Risk factors for death in 1859 subjects with COVID-19

We studied 1859 subjects with confirmed COVID-19 from seven centers in Wuhan 1651 of whom recovered and 208 died. We interrogated diverse covariates for correlations with risk of death from COVID-19. In multi-variable Cox regression analyses increased hazards of in-hospital death were associated wit...

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Vydané v:	Leukemia Ročník 34; číslo 8; s. 2173 - 2183
Hlavní autori:	Chen, Lei, Yu, Jianming, He, Wenjuan, Chen, Li, Yuan, Guolin, Dong, Fang, Chen, Wenlan, Cao, Yulin, Yang, Jingyan, Cai, Liling, Wu, Di, Ran, Qijie, Li, Lei, Liu, Qiaomei, Ren, Wenxiang, Gao, Fei, Wang, Hongxiang, Chen, Zhichao, Gale, Robert Peter, Li, Qiubai, Hu, Yu
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.08.2020 Nature Publishing Group
Predmet:	692/499 692/699/255 Adult Aged Aged, 80 and over Betacoronavirus - isolation & purification Biomarkers - blood Cancer Research China Confidence intervals Coronavirus Infections - blood Coronavirus Infections - mortality Coronavirus Infections - pathology Coronaviruses COVID-19 Creatinine Critical Care Medicine Death Dimers Female Follow-Up Studies Hematology Humans Intensive Internal Medicine Lymphocytes Lymphocytes - pathology Male Medicine Medicine & Public Health Middle Aged Mortality Mortality - trends Neutrophils - pathology Oncology Pandemics Platelets Pneumonia, Viral - blood Pneumonia, Viral - mortality Pneumonia, Viral - pathology Prognosis Regression analysis Risk analysis Risk Factors ROC Curve SARS-CoV-2 Severity of Illness Index Statistical analysis Survival Rate Thromboplastin China
ISSN:	0887-6924, 1476-5551, 1476-5551
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Shrnutí:	We studied 1859 subjects with confirmed COVID-19 from seven centers in Wuhan 1651 of whom recovered and 208 died. We interrogated diverse covariates for correlations with risk of death from COVID-19. In multi-variable Cox regression analyses increased hazards of in-hospital death were associated with several admission covariates: (1) older age (HR = 1.04; 95% Confidence Interval [CI], 1.03, 1.06 per year increase; P < 0.001); (2) smoking (HR = 1.84 [1.17, 2.92]; P = 0.009); (3) admission temperature per °C increase (HR = 1.32 [1.07, 1.64]; P = 0.009); (4) Log 10 neutrophil-to-lymphocyte ratio (NLR; HR = 3.30 [2.10, 5.19]; P < 0.001); (5) platelets per 10 E + 9/L decrease (HR = 0.996 [0.994, 0.998]; P = 0.001); (6) activated partial thromboplastin (aPTT) per second increase (HR = 1.04 [1.02, 1.05]; P < 0.001); (7) Log 10 D-dimer per mg/l increase (HR = 3.00 [2.17, 4.16]; P < 0.001); and (8) Log 10 serum creatinine per μmol/L increase (HR = 4.55 [2.72, 7.62]; P < 0.001). In piecewise linear regression analyses Log 10 NLR the interval from ≥0.4 to ≤1.0 was significantly associated with an increased risk of death. Our data identify covariates associated with risk of in hospital death in persons with COVID-19.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0887-6924 1476-5551 1476-5551
DOI:	10.1038/s41375-020-0911-0