Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling

RIF1 is a multifunctional protein implicated in controlling DNA replication and repair. Here, we show that human RIF1 protects nascent DNA from over-degradation at stalled replication forks. The major nuclease resecting nascent DNA in the absence of RIF1 is DNA2, operating with WRN as an accessory h...

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Vydané v:	Cell reports (Cambridge) Ročník 27; číslo 9; s. 2558 - 2566.e4
Hlavní autori:	Garzón, Javier, Ursich, Sebastian, Lopes, Massimo, Hiraga, Shin-ichiro, Donaldson, Anne D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 28.05.2019 Cell Press Elsevier
Predmet:	DNA - chemistry DNA - genetics DNA - metabolism DNA Replication DNA2 fork protection genome integrity Genomic Instability HEK293 Cells Humans Phosphorylation Receptors, Neuropeptide Y - genetics Receptors, Neuropeptide Y - metabolism replication stress RIF1-PP1 Telomere-Binding Proteins - genetics Telomere-Binding Proteins - metabolism Werner Syndrome Helicase - genetics Werner Syndrome Helicase - metabolism WRN DNA replication replication stress WRN RIF1-PP1 DNA2 genome integrity fork protection
ISSN:	2211-1247, 2211-1247
On-line prístup:	Získať plný text
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