Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway

Neuroinflammation is a common feature of neurodegenerative disorders such as Alzheimer's disease (AD). Neuroinflammation is induced by dysregulated glial activation, and astrocytes, the most abundant glial cells, become reactive upon neuroinflammatory cytokines released from microglia and activ...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 120; H. 33; S. e2303809120
Hauptverfasser:	Nakano-Kobayashi, Akiko, Canela, Andres, Yoshihara, Toru, Hagiwara, Masatoshi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.08.2023
Schlagworte:	Alzheimer Disease - metabolism Animals Astrocytes - metabolism Cognitive Dysfunction - metabolism Inflammation - metabolism Mice Microglia - metabolism Neuroinflammatory Diseases NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism Nrf2 neuroinflammation neurotoxic reactive astrocytes
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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