Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

The ability to maintain quiescence is critical for the long-term maintenance of a functional stem cell pool. To date, the epigenetic and transcriptional characteristics of quiescent stem cells and how they change with age remain largely unknown. In this study, we explore the chromatin features of ad...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 4; H. 1; S. 189 - 204
Hauptverfasser:	Liu, Ling, Cheung, Tom H., Charville, Gregory W., Hurgo, Bernadette Marie Ceniza, Leavitt, Tripp, Shih, Johnathan, Brunet, Anne, Rando, Thomas A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 11.07.2013 Elsevier
Schlagworte:	Adult Stem Cells - cytology Adult Stem Cells - metabolism Animals Cellular Senescence Chromatin - metabolism Epigenesis, Genetic Gene Expression Regulation, Developmental Histones - genetics Histones - metabolism Methylation Mice Muscle Development Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - metabolism Polycomb-Group Proteins - chemistry Polycomb-Group Proteins - genetics Polycomb-Group Proteins - metabolism Protein Processing, Post-Translational Protein Structure, Tertiary Transcription Initiation Site Transcription, Genetic
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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