Prevalence studies of GB Virus-C infection using reverse transcriptase-polymerase chain reaction

Among the three recently described GB viruses (GBV‐A, GBV‐B, and GBV‐C), only GBV‐C has been linked to cryptogenic hepatitis in man. Because of the limited utility of currently available research tests to determine antibody response to GBV‐C proteins, the prevalence of GBV‐C RNA in human sera was st...

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Vydáno v:	Journal of medical virology Ročník 50; číslo 1; s. 97 - 103
Hlavní autoři:	Dawson, George J., Schlauder, George G., Pilot-Matias, Tami J., Thiele, Dwain, Leary, Thomas P., Murphy, Paul, Rosenblatt, Jon E., Simons, John N., Martinson, Francis E. A., Gutierrez, Robin A., Lentino, Joseph R., Pachucki, Constance, Muerhoff, A. Scott, Widell, Anders, Tegtmeier, Gary, Desai, Suresh, Mushahwar, Isa K.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Wiley Subscription Services, Inc., A Wiley Company 01.09.1996
Témata:	Basic Medicine Flaviviridae - genetics Flaviviridae - isolation & purification Flaviviridae - physiology GBV-C HCV hepatitis Hepatitis, Viral, Human - blood Hepatitis, Viral, Human - epidemiology Hepatitis, Viral, Human - virology Humans Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Microbiology in the Medical Area Mikrobiologi inom det medicinska området Polymerase Chain Reaction - methods RNA, Viral - blood Viremia Virus Latency
ISSN:	0146-6615, 1096-9071, 1096-9071
On-line přístup:	Získat plný text
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Shrnutí:	Among the three recently described GB viruses (GBV‐A, GBV‐B, and GBV‐C), only GBV‐C has been linked to cryptogenic hepatitis in man. Because of the limited utility of currently available research tests to determine antibody response to GBV‐C proteins, the prevalence of GBV‐C RNA in human sera was studied using reverse transcription‐polymerase chain reaction (RT‐PCR). The prevalence of GBV‐C is higher among volunteer blood donors with elevated serum alanine aminotransferase (ALT) levels (3.9%) than among volunteer blood donors with normal ALT levels (0.8%). Higher rates were also noted among commercial blood donors (12.9%) and intravenous drug users (16.0%). GBV‐C was frequently detected in residents of West Africa, where the prevalence was >10% in most age groups. Approximately 20% of patients diagnosed with either acute or chronic hepatitis C virus (HCV) were found to be positive for GBV‐C RNA. In addition, GBV‐C RNA sequences were detected in individuals diagnosed with non‐A‐E hepatitis, with clinical courses ranging from mild disease to fulminant hepatitis. Fourteen of sixteen subjects with or without clinically apparent hepatitis were positive for GBV‐C RNA more than 1 year after the initial positive result. © 1996 Wiley‐Liss, Inc.
Bibliografie:	ArticleID:JMV16 ark:/67375/WNG-R9LJ1PQM-S istex:DCD13E9B50E3F1B77B5A1884E142F6179AE0E5A1 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0146-6615 1096-9071 1096-9071
DOI:	10.1002/(SICI)1096-9071(199609)50:1<97::AID-JMV16>3.0.CO;2-V