Extra View: Sirt1 Acts As A Gatekeeper Of Replication Initiation To Preserve Genomic Stability

Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellu...

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Vydáno v:	Nucleus Ročník 9; číslo 1; s. 307 - 313
Hlavní autoři:	Utani, Koichi, Aladjem, Mirit I.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Taylor & Francis 01.01.2018 Informa UK Limited
Témata:	Animalia Animals Cell cycle cell growth Chromatin Chromosome DNA DNA - genetics DNA repair DNA Replication DNA Replication - genetics Epigenetics Extra View genes Genomic Instability genomics Humans metabolism replication origin Silent Information Regulator Proteins, Saccharomyces cerevisiae Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism Sirtuin 1 Sirtuin 1 - metabolism Sirtuin 2 Sirtuin 2 - metabolism sirtuins yeasts Epigenetics Chromosome Chromatin DNA replication Cell cycle
ISSN:	1949-1034, 1949-1042, 1949-1042
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Abstract	Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellular metabolism including cell cycle progression and maintenance of genomic stability. In yeast, SIR2 interacts with replication origins and protein complexes that affect both replication origin usage and gene silencing. In metazoans, the largest SIR2 homolog, SIRT1, is implicated in epigenetic modifications, circadian signaling, DNA recombination and DNA repair. Until recently, very few studies investigated the role of mammalian SIRT1 in modulating DNA replication. We discuss a newly characterized interaction between human SIRT1 and the DNA replication machinery, reviewing data from recent studies that have investigated how complex signaling pathways that involve SIRT1 affect cellular growth regulatory circuits.
AbstractList	Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellular metabolism including cell cycle progression and maintenance of genomic stability. In yeast, SIR2 interacts with replication origins and protein complexes that affect both replication origin usage and gene silencing. In metazoans, the largest SIR2 homolog, SIRT1, is implicated in epigenetic modifications, circadian signaling, DNA recombination and DNA repair. Until recently, very few studies investigated the role of mammalian SIRT1 in modulating DNA replication. We discuss a newly characterized interaction between human SIRT1 and the DNA replication machinery, reviewing data from recent studies that have investigated how complex signaling pathways that involve SIRT1 affect cellular growth regulatory circuits. Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellular metabolism including cell cycle progression and maintenance of genomic stability. In yeast, SIR2 interacts with replication origins and protein complexes that affect both replication origin usage and gene silencing. In metazoans, the largest SIR2 homolog, SIRT1, is implicated in epigenetic modifications, circadian signaling, DNA recombination and DNA repair. Until recently, very few studies investigated the role of mammalian SIRT1 in modulating DNA replication. We discuss a newly characterized interaction between human SIRT1 and the DNA replication machinery, reviewing data from recent studies that have investigated how complex signaling pathways that involve SIRT1 affect cellular growth regulatory circuits.Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellular metabolism including cell cycle progression and maintenance of genomic stability. In yeast, SIR2 interacts with replication origins and protein complexes that affect both replication origin usage and gene silencing. In metazoans, the largest SIR2 homolog, SIRT1, is implicated in epigenetic modifications, circadian signaling, DNA recombination and DNA repair. Until recently, very few studies investigated the role of mammalian SIRT1 in modulating DNA replication. We discuss a newly characterized interaction between human SIRT1 and the DNA replication machinery, reviewing data from recent studies that have investigated how complex signaling pathways that involve SIRT1 affect cellular growth regulatory circuits.
Author	Utani, Koichi Aladjem, Mirit I.
Author_xml	– sequence: 1 givenname: Koichi orcidid: 0000-0002-8065-3161 surname: Utani fullname: Utani, Koichi organization: Department of Microbiology, Kanazawa Medical University – sequence: 2 givenname: Mirit I. surname: Aladjem fullname: Aladjem, Mirit I. email: aladjemm@mail.nih.gov organization: Developmental Therapeutics Branch, Center for Cancer Research, NCI, NIH
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SubjectTerms	Animalia Animals Cell cycle cell growth Chromatin Chromosome DNA DNA - genetics DNA repair DNA Replication DNA Replication - genetics Epigenetics Extra View genes Genomic Instability genomics Humans metabolism replication origin Silent Information Regulator Proteins, Saccharomyces cerevisiae Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism Sirtuin 1 Sirtuin 1 - metabolism Sirtuin 2 Sirtuin 2 - metabolism sirtuins yeasts
Title	Extra View: Sirt1 Acts As A Gatekeeper Of Replication Initiation To Preserve Genomic Stability
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