Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients

Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor, and no effective treatment is available to date. Mouse models of SCLC based on the inactivation of Rb1 and Trp53 show frequent amplifications of the Nfib and Mycl genes. Here, we report that, although overexpression of either trans...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 16; H. 3; S. 631 - 643
Hauptverfasser:	Semenova, Ekaterina A., Kwon, Min-chul, Monkhorst, Kim, Song, Ji-Ying, Bhaskaran, Rajith, Krijgsman, Oscar, Kuilman, Thomas, Peters, Dennis, Buikhuisen, Wieneke A., Smit, Egbert F., Pritchard, Colin, Cozijnsen, Miranda, van der Vliet, Jan, Zevenhoven, John, Lambooij, Jan-Paul, Proost, Natalie, van Montfort, Erwin, Velds, Arno, Huijbers, Ivo J., Berns, Anton
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 19.07.2016 Cell Press Elsevier
Schlagworte:	Animals Biomarkers, Tumor - metabolism Cadherins - metabolism Cell Proliferation - physiology Disease Models, Animal Disease Progression Gene Expression Regulation, Neoplastic - physiology Humans Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Neoplasm Metastasis - pathology NFI Transcription Factors - metabolism Proto-Oncogene Proteins c-myc - metabolism Retinoblastoma Protein - metabolism Small Cell Lung Carcinoma - metabolism Small Cell Lung Carcinoma - pathology Tumor Suppressor Protein p53 - metabolism
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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