Nosocomial transmission, adaption and clinical outcomes of carbapenem-resistant hypervirulent Klebsiella pneumoniae
Background Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial transmission dynamics, adaptive phenotypes, and clinical outcomes of CR-HvKp with different evolutionary patterns. Methods A genom...
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| Vydané v: | BMC microbiology Ročník 25; číslo 1; s. 376 - 15 |
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| Hlavní autori: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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BioMed Central
02.07.2025
BioMed Central Ltd Springer Nature B.V BMC |
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| Abstract | Background
Carbapenem-resistant hypervirulent
Klebsiella pneumoniae
(CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial transmission dynamics, adaptive phenotypes, and clinical outcomes of CR-HvKp with different evolutionary patterns.
Methods
A genomic analysis of 2,002
Klebsiella pneumoniae
isolates collected from a major teaching hospital in China was performed to identify convergent isolates. Epidemiological features, including CR-HvKp nosocomial transmission, were assessed. Selected isolates underwent phenotypic testing to evaluate adaptive traits. Clinical outcomes were analyzed retrospectively using electronic medical records.
Results
A total of 127 CR-HvKp were characterized, with ST11-KL64 hv-CRKP (carbapenem resistant
Klebsiella pneumoniae
acquired hypervirulence) as the predominant sequence type. CR-HvKp exhibited diverse evolutionary patterns linked to nosocomial transmission, particularly in the ICU. ST11-KL64 hv-CRKP demonstrated robust transmission within ICU settings. Compared to CRKP, hv-CRKP showed enhanced in vitro competitiveness and superior immune evasion. CR-HvKp infections were significantly associated with higher mortality rates, especially involved in sepsis or septic shock (
P
< 0.0001).
Conclusion
The ST11-KL64 hv-CRKP clonal complex is highly prevalent in CR-HvKp and demonstrates significant nosocomial transmission, particularly within ICU settings. Timely and effective sepsis management is critical to improving survival outcomes in CR-HvKp infections. Continuous genomic surveillance is imperative to control the spread of these pathogens. |
|---|---|
| AbstractList | Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial transmission dynamics, adaptive phenotypes, and clinical outcomes of CR-HvKp with different evolutionary patterns.
A genomic analysis of 2,002 Klebsiella pneumoniae isolates collected from a major teaching hospital in China was performed to identify convergent isolates. Epidemiological features, including CR-HvKp nosocomial transmission, were assessed. Selected isolates underwent phenotypic testing to evaluate adaptive traits. Clinical outcomes were analyzed retrospectively using electronic medical records.
A total of 127 CR-HvKp were characterized, with ST11-KL64 hv-CRKP (carbapenem resistant Klebsiella pneumoniae acquired hypervirulence) as the predominant sequence type. CR-HvKp exhibited diverse evolutionary patterns linked to nosocomial transmission, particularly in the ICU. ST11-KL64 hv-CRKP demonstrated robust transmission within ICU settings. Compared to CRKP, hv-CRKP showed enhanced in vitro competitiveness and superior immune evasion. CR-HvKp infections were significantly associated with higher mortality rates, especially involved in sepsis or septic shock (P < 0.0001).
The ST11-KL64 hv-CRKP clonal complex is highly prevalent in CR-HvKp and demonstrates significant nosocomial transmission, particularly within ICU settings. Timely and effective sepsis management is critical to improving survival outcomes in CR-HvKp infections. Continuous genomic surveillance is imperative to control the spread of these pathogens. Background Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial transmission dynamics, adaptive phenotypes, and clinical outcomes of CR-HvKp with different evolutionary patterns. Methods A genomic analysis of 2,002 Klebsiella pneumoniae isolates collected from a major teaching hospital in China was performed to identify convergent isolates. Epidemiological features, including CR-HvKp nosocomial transmission, were assessed. Selected isolates underwent phenotypic testing to evaluate adaptive traits. Clinical outcomes were analyzed retrospectively using electronic medical records. Results A total of 127 CR-HvKp were characterized, with ST11-KL64 hv-CRKP (carbapenem resistant Klebsiella pneumoniae acquired hypervirulence) as the predominant sequence type. CR-HvKp exhibited diverse evolutionary patterns linked to nosocomial transmission, particularly in the ICU. ST11-KL64 hv-CRKP demonstrated robust transmission within ICU settings. Compared to CRKP, hv-CRKP showed enhanced in vitro competitiveness and superior immune evasion. CR-HvKp infections were significantly associated with higher mortality rates, especially involved in sepsis or septic shock (P < 0.0001). Conclusion The ST11-KL64 hv-CRKP clonal complex is highly prevalent in CR-HvKp and demonstrates significant nosocomial transmission, particularly within ICU settings. Timely and effective sepsis management is critical to improving survival outcomes in CR-HvKp infections. Continuous genomic surveillance is imperative to control the spread of these pathogens. Keywords: Carbapenem-resistant hypervirulent Klebsiella pneumoniae, Evolutionary patterns, Nosocomial transmission, Adaptation, Clinical outcomes Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial transmission dynamics, adaptive phenotypes, and clinical outcomes of CR-HvKp with different evolutionary patterns. A genomic analysis of 2,002 Klebsiella pneumoniae isolates collected from a major teaching hospital in China was performed to identify convergent isolates. Epidemiological features, including CR-HvKp nosocomial transmission, were assessed. Selected isolates underwent phenotypic testing to evaluate adaptive traits. Clinical outcomes were analyzed retrospectively using electronic medical records. A total of 127 CR-HvKp were characterized, with ST11-KL64 hv-CRKP (carbapenem resistant Klebsiella pneumoniae acquired hypervirulence) as the predominant sequence type. CR-HvKp exhibited diverse evolutionary patterns linked to nosocomial transmission, particularly in the ICU. ST11-KL64 hv-CRKP demonstrated robust transmission within ICU settings. Compared to CRKP, hv-CRKP showed enhanced in vitro competitiveness and superior immune evasion. CR-HvKp infections were significantly associated with higher mortality rates, especially involved in sepsis or septic shock (P < 0.0001). The ST11-KL64 hv-CRKP clonal complex is highly prevalent in CR-HvKp and demonstrates significant nosocomial transmission, particularly within ICU settings. Timely and effective sepsis management is critical to improving survival outcomes in CR-HvKp infections. Continuous genomic surveillance is imperative to control the spread of these pathogens. BackgroundCarbapenem-resistant hypervirulent Klebsiella pneumoniae(CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial transmission dynamics, adaptive phenotypes, and clinical outcomes of CR-HvKp with different evolutionary patterns.MethodsA genomic analysis of 2,002 Klebsiella pneumoniaeisolates collected from a major teaching hospital in China was performed to identify convergent isolates. Epidemiological features, including CR-HvKp nosocomial transmission, were assessed. Selected isolates underwent phenotypic testing to evaluate adaptive traits. Clinical outcomes were analyzed retrospectively using electronic medical records.ResultsA total of 127 CR-HvKp were characterized, with ST11-KL64 hv-CRKP (carbapenem resistant Klebsiella pneumoniaeacquired hypervirulence) as the predominant sequence type. CR-HvKp exhibited diverse evolutionary patterns linked to nosocomial transmission, particularly in the ICU. ST11-KL64 hv-CRKP demonstrated robust transmission within ICU settings. Compared to CRKP, hv-CRKP showed enhanced in vitro competitiveness and superior immune evasion. CR-HvKp infections were significantly associated with higher mortality rates, especially involved in sepsis or septic shock (P < 0.0001).ConclusionThe ST11-KL64 hv-CRKP clonal complex is highly prevalent in CR-HvKp and demonstrates significant nosocomial transmission, particularly within ICU settings. Timely and effective sepsis management is critical to improving survival outcomes in CR-HvKp infections. Continuous genomic surveillance is imperative to control the spread of these pathogens. Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial transmission dynamics, adaptive phenotypes, and clinical outcomes of CR-HvKp with different evolutionary patterns.BACKGROUNDCarbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial transmission dynamics, adaptive phenotypes, and clinical outcomes of CR-HvKp with different evolutionary patterns.A genomic analysis of 2,002 Klebsiella pneumoniae isolates collected from a major teaching hospital in China was performed to identify convergent isolates. Epidemiological features, including CR-HvKp nosocomial transmission, were assessed. Selected isolates underwent phenotypic testing to evaluate adaptive traits. Clinical outcomes were analyzed retrospectively using electronic medical records.METHODSA genomic analysis of 2,002 Klebsiella pneumoniae isolates collected from a major teaching hospital in China was performed to identify convergent isolates. Epidemiological features, including CR-HvKp nosocomial transmission, were assessed. Selected isolates underwent phenotypic testing to evaluate adaptive traits. Clinical outcomes were analyzed retrospectively using electronic medical records.A total of 127 CR-HvKp were characterized, with ST11-KL64 hv-CRKP (carbapenem resistant Klebsiella pneumoniae acquired hypervirulence) as the predominant sequence type. CR-HvKp exhibited diverse evolutionary patterns linked to nosocomial transmission, particularly in the ICU. ST11-KL64 hv-CRKP demonstrated robust transmission within ICU settings. Compared to CRKP, hv-CRKP showed enhanced in vitro competitiveness and superior immune evasion. CR-HvKp infections were significantly associated with higher mortality rates, especially involved in sepsis or septic shock (P < 0.0001).RESULTSA total of 127 CR-HvKp were characterized, with ST11-KL64 hv-CRKP (carbapenem resistant Klebsiella pneumoniae acquired hypervirulence) as the predominant sequence type. CR-HvKp exhibited diverse evolutionary patterns linked to nosocomial transmission, particularly in the ICU. ST11-KL64 hv-CRKP demonstrated robust transmission within ICU settings. Compared to CRKP, hv-CRKP showed enhanced in vitro competitiveness and superior immune evasion. CR-HvKp infections were significantly associated with higher mortality rates, especially involved in sepsis or septic shock (P < 0.0001).The ST11-KL64 hv-CRKP clonal complex is highly prevalent in CR-HvKp and demonstrates significant nosocomial transmission, particularly within ICU settings. Timely and effective sepsis management is critical to improving survival outcomes in CR-HvKp infections. Continuous genomic surveillance is imperative to control the spread of these pathogens.CONCLUSIONThe ST11-KL64 hv-CRKP clonal complex is highly prevalent in CR-HvKp and demonstrates significant nosocomial transmission, particularly within ICU settings. Timely and effective sepsis management is critical to improving survival outcomes in CR-HvKp infections. Continuous genomic surveillance is imperative to control the spread of these pathogens. Background Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial transmission dynamics, adaptive phenotypes, and clinical outcomes of CR-HvKp with different evolutionary patterns. Methods A genomic analysis of 2,002 Klebsiella pneumoniae isolates collected from a major teaching hospital in China was performed to identify convergent isolates. Epidemiological features, including CR-HvKp nosocomial transmission, were assessed. Selected isolates underwent phenotypic testing to evaluate adaptive traits. Clinical outcomes were analyzed retrospectively using electronic medical records. Results A total of 127 CR-HvKp were characterized, with ST11-KL64 hv-CRKP (carbapenem resistant Klebsiella pneumoniae acquired hypervirulence) as the predominant sequence type. CR-HvKp exhibited diverse evolutionary patterns linked to nosocomial transmission, particularly in the ICU. ST11-KL64 hv-CRKP demonstrated robust transmission within ICU settings. Compared to CRKP, hv-CRKP showed enhanced in vitro competitiveness and superior immune evasion. CR-HvKp infections were significantly associated with higher mortality rates, especially involved in sepsis or septic shock ( P < 0.0001). Conclusion The ST11-KL64 hv-CRKP clonal complex is highly prevalent in CR-HvKp and demonstrates significant nosocomial transmission, particularly within ICU settings. Timely and effective sepsis management is critical to improving survival outcomes in CR-HvKp infections. Continuous genomic surveillance is imperative to control the spread of these pathogens. Abstract Background Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial transmission dynamics, adaptive phenotypes, and clinical outcomes of CR-HvKp with different evolutionary patterns. Methods A genomic analysis of 2,002 Klebsiella pneumoniae isolates collected from a major teaching hospital in China was performed to identify convergent isolates. Epidemiological features, including CR-HvKp nosocomial transmission, were assessed. Selected isolates underwent phenotypic testing to evaluate adaptive traits. Clinical outcomes were analyzed retrospectively using electronic medical records. Results A total of 127 CR-HvKp were characterized, with ST11-KL64 hv-CRKP (carbapenem resistant Klebsiella pneumoniae acquired hypervirulence) as the predominant sequence type. CR-HvKp exhibited diverse evolutionary patterns linked to nosocomial transmission, particularly in the ICU. ST11-KL64 hv-CRKP demonstrated robust transmission within ICU settings. Compared to CRKP, hv-CRKP showed enhanced in vitro competitiveness and superior immune evasion. CR-HvKp infections were significantly associated with higher mortality rates, especially involved in sepsis or septic shock (P < 0.0001). Conclusion The ST11-KL64 hv-CRKP clonal complex is highly prevalent in CR-HvKp and demonstrates significant nosocomial transmission, particularly within ICU settings. Timely and effective sepsis management is critical to improving survival outcomes in CR-HvKp infections. Continuous genomic surveillance is imperative to control the spread of these pathogens. |
| ArticleNumber | 376 |
| Audience | Academic |
| Author | Liu, Wenen Liu, Peilin Li, Yanming Yan, Qun Qin, Fang Liu, Yanjun Jian, Zijuan Wang, Zhiqian |
| Author_xml | – sequence: 1 givenname: Yanjun surname: Liu fullname: Liu, Yanjun organization: Department of Clinical Laboratory, Xiangya Hospital, Central South University – sequence: 2 givenname: Zhiqian surname: Wang fullname: Wang, Zhiqian organization: Department of Clinical Laboratory, Xiangya Hospital, Central South University – sequence: 3 givenname: Zijuan surname: Jian fullname: Jian, Zijuan organization: Department of Clinical Laboratory, Xiangya Hospital, Central South University – sequence: 4 givenname: Peilin surname: Liu fullname: Liu, Peilin organization: Department of Clinical Laboratory, Xiangya Hospital, Central South University – sequence: 5 givenname: Yanming surname: Li fullname: Li, Yanming organization: Department of Clinical Laboratory, Xiangya Hospital, Central South University – sequence: 6 givenname: Fang surname: Qin fullname: Qin, Fang organization: Department of Clinical Laboratory, Xiangya Hospital, Central South University – sequence: 7 givenname: Qun surname: Yan fullname: Yan, Qun organization: Department of Clinical Laboratory, Xiangya Hospital, Central South University – sequence: 8 givenname: Wenen surname: Liu fullname: Liu, Wenen email: wenenliu@163.com organization: Department of Clinical Laboratory, Xiangya Hospital, Central South University, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital |
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| Keywords | Nosocomial transmission Carbapenem-resistant hypervirulent Evolutionary patterns Clinical outcomes Adaptation Carbapenem-resistant hypervirulent Klebsiella pneumoniae |
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| Snippet | Background
Carbapenem-resistant hypervirulent
Klebsiella pneumoniae
(CR-HvKp) poses a significant threat in healthcare settings. This study investigates the... Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial... Background Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the... BackgroundCarbapenem-resistant hypervirulent Klebsiella pneumoniae(CR-HvKp) poses a significant threat in healthcare settings. This study investigates the... Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial... Abstract Background Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study... |
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| SubjectTerms | Adaptation Aged Anti-Bacterial Agents - pharmacology Antibiotics Antigens Antimicrobial agents Bacteria Biofilms Biological Microscopy Biomedical and Life Sciences Carbapenem-Resistant Enterobacteriaceae - drug effects Carbapenem-Resistant Enterobacteriaceae - genetics Carbapenem-Resistant Enterobacteriaceae - isolation & purification Carbapenem-Resistant Enterobacteriaceae - pathogenicity Carbapenem-resistant hypervirulent Klebsiella pneumoniae Carbapenems Carbapenems - pharmacology Care and treatment China - epidemiology Clinical outcomes Competitiveness Control Cross infection Cross Infection - epidemiology Cross Infection - microbiology Cross Infection - transmission Diagnosis Disease transmission Drug resistance Electronic health records Electronic medical records Epidemiology Evolution & development Evolutionary patterns Female Genes Genomes Genomic analysis Hospitals Humans Identification and classification Infections Intensive Care Units Klebsiella Klebsiella Infections - drug therapy Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella Infections - mortality Klebsiella Infections - transmission Klebsiella pneumoniae Klebsiella pneumoniae - classification Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Klebsiella pneumoniae - pathogenicity Laboratory animals Life Sciences Male Maximum likelihood method Microbial Sensitivity Tests Microbiology Middle Aged Mortality Mycology Neutrophils Nosocomial infection Nosocomial infections Nosocomial transmission Parasitology Phenotypes Phylogenetics Plasmids Prevention Retrospective Studies Risk factors Sepsis Septic shock Virology Virulence |
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| Title | Nosocomial transmission, adaption and clinical outcomes of carbapenem-resistant hypervirulent Klebsiella pneumoniae |
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