Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

Fibroblasts are the most abundant “non-cancerous” cells in tumors. However, it remains largely unknown how these cancer-associated fibroblasts (CAFs) promote tumor growth and metastasis, driving chemotherapy resistance and poor clinical outcome. This review summarizes new findings on CAF signaling p...

Full description

Saved in:

Bibliographic Details
Published in:	Seminars in cancer biology Vol. 25; pp. 47 - 60
Main Authors:	Martinez-Outschoorn, Ubaldo E., Lisanti, Michael P., Sotgia, Federica
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.04.2014
Subjects:	Animals Autophagy Catabolism Cell Communication Energy Metabolism Energy Transfer Fibroblasts - metabolism Hematology, Oncology and Palliative Medicine Humans Neoplasms - metabolism Neoplasms - pathology Oxidative mitochondrial metabolism Oxidative Stress Senescence Signal Transduction Tumor Burden Tumor metabolism Tumor Microenvironment Warburg effect Oxidative stress Tumor metabolism Senescence Oxidative mitochondrial metabolism Catabolism Autophagy Warburg effect
ISSN:	1044-579X, 1096-3650, 1096-3650
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!