Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE

The mediators that drive the progressive phase of multiple sclerosis remain undefined. Weiner and colleagues find that 15α-hydroxycholestene is expressed abundantly only during progressive multiple sclerosis and activates macrophages, microglia and astrocytes via poly(ADP-ribose) polymerase 1. Multi...

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Bibliographic Details
Published in:	Nature immunology Vol. 10; no. 9; pp. 958 - 964
Main Authors:	Farez, Mauricio F, Quintana, Francisco J, Gandhi, Roopali, Izquierdo, Guillermo, Lucas, Miguel, Weiner, Howard L
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.09.2009 Nature Publishing Group
Subjects:	Adult Aged Analysis Animals Autoimmune diseases Biomedical and Life Sciences Biomedicine Care and treatment Central nervous system Diagnosis Encephalomyelitis, Autoimmune, Experimental - immunology Female Humans Hydroxycholesterols - blood Immunology Infectious Diseases Male Mice Mice, Inbred NOD Middle Aged Multiple sclerosis Multiple Sclerosis, Chronic Progressive - immunology Physiology, Pathological Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases - physiology Risk factors Toll-Like Receptor 2 - immunology Toll-Like Receptor 2 - physiology
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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