) of HLA/HA- beta TCP samples was 1.78 times higher than the control group at week 2. In conclusion, HA- beta TCP powder with HLA contributed to bone healing in rabbit calvarial bone defects. The addition of HLA to bone grafts not only promoted osteoconduction but also improved handling characteristics in clinical situations. The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA- TCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/ TCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA- TCP composite. Six New Zealand White rabbits (3.0-3.6 kg) were used as test subjects. Four 6 mm defects were prepared in the parietal bone. The defects were filled with the HLA/HA- TCP composite as well as HA- TCP particle alone. New bone formation was analyzed by micro-CT and histomorphometry. Our results indicated that even when the HA- TCP particle numbers were reduced, the regenerative effect on bone remained when the HLA existed. The bone volume density (BV/TV ratio) of HLA/HA- TCP samples was 1.7 times larger than that of the control sample at week 2. The new bone increasing ratio (NBIR) of HLA/HA- TCP samples was 1.78 times higher than the control group at week 2. In conclusion, HA- TCP powder with HLA contributed to bone healing in rabbit calvarial bone defects. The addition of HLA to bone grafts not only promoted osteoconduction but also improved handling characteristics in clinical situations. |
| Audience | Academic |
| Author | Lin, Che-Tong Lo, Yi-June Chang, Yen-Lan Feng, Sheng-Wei Tsai, Hsin-Yuan Fan, Kan-Hsin Huang, Haw-Ming Huang, Yu-Chih |
| AuthorAffiliation | 6 Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan 4 School of Oral Hygiene, College of Oral Sciences, Taipei Medical University, Taipei, Taiwan 2 Dental Department, Mackey Memorial Hospital, Taipei, Taiwan 3 Dental Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan 5 Dental Department, En Chu Kong Hospital, New Taipei City, Taiwan 1 School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan |
| AuthorAffiliation_xml | – name: 5 Dental Department, En Chu Kong Hospital, New Taipei City, Taiwan – name: 6 Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan – name: 3 Dental Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan – name: 2 Dental Department, Mackey Memorial Hospital, Taipei, Taiwan – name: 4 School of Oral Hygiene, College of Oral Sciences, Taipei Medical University, Taipei, Taiwan – name: 1 School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan |
| Author_xml | – sequence: 1 fullname: Huang, Haw-Ming – sequence: 2 fullname: Lin, Che-Tong – sequence: 3 fullname: Tsai, Hsin-Yuan – sequence: 4 fullname: Huang, Yu-Chih – sequence: 5 fullname: Feng, Sheng-Wei – sequence: 6 fullname: Lo, Yi-June – sequence: 7 fullname: Chang, Yen-Lan – sequence: 8 fullname: Fan, Kan-Hsin |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28070520$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2016 Yen-Lan Chang et al. COPYRIGHT 2016 John Wiley & Sons, Inc. Copyright © 2016 Yen-Lan Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2016 Yen-Lan Chang et al. 2016 |
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| Title | Bone Healing Improvements Using Hyaluronic Acid and Hydroxyapatite/Beta-Tricalcium Phosphate in Combination: An Animal Study |
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