Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface

The vascular network of the brain is formed by the invasion of vascular sprouts from the pia mater toward the ventricles. Following angiogenesis of the primary vascular network, brain vessels experience a maturation process known as barriergenesis, in which the blood-brain barrier is formed. In this...

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Bibliographic Details
Published in:	The FEBS journal Vol. 276; no. 17; pp. 4622 - 4635
Main Authors:	Lee, Hye Shin, Han, Jiyeon, Bai, Hyun-Jeong, Kim, Kyu-Won
Format:	Journal Article
Language:	English
Published:	Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.09.2009 Blackwell Publishing Ltd
Subjects:	Angiogenesis angiopoietin-1 Animals astrocyte astrocytes Axons Axons - pathology Axons - physiology barriergenesis Biochemistry blood supply Blood vessels blood-brain barrier Blood-Brain Barrier - embryology Blood-Brain Barrier - growth & development Blood-Brain Barrier - physiology Brain Brain - blood supply Brain - embryology Brain - growth & development brain angiogenesis Cell Communication Cell Communication - physiology Cellular biology embryology endothelial cell growth & development homeostasis Humans Hypoxia Hypoxia - physiopathology macrophages Molecular biology myocytes Neovascularization, Pathologic Neovascularization, Physiologic Neurogenesis Neurogenesis - physiology neuron neurons Neurons - pathology Neurons - physiology neurotrophins neurovascular interface pathology pericyte perivascular macrophage physiology physiopathology Signal Transduction smooth muscle smooth muscle cell vascular endothelial growth factors
ISSN:	1742-464X, 1742-4658, 1742-4658
Online Access:	Get full text
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Summary:	The vascular network of the brain is formed by the invasion of vascular sprouts from the pia mater toward the ventricles. Following angiogenesis of the primary vascular network, brain vessels experience a maturation process known as barriergenesis, in which the blood-brain barrier is formed. In this minireview, we discuss the processes of brain angiogenesis and barriergenesis, as well as the molecular and cellular mechanisms underlying brain vessel formation. At the molecular level, angiogenesis and barriergenesis occur via the coordinated action of oxygen-responsive molecules (e.g. hypoxia-inducible factor and Src-suppressed C kinase substrate/AKAP12) and soluble factors (e.g. vascular endothelial growth factor and angiopoietin-1), as well as axon guidance molecules and neurotrophic factors. At the cellular level, we focus on neurovascular cells, such as pericytes, astrocytes, vascular smooth muscle cells, neurons and brain macrophages. Each cell type plays a unique role, and works with other types to maintain environmental homeostasis and to respond to certain stimuli. Taken together, this minireview emphasizes the importance of the coordinated action of molecules and cells at the neurovascular interface, with regards to the regulation of angiogenesis and barriergenesis.
Bibliography:	http://dx.doi.org/10.1111/j.1742-4658.2009.07174.x SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Review-3
ISSN:	1742-464X 1742-4658 1742-4658
DOI:	10.1111/j.1742-4658.2009.07174.x