Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions

Embryonic stem cells (ESCs) are derived from mammalian embryos during the transition from totipotency, when individual blastomeres can make all lineages, to pluripotency, when they are competent to make only embryonic lineages. ESCs maintained with inhibitors of MEK and GSK3 (2i) are thought to repr...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 3; H. 6; S. 1945 - 1957
Hauptverfasser:	Morgani, Sophie M., Canham, Maurice A., Nichols, Jennifer, Sharov, Alexei A., Migueles, Rosa Portero, Ko, Minoru S.H., Brickman, Joshua M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 27.06.2013 Cell Press Elsevier
Schlagworte:	Animals Cell Differentiation - physiology Cells, Cultured Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Female Humans Mice Mice, Inbred C57BL Mice, Transgenic Pseudopregnancy Totipotent Stem Cells - cytology Totipotent Stem Cells - metabolism
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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