Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate

Lassa virus (LASV) is the causative agent of Lassa Fever and is responsible for several hundred thousand infections and thousands of deaths annually in West Africa. LASV and the non-pathogenic Mopeia virus (MOPV) are both rodent-borne African arenaviruses. A live attenuated reassortant of MOPV and L...

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Bibliographic Details
Published in:	PLoS neglected tropical diseases Vol. 7; no. 9; p. e2406
Main Authors:	Zapata, Juan Carlos, Carrion, Ricardo, Patterson, Jean L., Crasta, Oswald, Zhang, Yan, Mani, Sachin, Jett, Marti, Poonia, Bhawna, Djavani, Mahmoud, White, David M., Lukashevich, Igor S., Salvato, Maria S.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.09.2013 Public Library of Science (PLoS)
Subjects:	Analysis Biology Blood Causes of Cluster analysis Disease Enzyme-Linked Immunosorbent Assay Fever Flow Cytometry Gene expression Gene Expression Profiling Genetic aspects Health aspects Health care Human subjects Humans Immune response Infections Interferon Lassa fever Lassa virus - growth & development Lassa virus - immunology Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - virology Medicine Microarray Analysis Mortality Pathogenesis Prevention Reassortant Viruses - growth & development Reassortant Viruses - immunology Reverse Transcriptase Polymerase Chain Reaction Rodents Signal transduction Vaccines Viral Vaccines - immunology Viruses United States Flow Cytometry Enzyme-Linked Immunosorbent Assay Microarray Analysis Humans Viral Vaccines Reassortant Viruses Gene Expression Profiling Leukocytes, Mononuclear Lassa virus Reverse Transcriptase Polymerase Chain Reaction
ISSN:	1935-2735, 1935-2727, 1935-2735
Online Access:	Get full text
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