Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia

Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 a...

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Veröffentlicht in:	Placenta (Eastbourne) Jg. 36; H. 5; S. 607 - 610
Hauptverfasser:	Smith-Jackson, K., Hentschke, M.R., Poli-de-Figueiredo, C.E., Pinheiro da Costa, B.E., Kurlak, L.O., Broughton Pipkin, F., Czajka, A., Mistry, H.D.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ltd 01.05.2015
Schlagworte:	Case-Control Studies Caveolae - metabolism Caveolin Caveolin 1 - metabolism Cavin Female Humans Hypertension Internal Medicine Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - metabolism Obstetrics and Gynecology Placenta Placenta - metabolism Pre-eclampsia Pre-Eclampsia - metabolism Pregnancy Hypertension Cavin Placenta Pre-eclampsia Caveolin
ISSN:	0143-4004, 1532-3102, 1532-3102
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Abstract	Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation. •First report of all components of caveolae expression in human placentae tissue.•Caveolin-1, cavin-1, -2 & 3 mRNA expression was lower in pre-eclamptic placentae.•eNOS mRNA expression was increased in pre-eclamptic placentae.•Caveolin-1 protein expression was also reduced in pre-eclampsia.•Could be an adaptive response to attenuate the oxidative stress and inflammation.
AbstractList	Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation. •First report of all components of caveolae expression in human placentae tissue.•Caveolin-1, cavin-1, -2 & 3 mRNA expression was lower in pre-eclamptic placentae.•eNOS mRNA expression was increased in pre-eclamptic placentae.•Caveolin-1 protein expression was also reduced in pre-eclampsia.•Could be an adaptive response to attenuate the oxidative stress and inflammation. Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation. AbstractCaveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia ( P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia ( P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation. Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.
Author	Hentschke, M.R. Broughton Pipkin, F. Mistry, H.D. Czajka, A. Pinheiro da Costa, B.E. Smith-Jackson, K. Poli-de-Figueiredo, C.E. Kurlak, L.O.
Author_xml	– sequence: 1 givenname: K. surname: Smith-Jackson fullname: Smith-Jackson, K. organization: Division of Women's Health, King's College London, Women's Health Academic Centre, UK – sequence: 2 givenname: M.R. surname: Hentschke fullname: Hentschke, M.R. organization: Division of Women's Health, King's College London, Women's Health Academic Centre, UK – sequence: 3 givenname: C.E. surname: Poli-de-Figueiredo fullname: Poli-de-Figueiredo, C.E. organization: Laboratory of Nephrology – IPB, School of Medicine, PUCRS, Brazil – sequence: 4 givenname: B.E. surname: Pinheiro da Costa fullname: Pinheiro da Costa, B.E. organization: Laboratory of Nephrology – IPB, School of Medicine, PUCRS, Brazil – sequence: 5 givenname: L.O. surname: Kurlak fullname: Kurlak, L.O. organization: Department of Obstetrics & Gynaecology, School of Medicine, University of Nottingham, UK – sequence: 6 givenname: F. surname: Broughton Pipkin fullname: Broughton Pipkin, F. organization: Department of Obstetrics & Gynaecology, School of Medicine, University of Nottingham, UK – sequence: 7 givenname: A. surname: Czajka fullname: Czajka, A. organization: Division of Diabetes and Nutritional Sciences, Diabetes Research Group, King's College London, UK – sequence: 8 givenname: H.D. surname: Mistry fullname: Mistry, H.D. email: hiten.mistry@kcl.ac.uk organization: Division of Women's Health, King's College London, Women's Health Academic Centre, UK
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Cites_doi	10.1161/ATVBAHA.111.230623 10.1016/j.biochi.2010.03.022 10.1053/plac.2001.0697 10.1161/01.ATV.0000101182.89118.E5 10.1016/j.placenta.2012.11.027 10.1016/S0955-0674(96)80033-0 10.1385/ENDO:29:3:491 10.1161/01.HYP.0000242907.70697.5d 10.1042/bj3570593 10.1053/plac.2002.0847 10.1016/j.placenta.2010.02.014 10.1161/HYPERTENSIONAHA.108.116103 10.1016/S0301-2115(00)00532-7 10.1053/plac.2001.0718 10.1155/2011/573432 10.1016/j.jnutbio.2010.09.013 10.1016/S0143-4004(03)00106-1 10.1161/HYPERTENSIONAHA.111.173740 10.3109/10641950109152635 10.1016/0002-9378(95)90324-0 10.1074/jbc.M707890200 10.1016/j.freeradbiomed.2014.04.029
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Snippet	Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by... AbstractCaveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised...
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SubjectTerms	Case-Control Studies Caveolae - metabolism Caveolin Caveolin 1 - metabolism Cavin Female Humans Hypertension Internal Medicine Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - metabolism Obstetrics and Gynecology Placenta Placenta - metabolism Pre-eclampsia Pre-Eclampsia - metabolism Pregnancy
Title	Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia
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