Tumor-infiltrating lymphocytes: apparently good for melanoma patients. But why?
Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical...
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| Vydáno v: | Cancer Immunology, Immunotherapy Ročník 60; číslo 8; s. 1153 - 1160 |
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| Hlavní autoři: | , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Berlin/Heidelberg
Springer-Verlag
01.08.2011
Springer Springer Nature B.V |
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| ISSN: | 0340-7004, 1432-0851, 1432-0851 |
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| Abstract | Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens. |
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| AbstractList | Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens. Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens. |
| Author | Cipponi, Arcadi van Baren, Nicolas Coulie, Pierre G. Wieers, Grégoire |
| Author_xml | – sequence: 1 givenname: Arcadi surname: Cipponi fullname: Cipponi, Arcadi organization: de Duve Institute, Université catholique de Louvain – sequence: 2 givenname: Grégoire surname: Wieers fullname: Wieers, Grégoire organization: de Duve Institute, Université catholique de Louvain, Ludwig Institute for Cancer Research, Brussels Branch – sequence: 3 givenname: Nicolas surname: van Baren fullname: van Baren, Nicolas organization: de Duve Institute, Université catholique de Louvain, Ludwig Institute for Cancer Research, Brussels Branch – sequence: 4 givenname: Pierre G. surname: Coulie fullname: Coulie, Pierre G. email: pierre.coulie@uclouvain.be organization: de Duve Institute, Université catholique de Louvain |
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| Keywords | PIVAC 10 Prognosis T lymphocyte Immunotherapy Melanoma Human Patient Tumor infiltrating lymphocyte Malignant tumor Treatment T-Lymphocyte Malignant melanoma Cancer |
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