Optimizing megakaryocyte polyploidization by targeting multiple pathways of cytokinesis

BACKGROUND: Large‐scale in vitro production of platelets (PLTs) from cord blood stem cells is one goal of stem cell research. One step toward this goal will be to produce polyploid megakaryocytes capable of releasing high numbers of PLTs. Megakaryocyte polyploidization requires distinct cytoskeletal...

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Bibliographic Details
Published in:	Transfusion (Philadelphia, Pa.) Vol. 52; no. 11; pp. 2406 - 2413
Main Authors:	Avanzi, Mauro P., Chen, Amanda, He, Wu, Mitchell, W. Beau
Format:	Journal Article
Language:	English
Published:	Malden, USA Blackwell Publishing Inc 01.11.2012 Wiley Wiley Subscription Services, Inc
Subjects:	Actin Cytoskeleton - physiology Amides - pharmacology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Benzamides - pharmacology Biological and medical sciences Blood Platelets - cytology Blood Platelets - physiology Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Cells, Cultured Cytokinesis - drug effects Cytokinesis - physiology Enzyme Inhibitors - pharmacology Fetal Blood - cytology Humans Indoles - pharmacology Medical research Medical sciences Megakaryocytes - cytology Megakaryocytes - drug effects Megakaryocytes - physiology Microtubules - physiology Niacinamide - pharmacology Ploidies Polyploidy Pyridines - pharmacology Quinazolines - pharmacology Signal Transduction - drug effects Signal Transduction - physiology src-Family Kinases - antagonists & inhibitors Stem cells Sulfonamides - pharmacology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vitamin B Complex - pharmacology Megakaryocyte Multiple Transfusion Targeting Optimization
ISSN:	0041-1132, 1537-2995, 1537-2995
Online Access:	Get full text
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