Nosocomial transmission, adaption and clinical outcomes of carbapenem-resistant hypervirulent Klebsiella pneumoniae

Background Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial transmission dynamics, adaptive phenotypes, and clinical outcomes of CR-HvKp with different evolutionary patterns. Methods A genom...

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Bibliographic Details
Published in:	BMC microbiology Vol. 25; no. 1; pp. 376 - 15
Main Authors:	Liu, Yanjun, Wang, Zhiqian, Jian, Zijuan, Liu, Peilin, Li, Yanming, Qin, Fang, Yan, Qun, Liu, Wenen
Format:	Journal Article
Language:	English
Published:	London BioMed Central 02.07.2025 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adaptation Aged Anti-Bacterial Agents - pharmacology Antibiotics Antigens Antimicrobial agents Bacteria Biofilms Biological Microscopy Biomedical and Life Sciences Carbapenem-Resistant Enterobacteriaceae - drug effects Carbapenem-Resistant Enterobacteriaceae - genetics Carbapenem-Resistant Enterobacteriaceae - isolation & purification Carbapenem-Resistant Enterobacteriaceae - pathogenicity Carbapenem-resistant hypervirulent Klebsiella pneumoniae Carbapenems Carbapenems - pharmacology Care and treatment China - epidemiology Clinical outcomes Competitiveness Control Cross infection Cross Infection - epidemiology Cross Infection - microbiology Cross Infection - transmission Diagnosis Disease transmission Drug resistance Electronic health records Electronic medical records Epidemiology Evolution & development Evolutionary patterns Female Genes Genomes Genomic analysis Hospitals Humans Identification and classification Infections Intensive Care Units Klebsiella Klebsiella Infections - drug therapy Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella Infections - mortality Klebsiella Infections - transmission Klebsiella pneumoniae Klebsiella pneumoniae - classification Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Klebsiella pneumoniae - pathogenicity Laboratory animals Life Sciences Male Maximum likelihood method Microbial Sensitivity Tests Microbiology Middle Aged Mortality Mycology Neutrophils Nosocomial infection Nosocomial infections Nosocomial transmission Parasitology Phenotypes Phylogenetics Plasmids Prevention Retrospective Studies Risk factors Sepsis Septic shock Virology Virulence China Nosocomial transmission Carbapenem-resistant hypervirulent Evolutionary patterns Clinical outcomes Adaptation Carbapenem-resistant hypervirulent Klebsiella pneumoniae
ISSN:	1471-2180, 1471-2180
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