Targeting IL-1β and IL-17A Driven Inflammation during Influenza-Induced Exacerbations of Chronic Lung Inflammation

For patients with chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), exacerbations are life-threatening events causing acute respiratory distress that can even lead to hospitalization and death. Although a great deal of effort has been put into research of exacerbations and...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	PloS one Ročník 9; číslo 6; s. e98440
Hlavní autoři:	Sichelstiel, Anke, Yadava, Koshika, Trompette, Aurélien, Salami, Olawale, Iwakura, Yoichiro, Nicod, Laurent P., Marsland, Benjamin J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 11.06.2014 Public Library of Science (PLoS)
Témata:	Animals Antibodies, Neutralizing - immunology Antibodies, Neutralizing - therapeutic use Bacterial infections Biology Biology and Life Sciences Bronchitis Chronic Disease Chronic obstructive pulmonary disease Cytokines Emphysema Humans Infections Inflammation Influenza Influenza, Human - complications Influenza, Human - immunology Influenza, Human - therapy Interleukin Interleukin 1 Interleukin 1 Receptor Antagonist Protein - immunology Interleukin 1 Receptor Antagonist Protein - therapeutic use Interleukin-17 - antagonists & inhibitors Interleukin-17 - immunology Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - immunology Leukocytes (neutrophilic) Lung diseases Medicine Medicine and Health Sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Neutrophil Infiltration Neutrophilia Neutrophils Obstructive lung disease Orthomyxoviridae Infections - complications Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - therapy Pneumonia - complications Pneumonia - immunology Pneumonia - therapy Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - immunology Pulmonary Disease, Chronic Obstructive - therapy Recombinant Proteins - immunology Recombinant Proteins - therapeutic use Recruitment Rodents Therapeutic applications Viral infections Switzerland
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	For patients with chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), exacerbations are life-threatening events causing acute respiratory distress that can even lead to hospitalization and death. Although a great deal of effort has been put into research of exacerbations and potential treatment options, the exact underlying mechanisms are yet to be deciphered and no therapy that effectively targets the excessive inflammation is available. In this study, we report that interleukin-1β (IL-1β) and interleukin-17A (IL-17A) are key mediators of neutrophilic inflammation in influenza-induced exacerbations of chronic lung inflammation. Using a mouse model of disease, our data shows a role for IL-1β in mediating lung dysfunction, and in driving neutrophilic inflammation during the whole phase of viral infection. We further report a role for IL-17A as a mediator of IL-1β induced neutrophilia at early time points during influenza-induced exacerbations. Blocking of IL-17A or IL-1 resulted in a significant abrogation of neutrophil recruitment to the airways in the initial phase of infection or at the peak of viral replication, respectively. Therefore, IL-17A and IL-1β are potential targets for therapeutic treatment of viral exacerbations of chronic lung inflammation.
AbstractList	For patients with chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), exacerbations are life-threatening events causing acute respiratory distress that can even lead to hospitalization and death. Although a great deal of effort has been put into research of exacerbations and potential treatment options, the exact underlying mechanisms are yet to be deciphered and no therapy that effectively targets the excessive inflammation is available. In this study, we report that interleukin-1β (IL-1β) and interleukin-17A (IL-17A) are key mediators of neutrophilic inflammation in influenza-induced exacerbations of chronic lung inflammation. Using a mouse model of disease, our data shows a role for IL-1β in mediating lung dysfunction, and in driving neutrophilic inflammation during the whole phase of viral infection. We further report a role for IL-17A as a mediator of IL-1β induced neutrophilia at early time points during influenza-induced exacerbations. Blocking of IL-17A or IL-1 resulted in a significant abrogation of neutrophil recruitment to the airways in the initial phase of infection or at the peak of viral replication, respectively. Therefore, IL-17A and IL-1β are potential targets for therapeutic treatment of viral exacerbations of chronic lung inflammation For patients with chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), exacerbations are life-threatening events causing acute respiratory distress that can even lead to hospitalization and death. Although a great deal of effort has been put into research of exacerbations and potential treatment options, the exact underlying mechanisms are yet to be deciphered and no therapy that effectively targets the excessive inflammation is available. In this study, we report that interleukin-1β (IL-1β) and interleukin-17A (IL-17A) are key mediators of neutrophilic inflammation in influenza-induced exacerbations of chronic lung inflammation. Using a mouse model of disease, our data shows a role for IL-1β in mediating lung dysfunction, and in driving neutrophilic inflammation during the whole phase of viral infection. We further report a role for IL-17A as a mediator of IL-1β induced neutrophilia at early time points during influenza-induced exacerbations. Blocking of IL-17A or IL-1 resulted in a significant abrogation of neutrophil recruitment to the airways in the initial phase of infection or at the peak of viral replication, respectively. Therefore, IL-17A and IL-1β are potential targets for therapeutic treatment of viral exacerbations of chronic lung inflammation.For patients with chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), exacerbations are life-threatening events causing acute respiratory distress that can even lead to hospitalization and death. Although a great deal of effort has been put into research of exacerbations and potential treatment options, the exact underlying mechanisms are yet to be deciphered and no therapy that effectively targets the excessive inflammation is available. In this study, we report that interleukin-1β (IL-1β) and interleukin-17A (IL-17A) are key mediators of neutrophilic inflammation in influenza-induced exacerbations of chronic lung inflammation. Using a mouse model of disease, our data shows a role for IL-1β in mediating lung dysfunction, and in driving neutrophilic inflammation during the whole phase of viral infection. We further report a role for IL-17A as a mediator of IL-1β induced neutrophilia at early time points during influenza-induced exacerbations. Blocking of IL-17A or IL-1 resulted in a significant abrogation of neutrophil recruitment to the airways in the initial phase of infection or at the peak of viral replication, respectively. Therefore, IL-17A and IL-1β are potential targets for therapeutic treatment of viral exacerbations of chronic lung inflammation. For patients with chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), exacerbations are life-threatening events causing acute respiratory distress that can even lead to hospitalization and death. Although a great deal of effort has been put into research of exacerbations and potential treatment options, the exact underlying mechanisms are yet to be deciphered and no therapy that effectively targets the excessive inflammation is available. In this study, we report that interleukin-1β (IL-1β) and interleukin-17A (IL-17A) are key mediators of neutrophilic inflammation in influenza-induced exacerbations of chronic lung inflammation. Using a mouse model of disease, our data shows a role for IL-1β in mediating lung dysfunction, and in driving neutrophilic inflammation during the whole phase of viral infection. We further report a role for IL-17A as a mediator of IL-1β induced neutrophilia at early time points during influenza-induced exacerbations. Blocking of IL-17A or IL-1 resulted in a significant abrogation of neutrophil recruitment to the airways in the initial phase of infection or at the peak of viral replication, respectively. Therefore, IL-17A and IL-1β are potential targets for therapeutic treatment of viral exacerbations of chronic lung inflammation.
Author	Trompette, Aurélien Salami, Olawale Nicod, Laurent P. Marsland, Benjamin J. Sichelstiel, Anke Iwakura, Yoichiro Yadava, Koshika
AuthorAffiliation	2 Molecular Biomedicine, ETHZ, Zurich, Switzerland Helmholtz Zentrum München/Ludwig-Maximilians-University Munich, Germany 1 Faculty of Biology and Medicine, University of Lausanne, Service de Pneumologie, CHUV, Lausanne, Switzerland 3 Research Institute for Biomedical Sciences, Tokyo University of Science, Tokyo, Japan
AuthorAffiliation_xml	– name: 1 Faculty of Biology and Medicine, University of Lausanne, Service de Pneumologie, CHUV, Lausanne, Switzerland – name: 3 Research Institute for Biomedical Sciences, Tokyo University of Science, Tokyo, Japan – name: 2 Molecular Biomedicine, ETHZ, Zurich, Switzerland – name: Helmholtz Zentrum München/Ludwig-Maximilians-University Munich, Germany
Author_xml	– sequence: 1 givenname: Anke surname: Sichelstiel fullname: Sichelstiel, Anke – sequence: 2 givenname: Koshika surname: Yadava fullname: Yadava, Koshika – sequence: 3 givenname: Aurélien surname: Trompette fullname: Trompette, Aurélien – sequence: 4 givenname: Olawale surname: Salami fullname: Salami, Olawale – sequence: 5 givenname: Yoichiro surname: Iwakura fullname: Iwakura, Yoichiro – sequence: 6 givenname: Laurent P. surname: Nicod fullname: Nicod, Laurent P. – sequence: 7 givenname: Benjamin J. surname: Marsland fullname: Marsland, Benjamin J.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24918427$$D View this record in MEDLINE/PubMed
BookMark	eNp9ks9u1DAQxiNURP_AGyCIxIVLFttx7JgDUlUKrLQSl3K2Zu3J1qusvdhJBTwWD8Iz4e5mq7ZCnDwa_-bzjL85LY588FgULymZ0VrSd-swRg_9bJvTM0JUyzl5UpxQVbNKMFIf3YuPi9OU1oQ0dSvEs-KYcUVbzuRJka4grnBwflXOFxX987sEb3ehPC8_RneDvpz7rofNBgYXfGnHuINzbkT_C6q5t6NBW17-AINxuaNSGbry4joG70y5GCf-oPG8eNpBn_DFdJ4V3z5dXl18qRZfP88vzheVaZQYqla2wLGxBMA2oCxTVtFGdWBsraQSsmHQIRrFJLaEiGXHBCB0RrUGl6Srz4rXe91tH5Ke_itp2tQNIUxxlYn5nrAB1nob3QbiTx3A6V0ixJWGODjTo7aSNEuiiETJeN0y1VGRfZCNEJRZDlnrw_TauNygNeiHCP0D0Yc33l3rVbjRPNtSS5IF3k4CMXwfMQ1645LBvgePYdz3LRgTNc_om0fov6d7db-ju1YO7meA7wETQ0oRuzuEEn27ZAdZfbtkelqyXPb-UZlxw87ZPJfr_1_8F4Nf28c
CitedBy_id	crossref_primary_10_1165_rcmb_2022_0209OC crossref_primary_10_3390_biomedicines9010053 crossref_primary_10_1007_s00705_016_3093_3 crossref_primary_10_1038_s41598_019_38864_5 crossref_primary_10_1165_rcmb_2021_0545TR crossref_primary_10_3389_fimmu_2021_727941 crossref_primary_10_3389_fmicb_2016_01147 crossref_primary_10_1378_chest_14_3138 crossref_primary_10_1186_s12865_020_00381_w crossref_primary_10_1165_rcmb_2018_0078ED crossref_primary_10_1183_13993003_02434_2016 crossref_primary_10_1016_j_cimid_2019_101356 crossref_primary_10_3892_ijmm_2020_4608 crossref_primary_10_1073_pnas_2004688117 crossref_primary_10_1155_2016_9348037 crossref_primary_10_4049_jimmunol_1800671 crossref_primary_10_1007_s00204_024_03691_9 crossref_primary_10_3390_vetsci11110555 crossref_primary_10_1016_j_imbio_2020_151981 crossref_primary_10_1111_resp_14141 crossref_primary_10_1186_s12879_019_4213_y crossref_primary_10_1016_j_jaut_2020_102468 crossref_primary_10_21292_2075_1230_2020_98_1_22_26 crossref_primary_10_1007_s00011_022_01602_1 crossref_primary_10_2147_JIR_S324323 crossref_primary_10_1016_j_cyto_2020_155400 crossref_primary_10_1183_13993003_00763_2015 crossref_primary_10_1155_2015_640846
Cites_doi	10.4049/jimmunol.0900995 10.1165/rcmb.2004-0309OC 10.1126/science.1196017 10.4049/jimmunol.0803154 10.1042/CS20110340 10.2147/COPD.S1210 10.1164/rccm.200506-859OC 10.1183/09031936.03.00031402 10.1513/pats.2306030 10.1136/thx.2005.041806 10.1111/j.1600-0668.2004.00290.x 10.1016/j.immuni.2009.02.007 10.1164/rccm.200208-794OC 10.1136/thorax.58.1.37 10.1136/thx.2005.040527 10.1371/journal.pone.0013251 10.1111/j.1365-2249.2009.03965.x 10.1084/jem.20060285 10.1016/j.rmed.2005.08.022 10.1378/chest.07-0530 10.1164/ajrccm.164.9.2105011 10.1002/eji.200636662 10.1183/09031936.03.00027003 10.1183/09031936.05.00043405 10.4049/jimmunol.180.2.1169 10.1016/S0140-6736(07)61382-8 10.1016/j.ejphar.2004.07.047 10.1186/1471-2466-9-11 10.1165/ajrcmb.21.2.3605 10.1126/scitranslmed.3003041 10.1084/jem.187.9.1463 10.1371/journal.pone.0020333 10.1136/thx.2004.027946 10.1378/chest.115.3.829 10.1183/09031936.00043710 10.1183/09031936.00158110 10.1016/j.immuni.2009.08.001 10.1165/rcmb.2008-0038OC 10.1164/ajrccm.163.2.2003122 10.1124/pr.56.4.2 10.2165/00003495-200969050-00004 10.1378/chest.09-3058 10.1183/09031936.97.10040846 10.1513/pats.200905-025DS 10.1016/S0002-9343(03)00353-X 10.1016/j.rmed.2005.02.041 10.1152/ajplung.00150.2009 10.1183/09031936.00113909 10.1136/thoraxjnl-2011-201518 10.1164/ajrccm.161.5.9908022 10.1164/ajrccm.157.5.9709032 10.1038/labinvest.3780397 10.1080/15412550802092969 10.1016/S1579-2129(11)70043-X 10.1371/journal.pone.0086166 10.1371/journal.pone.0028457
ContentType	Journal Article
Copyright	2014 Sichelstiel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 Sichelstiel et al 2014 Sichelstiel et al
Copyright_xml	– notice: 2014 Sichelstiel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2014 Sichelstiel et al 2014 Sichelstiel et al
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU COVID D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA
DOI	10.1371/journal.pone.0098440
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Database ProQuest Central Essentials Biological Science Collection ProQuest Central (NC Live) Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College Coronavirus Research Database ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection Coronavirus Research Database ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Agricultural Science Database MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Medicine Biology
DocumentTitleAlternate	Viral Exacerbation of Chronic Lung Inflammation
EISSN	1932-6203
ExternalDocumentID	1535002949 oai_doaj_org_article_d705b0907e7243829f16137756612d4a PMC4053370 3331733671 24918427 10_1371_journal_pone_0098440
Genre	Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	Switzerland
GeographicLocations_xml	– name: Switzerland
GroupedDBID	--- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV CGR CUY CVF ECM EIF IPNFZ NPM PV9 RIG RZL 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K COVID DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM - 02 AAPBV ABPTK ADACO BBAFP BBORY KM
ID	FETCH-LOGICAL-c596t-878a4e5d0aad5a9d29d9159facd39796752afeec927e8006bf26aeafc98ceb0f3
IEDL.DBID	FPL
ISICitedReferencesCount	36
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000338631000017&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-6203
IngestDate	Fri Nov 26 17:12:47 EST 2021 Fri Oct 03 12:21:48 EDT 2025 Tue Nov 04 01:49:59 EST 2025 Mon Sep 08 07:15:21 EDT 2025 Tue Oct 07 07:37:02 EDT 2025 Mon Jul 21 05:56:47 EDT 2025 Sat Nov 29 02:23:55 EST 2025 Tue Nov 18 21:29:09 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	6
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c596t-878a4e5d0aad5a9d29d9159facd39796752afeec927e8006bf26aeafc98ceb0f3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: AS BJM LN. Performed the experiments: AS KY AT OS. Analyzed the data: AS KY AT OS. Contributed reagents/materials/analysis tools: YI. Wrote the paper: AS BJM KY.
OpenAccessLink	http://dx.doi.org/10.1371/journal.pone.0098440
PMID	24918427
PQID	1535002949
PQPubID	1436336
ParticipantIDs	plos_journals_1535002949 doaj_primary_oai_doaj_org_article_d705b0907e7243829f16137756612d4a pubmedcentral_primary_oai_pubmedcentral_nih_gov_4053370 proquest_miscellaneous_1535622634 proquest_journals_1535002949 pubmed_primary_24918427 crossref_primary_10_1371_journal_pone_0098440 crossref_citationtrail_10_1371_journal_pone_0098440
PublicationCentury	2000
PublicationDate	2014-06-11
PublicationDateYYYYMMDD	2014-06-11
PublicationDate_xml	– month: 06 year: 2014 text: 2014-06-11 day: 11
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco – name: San Francisco, USA
PublicationTitle	PloS one
PublicationTitleAlternate	PLoS One
PublicationYear	2014
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	I Couillin (ref22) 2009; 183 EM Drost (ref49) 2005; 60 PJ Barnes (ref1) 2004; 56 L Larsson (ref36) 2004; 14 TA Seemungal (ref6) 1998; 157 A Di Stefano (ref41) 2009; 157 U Lappalainen (ref24) 2005; 32 M Hoogendoorn (ref47) 2011; 37 K Chen (ref52) 2011; 6 FM Botelho (ref20) 2011; 6 Y Qiu (ref15) 2003; 168 U Sajjan (ref34) 2009; 297 JR Hurst (ref9) 2005; 26 E Doz (ref23) 2008; 180 M Shan (ref53) 2012; 4 TA Seemungal (ref50) 2000; 161 WM Thurlbeck (ref31) 1967; 95 PJ Daffern (ref39) 1999; 21 W Szafranski (ref57) 2003; 21 SI Rennard (ref56) 2009; 69 FW Ko (ref13) 2007; 132 SD Aaron (ref16) 2001; 163 ref5 PM Calverley (ref55) 2003; 22 WC Tan (ref14) 2003; 115 B Balbi (ref48) 1997; 10 T Seemungal (ref10) 2001; 164 JA Wedzicha (ref46) 2007; 370 GJ Gaschler (ref37) 2010; 36 CR Crowe (ref54) 2009; 183 P Kythreotis (ref29) 2009; 9 C Uyttenhove (ref33) 2006; 36 A Churg (ref21) 2009; 40 M Saetta (ref32) 1985; 131 NS Pauwels (ref26) 2011; 38 M Mihara (ref40) 2012; 122 C Sutton (ref44) 2006; 203 SS Hacievliyagil (ref51) 2006; 100 G Rohde (ref8) 2003; 58 AL Kersul (ref28) 2011; 47 P Castro (ref27) 2004; 498 A Papi (ref7) 2006; 173 E Bathoorn (ref18) 2008; 3 PJ Barnes (ref58) 2010; 330 Y Han (ref38) 2014; 9 JJ Soler-Cataluna (ref4) 2005; 60 R Horai (ref30) 1998; 187 JD Hasday (ref35) 1999; 115 GC Donaldson (ref2) 2006; 61 EC Lucey (ref25) 2002; 82 S Sethi (ref3) 2009; 6 A Potena (ref12) 2007; 2 C Doe (ref42) 2010; 138 CM Bauer (ref19) 2010; 5 CE Sutton (ref45) 2009; 31 C Gessner (ref17) 2005; 99 H Perttunen (ref59) 2008; 5 Y Chung (ref43) 2009; 30 JA Wedzicha (ref11) 2004; 1 19682929 - Immunity. 2009 Aug 21;31(2):331-41 20929796 - Science. 2010 Oct 1;330(6000):40-1 17048276 - Eur J Immunol. 2006 Nov;36(11):2868-74 21647421 - PLoS One. 2011;6(5):e20333 18931327 - Am J Respir Cell Mol Biol. 2009 Apr;40(4):482-90 17765528 - Lancet. 2007 Sep 1;370(9589):786-96 22684094 - Thorax. 2012 Nov;67(11):957-63 19783685 - J Immunol. 2009 Oct 15;183(8):5301-10 15500635 - Indoor Air. 2004 Dec;14(6):421-4 22029668 - Clin Sci (Lond). 2012 Feb;122(4):143-59 4003921 - Am Rev Respir Dis. 1985 May;131(5):764-9 20413532 - Eur Respir J. 2010 Nov;36(5):1131-42 16140223 - Respir Med. 2005 Oct;99(10):1229-40 22163019 - PLoS One. 2011;6(12):e28457 14680078 - Eur Respir J. 2003 Dec;22(6):912-9 12857718 - Am J Respir Crit Care Med. 2003 Oct 15;168(8):968-75 10084499 - Chest. 1999 Mar;115(3):829-35 10423410 - Am J Respir Cell Mol Biol. 1999 Aug;21(2):259-67 18686731 - Int J Chron Obstruct Pulmon Dis. 2008;3(2):217-29 20595157 - Eur Respir J. 2011 Mar;37(3):508-15 19344528 - BMC Pulm Med. 2009;9:11 18568840 - COPD. 2008 Jun;5(3):163-9 20967263 - PLoS One. 2010;5(10):e13251 19368417 - Drugs. 2009;69(5):549-65 11719299 - Am J Respir Crit Care Med. 2001 Nov 1;164(9):1618-23 18268922 - Int J Chron Obstruct Pulmon Dis. 2007;2(4):477-83 24465940 - PLoS One. 2014;9(1):e86166 19741263 - Proc Am Thorac Soc. 2009 Sep 15;6(6):532-4 15668323 - Am J Respir Cell Mol Biol. 2005 Apr;32(4):311-8 15364006 - Eur J Pharmacol. 2004 Sep 13;498(1-3):279-86 21622588 - Eur Respir J. 2011 Nov;38(5):1019-28 18178857 - J Immunol. 2008 Jan 15;180(2):1169-78 9150323 - Eur Respir J. 1997 Apr;10(4):846-50 17573516 - Chest. 2007 Sep;132(3):900-8 16214322 - Respir Med. 2006 May;100(5):846-54 11796828 - Lab Invest. 2002 Jan;82(1):79-85 15790984 - Thorax. 2005 Apr;60(4):293-300 16818675 - J Exp Med. 2006 Jul 10;203(7):1685-91 5337140 - Am Rev Respir Dis. 1967 May;95(5):752-64 19748999 - Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L931-44 11179105 - Am J Respir Crit Care Med. 2001 Feb;163(2):349-55 12570112 - Eur Respir J. 2003 Jan;21(1):74-81 16055622 - Thorax. 2005 Nov;60(11):925-31 21454005 - Arch Bronconeumol. 2011 Apr;47(4):176-83 16113423 - Proc Am Thorac Soc. 2004;1(2):115-20 15602009 - Pharmacol Rev. 2004 Dec;56(4):515-48 16443707 - Thorax. 2006 Feb;61(2):164-8 12967691 - Am J Med. 2003 Sep;115(4):272-7 16484677 - Am J Respir Crit Care Med. 2006 May 15;173(10):1114-21 9565638 - J Exp Med. 1998 May 4;187(9):1463-75 9603117 - Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1418-22 19362022 - Immunity. 2009 Apr 17;30(4):576-87 16264045 - Eur Respir J. 2005 Nov;26(5):846-52 19604272 - Clin Exp Immunol. 2009 Aug;157(2):316-24 20007584 - J Immunol. 2009 Dec 15;183(12):8195-202 12511718 - Thorax. 2003 Jan;58(1):37-42 20538817 - Chest. 2010 Nov;138(5):1140-7 22261033 - Sci Transl Med. 2012 Jan 18;4(117):117ra9 10806163 - Am J Respir Crit Care Med. 2000 May;161(5):1608-13
References_xml	– volume: 183 start-page: 5301 year: 2009 ident: ref54 article-title: Critical role of IL-17RA in immunopathology of influenza infection publication-title: J Immunol doi: 10.4049/jimmunol.0900995 – volume: 32 start-page: 311 year: 2005 ident: ref24 article-title: Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2004-0309OC – volume: 330 start-page: 40 year: 2010 ident: ref58 article-title: Medicine. Neutrophils find smoke attractive publication-title: Science doi: 10.1126/science.1196017 – volume: 183 start-page: 8195 year: 2009 ident: ref22 article-title: IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema publication-title: J Immunol doi: 10.4049/jimmunol.0803154 – volume: 122 start-page: 143 year: 2012 ident: ref40 article-title: IL-6/IL-6 receptor system and its role in physiological and pathological conditions publication-title: Clin Sci (Lond) doi: 10.1042/CS20110340 – volume: 3 start-page: 217 year: 2008 ident: ref18 article-title: Airways inflammation and treatment during acute exacerbations of COPD publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S1210 – volume: 173 start-page: 1114 year: 2006 ident: ref7 article-title: Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200506-859OC – volume: 21 start-page: 74 year: 2003 ident: ref57 article-title: Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease publication-title: Eur Respir J doi: 10.1183/09031936.03.00031402 – volume: 1 start-page: 115 year: 2004 ident: ref11 article-title: Role of viruses in exacerbations of chronic obstructive pulmonary disease publication-title: Proc Am Thorac Soc doi: 10.1513/pats.2306030 – volume: 61 start-page: 164 year: 2006 ident: ref2 article-title: COPD exacerbations.1: Epidemiology publication-title: Thorax doi: 10.1136/thx.2005.041806 – volume: 14 start-page: 421 year: 2004 ident: ref36 article-title: Tobacco smoking increases dramatically air concentrations of endotoxin publication-title: Indoor Air doi: 10.1111/j.1600-0668.2004.00290.x – volume: 2 start-page: 477 year: 2007 ident: ref12 article-title: Pathophysiology of viral-induced exacerbations of COPD publication-title: Int J Chron Obstruct Pulmon Dis – volume: 30 start-page: 576 year: 2009 ident: ref43 article-title: Critical regulation of early Th17 cell differentiation by interleukin-1 signaling publication-title: Immunity doi: 10.1016/j.immuni.2009.02.007 – volume: 95 start-page: 752 year: 1967 ident: ref31 article-title: Measurement of pulmonary emphysema publication-title: Am Rev Respir Dis – volume: 168 start-page: 968 year: 2003 ident: ref15 article-title: Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200208-794OC – volume: 58 start-page: 37 year: 2003 ident: ref8 article-title: Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study publication-title: Thorax doi: 10.1136/thorax.58.1.37 – volume: 60 start-page: 925 year: 2005 ident: ref4 article-title: Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease publication-title: Thorax doi: 10.1136/thx.2005.040527 – volume: 5 start-page: e13251 year: 2010 ident: ref19 article-title: Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection publication-title: PLoS One doi: 10.1371/journal.pone.0013251 – volume: 157 start-page: 316 year: 2009 ident: ref41 article-title: T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2009.03965.x – volume: 203 start-page: 1685 year: 2006 ident: ref44 article-title: A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis publication-title: J Exp Med doi: 10.1084/jem.20060285 – volume: 100 start-page: 846 year: 2006 ident: ref51 article-title: Association between cytokines in induced sputum and severity of chronic obstructive pulmonary disease publication-title: Respir Med doi: 10.1016/j.rmed.2005.08.022 – volume: 132 start-page: 900 year: 2007 ident: ref13 article-title: Viral etiology of acute exacerbations of COPD in Hong Kong publication-title: Chest doi: 10.1378/chest.07-0530 – volume: 164 start-page: 1618 year: 2001 ident: ref10 article-title: Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.164.9.2105011 – volume: 36 start-page: 2868 year: 2006 ident: ref33 article-title: Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis publication-title: Eur J Immunol doi: 10.1002/eji.200636662 – volume: 22 start-page: 912 year: 2003 ident: ref55 article-title: Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease publication-title: Eur Respir J doi: 10.1183/09031936.03.00027003 – volume: 26 start-page: 846 year: 2005 ident: ref9 article-title: Epidemiological relationships between the common cold and exacerbation frequency in COPD publication-title: Eur Respir J doi: 10.1183/09031936.05.00043405 – volume: 180 start-page: 1169 year: 2008 ident: ref23 article-title: Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent publication-title: J Immunol doi: 10.4049/jimmunol.180.2.1169 – volume: 370 start-page: 786 year: 2007 ident: ref46 article-title: COPD exacerbations: defining their cause and prevention publication-title: Lancet doi: 10.1016/S0140-6736(07)61382-8 – volume: 498 start-page: 279 year: 2004 ident: ref27 article-title: Inhibition of interleukin-1beta reduces mouse lung inflammation induced by exposure to cigarette smoke publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2004.07.047 – volume: 9 start-page: 11 year: 2009 ident: ref29 article-title: Plasma leptin and insulin-like growth factor I levels during acute exacerbations of chronic obstructive pulmonary disease publication-title: BMC Pulm Med doi: 10.1186/1471-2466-9-11 – volume: 21 start-page: 259 year: 1999 ident: ref39 article-title: Multiple epithelial cell-derived factors enhance neutrophil survival. Regulation by glucocorticoids and tumor necrosis factor-alpha publication-title: Am J Respir Cell Mol Biol doi: 10.1165/ajrcmb.21.2.3605 – volume: 4 start-page: 117ra119 year: 2012 ident: ref53 article-title: Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3003041 – volume: 187 start-page: 1463 year: 1998 ident: ref30 article-title: Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion publication-title: J Exp Med doi: 10.1084/jem.187.9.1463 – volume: 6 start-page: e20333 year: 2011 ident: ref52 article-title: IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke publication-title: PLoS One doi: 10.1371/journal.pone.0020333 – volume: 60 start-page: 293 year: 2005 ident: ref49 article-title: Oxidative stress and airway inflammation in severe exacerbations of COPD publication-title: Thorax doi: 10.1136/thx.2004.027946 – volume: 115 start-page: 829 year: 1999 ident: ref35 article-title: Bacterial endotoxin is an active component of cigarette smoke publication-title: Chest doi: 10.1378/chest.115.3.829 – volume: 37 start-page: 508 year: 2011 ident: ref47 article-title: Case fatality of COPD exacerbations: a meta-analysis and statistical modelling approach publication-title: Eur Respir J doi: 10.1183/09031936.00043710 – volume: 38 start-page: 1019 year: 2011 ident: ref26 article-title: Role of IL-1alpha and the Nlrp3/caspase-1/IL-1beta axis in cigarette smoke-induced pulmonary inflammation and COPD publication-title: Eur Respir J doi: 10.1183/09031936.00158110 – volume: 31 start-page: 331 year: 2009 ident: ref45 article-title: Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity publication-title: Immunity doi: 10.1016/j.immuni.2009.08.001 – volume: 40 start-page: 482 year: 2009 ident: ref21 article-title: The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2008-0038OC – volume: 163 start-page: 349 year: 2001 ident: ref16 article-title: Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.163.2.2003122 – volume: 56 start-page: 515 year: 2004 ident: ref1 article-title: Mediators of chronic obstructive pulmonary disease publication-title: Pharmacol Rev doi: 10.1124/pr.56.4.2 – volume: 69 start-page: 549 year: 2009 ident: ref56 article-title: Efficacy and tolerability of budesonide/formoterol in one hydrofluoroalkane pressurized metered-dose inhaler in patients with chronic obstructive pulmonary disease: results from a 1-year randomized controlled clinical trial publication-title: Drugs doi: 10.2165/00003495-200969050-00004 – volume: 138 start-page: 1140 year: 2010 ident: ref42 article-title: Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD publication-title: Chest doi: 10.1378/chest.09-3058 – volume: 10 start-page: 846 year: 1997 ident: ref48 article-title: Increased bronchoalveolar granulocytes and granulocyte/macrophage colony-stimulating factor during exacerbations of chronic bronchitis publication-title: Eur Respir J doi: 10.1183/09031936.97.10040846 – volume: 6 start-page: 532 year: 2009 ident: ref3 article-title: New paradigms in the pathogenesis of chronic obstructive pulmonary disease II publication-title: Proc Am Thorac Soc doi: 10.1513/pats.200905-025DS – volume: 115 start-page: 272 year: 2003 ident: ref14 article-title: Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease publication-title: Am J Med doi: 10.1016/S0002-9343(03)00353-X – volume: 99 start-page: 1229 year: 2005 ident: ref17 article-title: Exhaled breath condensate cytokine patterns in chronic obstructive pulmonary disease publication-title: Respir Med doi: 10.1016/j.rmed.2005.02.041 – volume: 297 start-page: L931 year: 2009 ident: ref34 article-title: Elastase- and LPS-exposed mice display altered responses to rhinovirus infection publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00150.2009 – volume: 36 start-page: 1131 year: 2010 ident: ref37 article-title: Mechanisms of clearance of nontypeable Haemophilus influenzae from cigarette smoke-exposed mouse lungs publication-title: Eur Respir J doi: 10.1183/09031936.00113909 – ident: ref5 doi: 10.1136/thoraxjnl-2011-201518 – volume: 161 start-page: 1608 year: 2000 ident: ref50 article-title: Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.161.5.9908022 – volume: 157 start-page: 1418 year: 1998 ident: ref6 article-title: Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.157.5.9709032 – volume: 82 start-page: 79 year: 2002 ident: ref25 article-title: Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1beta receptor-deficient mice publication-title: Lab Invest doi: 10.1038/labinvest.3780397 – volume: 5 start-page: 163 year: 2008 ident: ref59 article-title: Beta2-agonists potentiate corticosteroid-induced neutrophil survival publication-title: COPD doi: 10.1080/15412550802092969 – volume: 47 start-page: 176 year: 2011 ident: ref28 article-title: Molecular mechanisms of inflammation during exacerbations of chronic obstructive pulmonary disease publication-title: Arch Bronconeumol doi: 10.1016/S1579-2129(11)70043-X – volume: 131 start-page: 764 year: 1985 ident: ref32 article-title: Destructive index: a measurement of lung parenchymal destruction in smokers publication-title: Am Rev Respir Dis – volume: 9 start-page: e86166 year: 2014 ident: ref38 article-title: Influenza virus-induced lung inflammation was modulated by cigarette smoke exposure in mice publication-title: PLoS One doi: 10.1371/journal.pone.0086166 – volume: 6 start-page: e28457 year: 2011 ident: ref20 article-title: IL-1alpha/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice publication-title: PLoS One doi: 10.1371/journal.pone.0028457 – reference: 12570112 - Eur Respir J. 2003 Jan;21(1):74-81 – reference: 12511718 - Thorax. 2003 Jan;58(1):37-42 – reference: 15500635 - Indoor Air. 2004 Dec;14(6):421-4 – reference: 10806163 - Am J Respir Crit Care Med. 2000 May;161(5):1608-13 – reference: 15668323 - Am J Respir Cell Mol Biol. 2005 Apr;32(4):311-8 – reference: 19368417 - Drugs. 2009;69(5):549-65 – reference: 9565638 - J Exp Med. 1998 May 4;187(9):1463-75 – reference: 20929796 - Science. 2010 Oct 1;330(6000):40-1 – reference: 16264045 - Eur Respir J. 2005 Nov;26(5):846-52 – reference: 10084499 - Chest. 1999 Mar;115(3):829-35 – reference: 19783685 - J Immunol. 2009 Oct 15;183(8):5301-10 – reference: 18931327 - Am J Respir Cell Mol Biol. 2009 Apr;40(4):482-90 – reference: 16818675 - J Exp Med. 2006 Jul 10;203(7):1685-91 – reference: 21647421 - PLoS One. 2011;6(5):e20333 – reference: 18178857 - J Immunol. 2008 Jan 15;180(2):1169-78 – reference: 17573516 - Chest. 2007 Sep;132(3):900-8 – reference: 19748999 - Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L931-44 – reference: 12857718 - Am J Respir Crit Care Med. 2003 Oct 15;168(8):968-75 – reference: 24465940 - PLoS One. 2014;9(1):e86166 – reference: 10423410 - Am J Respir Cell Mol Biol. 1999 Aug;21(2):259-67 – reference: 16484677 - Am J Respir Crit Care Med. 2006 May 15;173(10):1114-21 – reference: 5337140 - Am Rev Respir Dis. 1967 May;95(5):752-64 – reference: 20595157 - Eur Respir J. 2011 Mar;37(3):508-15 – reference: 11796828 - Lab Invest. 2002 Jan;82(1):79-85 – reference: 16140223 - Respir Med. 2005 Oct;99(10):1229-40 – reference: 12967691 - Am J Med. 2003 Sep;115(4):272-7 – reference: 14680078 - Eur Respir J. 2003 Dec;22(6):912-9 – reference: 16113423 - Proc Am Thorac Soc. 2004;1(2):115-20 – reference: 18568840 - COPD. 2008 Jun;5(3):163-9 – reference: 19344528 - BMC Pulm Med. 2009;9:11 – reference: 17765528 - Lancet. 2007 Sep 1;370(9589):786-96 – reference: 15602009 - Pharmacol Rev. 2004 Dec;56(4):515-48 – reference: 20967263 - PLoS One. 2010;5(10):e13251 – reference: 11719299 - Am J Respir Crit Care Med. 2001 Nov 1;164(9):1618-23 – reference: 17048276 - Eur J Immunol. 2006 Nov;36(11):2868-74 – reference: 22163019 - PLoS One. 2011;6(12):e28457 – reference: 20007584 - J Immunol. 2009 Dec 15;183(12):8195-202 – reference: 19741263 - Proc Am Thorac Soc. 2009 Sep 15;6(6):532-4 – reference: 18268922 - Int J Chron Obstruct Pulmon Dis. 2007;2(4):477-83 – reference: 22261033 - Sci Transl Med. 2012 Jan 18;4(117):117ra9 – reference: 4003921 - Am Rev Respir Dis. 1985 May;131(5):764-9 – reference: 16214322 - Respir Med. 2006 May;100(5):846-54 – reference: 16443707 - Thorax. 2006 Feb;61(2):164-8 – reference: 9150323 - Eur Respir J. 1997 Apr;10(4):846-50 – reference: 21622588 - Eur Respir J. 2011 Nov;38(5):1019-28 – reference: 11179105 - Am J Respir Crit Care Med. 2001 Feb;163(2):349-55 – reference: 22684094 - Thorax. 2012 Nov;67(11):957-63 – reference: 18686731 - Int J Chron Obstruct Pulmon Dis. 2008;3(2):217-29 – reference: 20538817 - Chest. 2010 Nov;138(5):1140-7 – reference: 19604272 - Clin Exp Immunol. 2009 Aug;157(2):316-24 – reference: 9603117 - Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1418-22 – reference: 16055622 - Thorax. 2005 Nov;60(11):925-31 – reference: 19682929 - Immunity. 2009 Aug 21;31(2):331-41 – reference: 15790984 - Thorax. 2005 Apr;60(4):293-300 – reference: 22029668 - Clin Sci (Lond). 2012 Feb;122(4):143-59 – reference: 21454005 - Arch Bronconeumol. 2011 Apr;47(4):176-83 – reference: 15364006 - Eur J Pharmacol. 2004 Sep 13;498(1-3):279-86 – reference: 19362022 - Immunity. 2009 Apr 17;30(4):576-87 – reference: 20413532 - Eur Respir J. 2010 Nov;36(5):1131-42
SSID	ssj0053866
Score	2.3137476
Snippet	For patients with chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), exacerbations are life-threatening events causing acute...
SourceID	plos doaj pubmedcentral proquest pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e98440
SubjectTerms	Animals Antibodies, Neutralizing - immunology Antibodies, Neutralizing - therapeutic use Bacterial infections Biology Biology and Life Sciences Bronchitis Chronic Disease Chronic obstructive pulmonary disease Cytokines Emphysema Humans Infections Inflammation Influenza Influenza, Human - complications Influenza, Human - immunology Influenza, Human - therapy Interleukin Interleukin 1 Interleukin 1 Receptor Antagonist Protein - immunology Interleukin 1 Receptor Antagonist Protein - therapeutic use Interleukin-17 - antagonists & inhibitors Interleukin-17 - immunology Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - immunology Leukocytes (neutrophilic) Lung diseases Medicine Medicine and Health Sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Neutrophil Infiltration Neutrophilia Neutrophils Obstructive lung disease Orthomyxoviridae Infections - complications Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - therapy Pneumonia - complications Pneumonia - immunology Pneumonia - therapy Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - immunology Pulmonary Disease, Chronic Obstructive - therapy Recombinant Proteins - immunology Recombinant Proteins - therapeutic use Recruitment Rodents Therapeutic applications Viral infections
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwEB2higMXRPlqSkFG4gAHt7HjxOtjQVQgoYpDkXqLJrEtKq2y1WYXIX5Wf0h_E-OPrHZRpV64rWLvbjLz7HmTsZ8B3qmqEahczbVAyZXQDUdVl7xG39GEaClG-njYhD4_n11emu9bR32FNWFJHjgZ7sTqsu5KSuGclqFoZTxxlEproiFCWhWpEbGeKZlKczCN4qbJG-UqLU6yX46vF4M7DhKaKrzs2ApEUa8_6JvOF-NdXPPfJZNbMejsCTzO5JGdppvehwdueAr7eXiO7H3WkP7wDMaLuMKb4hL7-o2L2xuGg40f9SmzyzDFMcIWwSFtXWRpu2K8tnbDH-SUq5PXLXO_sSfTpxd7bOFZn-R02Xyd-0-_8Rx-nH2--PSF5_MVeF-bZkUT4Sy4yZaItkZjpbGG2I3H3oZqH6USEr1zvZHaEa9sOi8bdOh7M-tdV_rqBewNZNEDYGhniFp6o4VTnliP7Dqvne8E-to4UUA1Gbvts_h4OANj3saKmqYkJJmwDS5qs4sK4JtvXSfxjXv6fwx-3PQN0tnxAgGqzYBq7wNUAQcBBdMfjC3FhDoUL5Up4GhCxt3NbzfNNEhD5QUHt1inPg0R3UoV8DIBaXOTlP9Sli11AXoHYjtPsdsyXP2MQuAqbKTW5eH_eOxX8Ii4oAqr4IQ4gr3Vcu1ew8P-1-pqXL6Jo-svJ8Yr5w priority: 102 providerName: Directory of Open Access Journals – databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BeYgL0PJooCAjcYBD2thx4vUJFWhFpVL1UKTeIie2oVKVLJtdBPwsfgi_iRnHWbqoggO3KHae8_Bnz_gbgOcyL7mRrkgVNyKVXJWpkUWWFsbX6BAtjpE-FJtQR0eT01N9HBfc-phWOfrE4Kht19Aa-Q5aZkEhJKlfTT-nVDWKoquxhMZVuEYsCXlI3TsePTHaclnG7XK54jtROtvTrnXbRKQpacnjwnAUWPuJ5fS86y9DnH8mTl4Yifbv_O833IXbEYOy3UFp1uGKazfgxlCV8tsG3Hwf4-0bsB5Nv2cvIj_1y3vQn4TscRzz2MFhyn_-YKa14VDtsrczcp_soPWoasO2SDZshQznFq79blKqF9I4y_a-mgbFOiwass6zSNXLDhex_3iP-_Bhf-_kzbs01m5Im0KXc3SyE1IBmxljC6Ot0FYjcvKmsRRJxGmKMN65RgvlELOWtRelccY3etK4OvP5A1hrUU6bwIydGKOE14o76RFRibr2yvmaG19oxxPIRxFWTSQ2p_oa51WI1imc4Az_tSLBV1HwCaTLq6YDscc_-r8m7Vj2JVrucKKbfayilVdWZUWd6Uw5JSjCqj0C6lwpxMxcWGkS2CTdGh_QV781IoGtUWcub362bEYHQFEd07puMfQpEUTnMoGHg3ouXxLn1jiDFyoBtaK4K1-x2tKefQok45I2aavs0d9f6zHcQgQpKXeO8y1Ym88W7glcb77Mz_rZ02CNvwBXc0E8 priority: 102 providerName: ProQuest
Title	Targeting IL-1β and IL-17A Driven Inflammation during Influenza-Induced Exacerbations of Chronic Lung Inflammation
URI	https://www.ncbi.nlm.nih.gov/pubmed/24918427 https://www.proquest.com/docview/1535002949 https://www.proquest.com/docview/1535622634 https://pubmed.ncbi.nlm.nih.gov/PMC4053370 https://doaj.org/article/d705b0907e7243829f16137756612d4a http://dx.doi.org/10.1371/journal.pone.0098440
Volume	9
WOSCitedRecordID	wos000338631000017&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1fb9MwELdgA8QLsPJngVEZiQd4SIkdJ44f19GKam0VjYEKL5ET22LSlE79g4CPxQfhM3F2nEKnTYiXUxXbrXu-8_0uZ98h9JLFKZFMJyEnkoaM8DSULInCRJoSNkQFNtK4YhN8Os1mM5H_cRQvRfBjTt54nvYu5rXu2fSXjIGLvkvjNLVHuIb5uN15QXfT1F-Pu27klvlxWfptVtPz-fIqhHn5oORflmd4_3_n_ADd8xgTHzZCsYdu6LqDbjdVJ7930J2Jj6d30J5X7SV-5fNPv36IlqfudDjYNDwah-TXTyxr5T7yQ_x2YbdHPKoNiFJz7RE3Vx3ds7Wuf8jQ1gOptMKDb7KCZWteCuK5wT4VLx6vff_2Ox6hD8PB6dG70NdmCKtEpCvYRDO7xCqSUiVSKCqUAGRkZKVspBDcECqN1pWgXAMmTUtDU6mlqURW6TIy8WO0UwN39hGWKpOSUyM40cwAYqJlabg2JZEmEZoEKG6XrKh84nJbP-O8cNE4Dg5Mw9fCsrvw7A5QuBl10STu-Ef_vpWGTV-bdts9gHUtvBYXikdJGYmIa05tBFUYAMwx54CJCVVMBmjfylL7A8sC7EliA59MBOigla-rm19smkHBbdRG1nq-bvqkAJJjFqAnjThuJgm-M3jolAeIbwnq1r_YbqnPvrgk4sxewubR0-tn_AzdBXTI7Lk4Qg7Qzmqx1s_Rrerr6my56KKb_OSjpTPuaAY0OyJdtNsfTPOTrnu50XX6CfS43wM6iY4t5bmj74HmyWcYkY8m-affwhI8JQ
linkProvider	Public Library of Science
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFD4a4_oCrFxWGGAkkOAhW-w4cf2A0GCbVq2rEOrQ3oIT2zBpSkrTAuNH8cAP4TdxnDhlRRM87YG3KHYTx_3OzecG8IRHCVXcxIGgigWciiRQPA6DWNkMGaJGGWnrZhNiOOwdHso3S_C9zYVxYZUtT6wZtS5zd0a-gZQZOxcSly_HnwLXNcp5V9sWGg0s9szJFzTZqhf9Lfx_nzK2sz16vRv4rgJBHstkiuTfc4vToVI6VlIzqSXKdKty7XxcqEAzZY3JJRMGtakksyxRRtlc9nKThTbC516Ai8jHqQshE2_ftZwfeUeS-PS8SNANj4b1cVmYdVe4k7sjllPir-4S4KqqHpfVWRrun4GapyTfzo3_bc9uwnWvY5PNhihWYMkUHbjcdN086cCVfR9P0IEVz9oq8szX335-C6pRHR2PMp30BwH9-YOoQteXYpNsTZx4IP3CIik1aZ-kSfWs781M8U0Frh9KbjTZ_qpyhG1zKEpKS3wpYjKY-fntM27DwbnsyB1YLhAXq0CU7iklmJWCGm5RY2RZZoWxGVU2loZ2IWohk-a-cLvrH3Kc1t5IgQZcs6-pA1rqgdaFYP6rcVO45B_zXzk0zue6suP1jXLyIfVcLNUijLNQhsII5jzI0qLBEAmBNgFlmqsurDosty-o0t8I7MJai9Gzhx_Ph5HBOa-VKkw5a-YkaCREvAt3G3KYL5JxJELORBfEAqEsfMXiSHH0sS6izl0Sugjv_X1Zj-Dq7mh_kA76w737cA21Ze7iBCldg-XpZGYewKX88_SomjysOQGB9-dNRr8AgcShxg
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Nb9MwGH41BkxcgJWPBQYYCSQ4ZI0dJ64PCI11FdXKtMOQdsuc2IZJU1L6AYyfxZEfwW_ideKUFU1w2oFbFLuJ4z7vl98vgGc8TqniJgkFVSzkVKSh4kkUJsrmyBA1ykhbN5sQ-_u9oyN5sAI_2lwYF1bZ8sSaUeuqcGfkXaTMxLmQuOxaHxZx0B-8Hn8KXQcp52lt22k0ENkzZ1_QfJu-Gvbxv37O2GD3cOdt6DsMhEUi0xmygp5bqI6U0omSmkktUb5bVWjn70JlmilrTCGZMKhZpbllqTLKFrJXmDyyMT73ClwVMaLYZanvLMJLkI-kqU_ViwXtemRsjavSbLkintwdt5wThXXHAFdh9bSaXqTt_hm0eU4KDm79z_t3G2563ZtsN8SyDium7MD1phvnWQfW3vk4gw6se5Y3JS98Xe6Xd2B6WEfNo6wnw1FIf34nqtT1pdgm_YkTG2RYWiSxJh2UNCmg9b25Kb-p0PVJKYwmu19VgXBuDktJZYkvUUxGcz-_fcZdeH8pO3IPVkvEyAYQpXtKCWaloIZb1CRZnlthbE6VTaShAcQtfLLCF3R3fUVOs9pLKdCwa_Y1c6DLPOgCCBe_GjcFTf4x_41D5mKuK0de36gmHzLP3TItoiSPZCSMYM6zLC0aErEQaCtQprkKYMPhun3BNPuNxgA2W7xePPx0MYyMz3mzVGmqeTMnReMh5gHcb0hjsUjGJe1xJgIQS0Sz9BXLI-XJx7q4OnfJ6SJ68PdlPYE1pJ5sNNzfewg3UInmLnyQ0k1YnU3m5hFcKz7PTqaTxzVTIHB82VT0C_1EqiE
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Targeting+IL-1%CE%B2+and+IL-17A+Driven+Inflammation+during+Influenza-Induced+Exacerbations+of+Chronic+Lung+Inflammation&rft.jtitle=PloS+one&rft.au=Sichelstiel%2C+Anke&rft.au=Yadava%2C+Koshika&rft.au=Trompette%2C+Aur%C3%A9lien&rft.au=Salami%2C+Olawale&rft.date=2014-06-11&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=9&rft.issue=6&rft.spage=e98440&rft_id=info:doi/10.1371%2Fjournal.pone.0098440&rft.externalDBID=n%2Fa&rft.externalDocID=10_1371_journal_pone_0098440
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon