Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

Aberrant replication causes cells lacking BRCA2 to enter mitosis with under-replicated DNA, which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we identify genome-wide the sites where MiDAS reactions occur when BRCA2 is abrogated. High-resolution profiling revealed that...

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Veröffentlicht in:	Molecular cell Jg. 82; H. 18; S. 3382
Hauptverfasser:	Groelly, Florian J, Dagg, Rebecca A, Petropoulos, Michalis, Rossetti, Giacomo G, Prasad, Birbal, Panagopoulos, Andreas, Paulsen, Teressa, Karamichali, Angeliki, Jones, Samuel E, Ochs, Fena, Dionellis, Vasilis S, Puig Lombardi, Emilia, Miossec, Matthieu J, Lockstone, Helen, Legube, Gaëlle, Blackford, Andrew N, Altmeyer, Matthias, Halazonetis, Thanos D, Tarsounas, Madalena
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.09.2022
Schlagworte:	Aphidicolin - pharmacology BRCA2 Protein - genetics Chromosome Fragile Sites - genetics DNA - genetics DNA Damage DNA Replication Genomic Instability Humans Mitosis - genetics genome stability transcription-replication conflicts MiDAS TRCs R-loops mitotic DNA synthesis BRCA2
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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