Vascular neuropeptide Y contributes to atherosclerotic plaque progression and perivascular mast cell activation

Neuropeptide Y is an abundantly expressed neurotransmitter capable of modulating both immune and metabolic responses related to the development of atherosclerosis. NPY receptors are expressed by a number of vascular wall cell types, among which mast cells. However, the direct effects of NPY on ather...

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Bibliographic Details
Published in:	Atherosclerosis Vol. 235; no. 1; pp. 196 - 203
Main Authors:	Lagraauw, H. Maxime, Westra, Marijke M., Bot, Martine, Wezel, Anouk, van Santbrink, Peter J., Pasterkamp, Gerard, Biessen, Erik A.L., Kuiper, Johan, Bot, Ilze
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01.07.2014
Subjects:	Animals Apolipoproteins E - blood Atherosclerosis Atherosclerosis - blood Cardiovascular Disease Progression Gene Expression Profiling Gene Expression Regulation HEK293 Cells Humans Immunohistochemistry Inflammation - blood Interleukin-6 - blood Lentivirus Lentivirus - genetics Mast cell Mast Cells - cytology Mice Mice, Knockout Muscle, Smooth, Vascular - metabolism Nerve fiber Neuropeptide Y Neuropeptide Y - blood Plaque, Atherosclerotic - blood Plaque, Atherosclerotic - pathology Tryptases - blood Neuropeptide Y Mast cell Nerve fiber Lentivirus Atherosclerosis
ISSN:	0021-9150, 1879-1484, 1879-1484
Online Access:	Get full text
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