Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

The ability to maintain quiescence is critical for the long-term maintenance of a functional stem cell pool. To date, the epigenetic and transcriptional characteristics of quiescent stem cells and how they change with age remain largely unknown. In this study, we explore the chromatin features of ad...

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Vydáno v:	Cell reports (Cambridge) Ročník 4; číslo 1; s. 189 - 204
Hlavní autoři:	Liu, Ling, Cheung, Tom H., Charville, Gregory W., Hurgo, Bernadette Marie Ceniza, Leavitt, Tripp, Shih, Johnathan, Brunet, Anne, Rando, Thomas A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 11.07.2013 Elsevier
Témata:	Adult Stem Cells - cytology Adult Stem Cells - metabolism Animals Cellular Senescence Chromatin - metabolism Epigenesis, Genetic Gene Expression Regulation, Developmental Histones - genetics Histones - metabolism Methylation Mice Muscle Development Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - metabolism Polycomb-Group Proteins - chemistry Polycomb-Group Proteins - genetics Polycomb-Group Proteins - metabolism Protein Processing, Post-Translational Protein Structure, Tertiary Transcription Initiation Site Transcription, Genetic
ISSN:	2211-1247, 2211-1247
On-line přístup:	Získat plný text
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