Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

Impaired mitochondrial respiratory activity contributes to the development of insulin resistance in type 2 diabetes. Metformin, a first-line antidiabetic drug, functions mainly by improving patients’ hyperglycemia and insulin resistance. However, its mechanism of action is still not well understood....

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 29; no. 6; pp. 1511 - 1523.e5
Main Authors:	Wang, Yu, An, Hongying, Liu, Ting, Qin, Caolitao, Sesaki, Hiromi, Guo, Shaodong, Radovick, Sally, Hussain, Mehboob, Maheshwari, Akhil, Wondisford, Fredric E., O’Rourke, Brian, He, Ling
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 05.11.2019 Elsevier
Subjects:	adenine nucleotides Adenine Nucleotides - metabolism AMP-Activated Protein Kinase Kinases AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism AMPK Animals Blood Glucose - metabolism Cell Respiration - drug effects Cell Respiration - genetics diabetes Diet, High-Fat Drp1 Electron Transport Complex I - drug effects Electron Transport Complex I - metabolism Gene Knockout Techniques Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - ultrastructure Hyperglycemia - drug therapy Hyperglycemia - genetics Hyperglycemia - metabolism Hypoglycemic Agents - pharmacology Insulin Resistance Liver - drug effects Liver - metabolism Liver - physiopathology Liver - ultrastructure membrane potential metformin Metformin - analysis Metformin - pharmacology Mice Mice, Inbred C57BL Mitochondria, Liver - drug effects Mitochondria, Liver - genetics Mitochondria, Liver - metabolism Mitochondria, Liver - ultrastructure Mitochondrial Dynamics - drug effects mitochondrial respiration/fission Protein Kinases - genetics Protein Kinases - metabolism membrane potential metformin AMPK mitochondrial respiration/fission adenine nucleotides diabetes insulin resistance Drp1
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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