A mitochondrial root to accelerated ageing and frailty

A discovery metabolomic study was performed in a large cohort of adults to identify circulating biomarkers of frailty. The study found that carnitine and vitamin E pathways were dysregulated in frail compared with non-frail participants. These findings point to dysregulated mitochondrial metabolism...

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Published in:Nature reviews. Endocrinology Vol. 16; no. 3; pp. 133 - 134
Main Authors: Ferrucci, Luigi, Zampino, Marta
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.03.2020
Subjects:
Aging
Biomarkers - metabolism
Carnitine
Carnitine - metabolism
Frailty
Humans
Metabolomics
Mitochondria
Mitochondria - metabolism
Vitamin E
Vitamin E - metabolism
ISSN:1759-5029, 1759-5037, 1759-5037
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Abstract A discovery metabolomic study was performed in a large cohort of adults to identify circulating biomarkers of frailty. The study found that carnitine and vitamin E pathways were dysregulated in frail compared with non-frail participants. These findings point to dysregulated mitochondrial metabolism as a potential root of age-related frailty.
AbstractList A discovery metabolomic study was performed in a large cohort of adults to identify circulating biomarkers of frailty. The study found that carnitine and vitamin E pathways were dysregulated in frail compared with non-frail participants. These findings point to dysregulated mitochondrial metabolism as a potential root of age-related frailty.
Author Zampino, Marta
Ferrucci, Luigi
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  fullname: Ferrucci, Luigi
  email: ferruccilu@grc.nia.nih.gov
  organization: National Institute on Aging, National Institute of Health, Baltimore, MD, USA. ferruccilu@grc.nia.nih.gov
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  givenname: Marta
  surname: Zampino
  fullname: Zampino, Marta
  organization: National Institute on Aging, National Institute of Health, Baltimore, MD, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31992872$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2020© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply. 2020
This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply. 2020.
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SubjectTerms Aging
Biomarkers - metabolism
Carnitine
Carnitine - metabolism
Frailty
Humans
Metabolomics
Mitochondria
Mitochondria - metabolism
Vitamin E
Vitamin E - metabolism
Title A mitochondrial root to accelerated ageing and frailty
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