Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway

Neuroinflammation is a common feature of neurodegenerative disorders such as Alzheimer's disease (AD). Neuroinflammation is induced by dysregulated glial activation, and astrocytes, the most abundant glial cells, become reactive upon neuroinflammatory cytokines released from microglia and activ...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 120; no. 33; p. e2303809120
Main Authors:	Nakano-Kobayashi, Akiko, Canela, Andres, Yoshihara, Toru, Hagiwara, Masatoshi
Format:	Journal Article
Language:	English
Published:	United States 15.08.2023
Subjects:	Alzheimer Disease - metabolism Animals Astrocytes - metabolism Cognitive Dysfunction - metabolism Inflammation - metabolism Mice Microglia - metabolism Neuroinflammatory Diseases NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism Nrf2 neuroinflammation neurotoxic reactive astrocytes
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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