The Cancer SENESCopedia: A delineation of cancer cell senescence

Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells. However, senescence features may be different in cancer cells, since the pathways that are involved in sen...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 36; no. 4; p. 109441
Main Authors:	Jochems, Fleur, Thijssen, Bram, De Conti, Giulia, Jansen, Robin, Pogacar, Ziva, Groot, Kelvin, Wang, Liqin, Schepers, Arnout, Wang, Cun, Jin, Haojie, Beijersbergen, Roderick L., Leite de Oliveira, Rodrigo, Wessels, Lodewyk F.A., Bernards, René
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 27.07.2021 Cell Press Elsevier
Subjects:	ABT-263 Aniline Compounds - pharmacology Azepines - pharmacology cancer cell cycle Cell Line, Tumor Cellular Senescence - drug effects Etoposide - pharmacology gene expression classifier Gene Expression Regulation, Neoplastic - drug effects Humans Neoplasms - genetics Neoplasms - pathology Pyrimidines - pharmacology Reproducibility of Results Resource SASP SENCAN senescence Senescence-Associated Secretory Phenotype - drug effects Senescence-Associated Secretory Phenotype - genetics SENESCopedia senolytics Senotherapeutics - pharmacology Sulfonamides - pharmacology transcriptome profiling senescence SENESCopedia cell cycle SENCAN transcriptome profiling senolytics cancer ABT-263 SASP gene expression classifier
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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