Persister cancer cells: Iron addiction and vulnerability to ferroptosis

Ferroptosis is a unique type of non-apoptotic cell death resulting from the unrestrained occurrence of peroxidized phospholipids, which are subject to iron-mediated production of lethal oxygen radicals. This cell death modality has been detected across many organisms, including in mammals, where it...

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Vydáno v:	Molecular cell Ročník 82; číslo 4; s. 728
Hlavní autoři:	Rodriguez, Raphaël, Schreiber, Stuart L, Conrad, Marcus
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 17.02.2022
Témata:	Animals Antineoplastic Agents - therapeutic use Cell Differentiation Ferroptosis - drug effects Homeostasis Humans Iron - metabolism Lipid Peroxidation - drug effects Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Reactive Oxygen Species - metabolism Signal Transduction
ISSN:	1097-4164, 1097-4164
On-line přístup:	Zjistit podrobnosti o přístupu
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