Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity

A critical challenge lies in the development of the next‐generation neural interface, in mechanically tissue‐compatible fashion, that offer accurate, transient recording electrophysiological (EP) information and autonomous degradation after stable operation. Here, an ultrathin, lightweight, soft and...

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Veröffentlicht in:Advanced science Jg. 10; H. 14; S. e2300504 - n/a
Hauptverfasser: Wu, Mengge, Yao, Kuanming, Huang, Ningge, Li, Hu, Zhou, Jingkun, Shi, Rui, Li, Jiyu, Huang, Xingcan, Li, Jian, Jia, Huiling, Gao, Zhan, Wong, Tsz Hung, Li, Dengfeng, Hou, Sihui, Liu, Yiming, Zhang, Shiming, Song, Enming, Yu, Junsheng, Yu, Xinge
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Germany John Wiley & Sons, Inc 01.05.2023
John Wiley and Sons Inc
Wiley
Schlagworte:
Absorbable Implants
Animals
Biocompatibility
Biodegradable materials
bioresorbable materials
Brain - physiology
Delirium
Electrodes
Electrolytes
Electronics
Electrophysiological Phenomena
Heart surgery
Interfaces
Materials selection
multichannel electrophysiology mapping
neural interfaces
organic electrochemical transistor
Polylactic acid
Rats
Semiconductors
Signal to noise ratio
transient electronics
Transistors
Transplants & implants
neural interfaces
transient electronics
multichannel electrophysiology mapping
bioresorbable materials
organic electrochemical transistor
ISSN:2198-3844, 2198-3844
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Zusammenfassung:A critical challenge lies in the development of the next‐generation neural interface, in mechanically tissue‐compatible fashion, that offer accurate, transient recording electrophysiological (EP) information and autonomous degradation after stable operation. Here, an ultrathin, lightweight, soft and multichannel neural interface is presented based on organic‐electrochemical‐transistor‐(OECT)‐based network, with capabilities of continuous high‐fidelity mapping of neural signals and biosafety active degrading after performing functions. Such platform yields a high spatiotemporal resolution of 1.42 ms and 20 µm, with signal‐to‐noise ratio up to ≈37 dB. The implantable OECT arrays can well establish stable functional neural interfaces, designed as fully biodegradable electronic platforms in vivo. Demonstrated applications of such OECT implants include real‐time monitoring of electrical activities from the cortical surface of rats under various conditions (e.g., narcosis, epileptic seizure, and electric stimuli) and electrocorticography mapping from 100 channels. This technology offers general applicability in neural interfaces, with great potential utility in treatment/diagnosis of neurological disorders. The ultrasoft, multichannel, biodegradable OECT‐based neural interfaces are developed, which not only monitor the μ‐ECoG signals in high fidelity, but also autonomous degradation without any trigger events. Arrays with 100 channels, temporal/spatial resolution of 1.42 ms and 20 µm, and great signal‐to‐noise ratio of 37 dB, are achieved, demonstrating a facile and efficient tool for diagnostic purposes and neuroscience research.
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ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202300504