In utero pyrethroid pesticide exposure in relation to autism spectrum disorder (ASD) and other neurodevelopmental outcomes at 3 years in the MARBLES longitudinal cohort

We assessed the relationships between prenatal pyrethroid pesticide exposure and autism spectrum disorders (ASD) or non-typical development (non-TD) at 3 years. Participants were mother-child pairs (n = 201) in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) cohort. Because famil...

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Veröffentlicht in:Environmental research Jg. 194; S. 110495
Hauptverfasser: Barkoski, Jacqueline M., Philippat, Claire, Tancredi, Daniel, Schmidt, Rebecca J., Ozonoff, Sally, Barr, Dana Boyd, Elms, William, Bennett, Deborah H., Hertz-Picciotto, Irva
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier Inc 01.03.2021
Elsevier
Schlagworte:
Autism
Autism Spectrum Disorder - chemically induced
Autism Spectrum Disorder - epidemiology
Calcium Carbonate
Child
children
chlorpyrifos
Cohort Studies
confidence interval
Female
home ownership
Humans
Life Sciences
MARBLES
metabolites
Neurodevelopment
Pesticide
Pesticides - toxicity
Pregnancy
pyrethrins
Pyrethrins - toxicity
Pyrethroid
regression analysis
relative risk
Santé publique et épidémiologie
specific gravity
urine
Pyrethroid
Pregnancy
Neurodevelopment
Autism
MARBLES
Pesticide
ISSN:0013-9351, 1096-0953, 1096-0953
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Zusammenfassung:We assessed the relationships between prenatal pyrethroid pesticide exposure and autism spectrum disorders (ASD) or non-typical development (non-TD) at 3 years. Participants were mother-child pairs (n = 201) in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) cohort. Because familial recurrence risk is high, MARBLES enrolls pregnant women with a family history of ASD. Children from these pregnancies were clinically assessed at 3 years of age and classified into 3 outcome categories: ASD, typically developing (TD), or non-TD (neither TD or ASD). Repeated maternal second and third trimester urine samples were analyzed for pyrethroid metabolite 3-phenoxybenzoic acid (3-PBA). Multinomial logistic regression was used to obtain relative risk ratios (RRR) linking 3-PBA concentrations averaged across each trimester and over pregnancy with child's outcome: ASD or non-TD vs. TD. Models were adjusted for specific gravity, maternal pre-pregnancy BMI, prenatal vitamin use, birth year, home-ownership, and pregnancy concentrations of TCPy (3,5,6-trichloro-2-pyridinol, a metabolite of chlorpyrifos). The median specific gravity corrected 3-PBA concentration of all samples was 1.46 ng/mL. Greater second trimester 3-PBA concentrations were associated with a relative risk ratio (RRR) for ASD of (RRR: 1.50 (95% CI 0.89 to 2.51), p = 0.12). There were no differences between non-TD and TD. This study found no evidence for differences in 3-PBA comparing non-TD with TD. A modestly elevated RRR was found comparing second trimester urinary 3-PBA concentrations for ASD versus TD; however, the confidence interval was wide and hence, these findings cannot be considered definitive. •First study of pregnancy pyrethroid pesticide biomarker and risk of ASD at 3-years.•Higher concentration of urinary 3-PBA associated with modest increased risk for ASD.•Pesticide exposure characterization difficult due to temporal variability and multiple sources.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Jacqueline M. Barkoski: Funding Acquisition, Conceptualization, Methodology, Writing- Original draft preparation, data curation, Project administration, Writing- reviewing and editing, Formal analysis; Claire Philippat: Conceptualization, Methodology, Writing- reviewing and editing; Daniel Tancredi: Methodology, Software, Validation, Formal Analysis; Rebecca Schmidt: Funding Acquisition, Writing- reviewing and editing, Methodology; Sally Ozonoff: Writing- reviewing and editing, Conceptualization, Methodology, Funding Acquisition; Dana Boyd Barr: Methodology, Writing- reviewing and editing, Resources; William Elms: Software, Validation; Deborah Bennett: Writing- reviewing and editing, Conceptualization, Methodology, Funding Acquisition, Supervision, Resources; Irva Hertz-Picciotto: Funding Acquisition, Writing- reviewing and editing, Methodology, Supervision
ISSN:0013-9351
1096-0953
1096-0953
DOI:10.1016/j.envres.2020.110495