COVID-19 and the role of chronic inflammation in patients with obesity

Coronavirus disease 2019 (COVID-19) and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a particular risk to people living with preexisting conditions that impair immune response or amplify pro-inflammatory response. Low-grade chronic systemic inflammation, common in p...

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Bibliographic Details
Published in:International Journal of Obesity Vol. 44; no. 8; pp. 1790 - 1792
Main Authors: Chiappetta, Sonja, Sharma, Arya M, Bottino, Vincenzo, Stier, Christine
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.08.2020
Subjects:
Adult
Arteriosclerosis
Atherosclerosis
Betacoronavirus - pathogenicity
Body Mass Index
Body size
C-reactive protein
Comorbidity
Coronavirus Infections - immunology
Coronavirus Infections - physiopathology
Coronavirus Infections - therapy
Coronaviruses
Correlation analysis
COVID-19
Cytokine Release Syndrome - physiopathology
Cytokine Release Syndrome - virology
Decision making
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - immunology
Diabetes Mellitus, Type 2 - physiopathology
Early Diagnosis
Female
Health Care Surveys
Humans
Hypertension
Immune response
Immune system
Immunosuppression
Immunosuppression Therapy - statistics & numerical data
Inflammation
Inflammation - physiopathology
Inflammation - virology
Inflammatory response
Interleukin 6
Linear Models
Male
Middle Aged
Mortality
Obesity
Obesity - complications
Obesity - immunology
Obesity - physiopathology
Pandemics
Physicians
Pneumonia, Viral - immunology
Pneumonia, Viral - physiopathology
Pneumonia, Viral - therapy
Regression analysis
Respiration, Artificial - statistics & numerical data
Respiratory diseases
Risk
Risk Assessment
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Viral diseases
ISSN:0307-0565, 1476-5497, 1476-5497
Online Access:Get full text
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Summary:Coronavirus disease 2019 (COVID-19) and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a particular risk to people living with preexisting conditions that impair immune response or amplify pro-inflammatory response. Low-grade chronic systemic inflammation, common in people with obesity, is associated with the development of atherosclerosis, type 2 diabetes, and hypertension, well known comorbidities that adversely affect the outcomes of patients with COVID-19. Risk stratification based on the Edmonton Obesity Staging System (EOSS), which classifies obesity based on the presence of medical, mental, and/or functional complications rather than on body mass index (BMI), has been shown to be a better predictor of all-cause mortality and it may well be that EOSS stages may better describe the risk of hyperinflammation in patients with COVID-19 infection. Analyzing a group of metabolic ill patients with obesity (EOSS 2 and 3), we found an increased interleukin-6 and linear regression analysis showed a positive correlation with C-reactive protein (CRP) (p = 0.014) and waist-to-hip-ratio (WHR) (p = 0.031). Physicians should be aware of these findings in patients with COVID-19 infection. Early identification of possible hyperinflammation could be fundamental and should guide decision making regarding hospitalization, early respiratory support, and therapy with immunosuppression to improve mortality.
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ISSN:0307-0565
1476-5497
1476-5497
DOI:10.1038/s41366-020-0597-4