Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease

•This is the first application of PCA to synaptic density PET in Alzheimer’s disease.•Principal components reflect spatial patterns of covariance in synaptic density.•Principal components are correlated with unique characteristics in Alzheimer’s disease.•These findings support synaptic density as a...

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Bibliographic Details
Published in:	NeuroImage clinical Vol. 39; p. 103457
Main Authors:	O'Dell, Ryan S., Higgins-Chen, Albert, Gupta, Dhruva, Chen, Ming-Kai, Naganawa, Mika, Toyonaga, Takuya, Lu, Yihuan, Ni, Gessica, Chupak, Anna, Zhao, Wenzhen, Salardini, Elaheh, Nabulsi, Nabeel B., Huang, Yiyun, Arnsten, Amy F.T., Carson, Richard E., van Dyck, Christopher H., Mecca, Adam P.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01.01.2023 Elsevier
Subjects:	[11C]UCB-J Alzheimer Disease - pathology Alzheimer’s disease Amyloid - metabolism Amyloidogenic Proteins - metabolism Brain - pathology Cognitive Dysfunction - pathology Humans Positron emission tomography Principal Component Analysis Radiology Regular SV2A Synaptic density DVR LMII MRI PiB Synaptic density CDR Aβ SD [11C]UCB-J SV2A MMSE GDS APOE BPND WAIS aMCI 1TC SRTM2 AD Alzheimer’s disease GM CN RAVLT ROI PCA CS IY PCC CDR-SB PC FWHM PVC Positron emission tomography PET VT Principal component analysis Cb V T principal component BP ND synaptic vesicle glycoprotein 2A full width half maximum Wechsler Adult Intelligence Scale Geriatric depression scale partial volume correction amyloid-β Iterative Yang apolipoprotein E Clinical Dementia Rating Scale Mini-Mental Status Exam [ 11C]UCB-J standard deviation magnetic resonance imaging cerebellum simplified reference tissue model – 2 step 1 tissue compartment Pittsburgh Compound B posterior cingulate cortex distribution volume ratio Rey Auditory Verbal Learning Test centrum semiovale CDR-sum of boxes Logical Memory II binding potential non-displaceable gray matter region of interest volume of distribution (total) cognitively normal amnestic mild cognitive impairment [C]UCB-J
ISSN:	2213-1582, 2213-1582
Online Access:	Get full text
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