Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia

Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 a...

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Published in:Placenta (Eastbourne) Vol. 36; no. 5; pp. 607 - 610
Main Authors: Smith-Jackson, K., Hentschke, M.R., Poli-de-Figueiredo, C.E., Pinheiro da Costa, B.E., Kurlak, L.O., Broughton Pipkin, F., Czajka, A., Mistry, H.D.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.05.2015
Subjects:
Case-Control Studies
Caveolae - metabolism
Caveolin
Caveolin 1 - metabolism
Cavin
Female
Humans
Hypertension
Internal Medicine
Nitric Oxide Synthase Type II - metabolism
Nitric Oxide Synthase Type III - metabolism
Obstetrics and Gynecology
Placenta
Placenta - metabolism
Pre-eclampsia
Pre-Eclampsia - metabolism
Pregnancy
Hypertension
Cavin
Placenta
Pre-eclampsia
Caveolin
ISSN:0143-4004, 1532-3102, 1532-3102
Online Access:Get full text
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Summary:Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation. •First report of all components of caveolae expression in human placentae tissue.•Caveolin-1, cavin-1, -2 & 3 mRNA expression was lower in pre-eclamptic placentae.•eNOS mRNA expression was increased in pre-eclamptic placentae.•Caveolin-1 protein expression was also reduced in pre-eclampsia.•Could be an adaptive response to attenuate the oxidative stress and inflammation.
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ISSN:0143-4004
1532-3102
1532-3102
DOI:10.1016/j.placenta.2015.02.001