Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease
•This is the first application of PCA to synaptic density PET in Alzheimer’s disease.•Principal components reflect spatial patterns of covariance in synaptic density.•Principal components are correlated with unique characteristics in Alzheimer’s disease.•These findings support synaptic density as a...
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| Published in: | NeuroImage clinical Vol. 39; p. 103457 |
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| ISSN: | 2213-1582, 2213-1582 |
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| Abstract | •This is the first application of PCA to synaptic density PET in Alzheimer’s disease.•Principal components reflect spatial patterns of covariance in synaptic density.•Principal components are correlated with unique characteristics in Alzheimer’s disease.•These findings support synaptic density as a robust biomarker of disease severity.
Synaptic loss is considered an early pathological event and major structural correlate of cognitive impairment in Alzheimer’s disease (AD). We used principal component analysis (PCA) to identify regional patterns of covariance in synaptic density using [11C]UCB-J PET and assessed the association between principal components (PC) subject scores with cognitive performance.
[11C]UCB-J binding was measured in 45 amyloid + participants with AD and 19 amyloid– cognitively normal participants aged 55–85. A validated neuropsychological battery assessed performance across five cognitive domains. PCA was applied to the pooled sample using distribution volume ratios (DVR) standardized (z-scored) by region from 42 bilateral regions of interest (ROI).
Parallel analysis determined three significant PCs explaining 70.2% of the total variance. PC1 was characterized by positive loadings with similar contributions across the majority of ROIs. PC2 was characterized by positive and negative loadings with strongest contributions from subcortical and parietooccipital cortical regions, respectively, while PC3 was characterized by positive and negative loadings with strongest contributions from rostral and caudal cortical regions, respectively. Within the AD group, PC1 subject scores were positively correlated with performance across all cognitive domains (Pearson r = 0.24–0.40, P = 0.06–0.006), PC2 subject scores were inversely correlated with age (Pearson r = -0.45, P = 0.002) and PC3 subject scores were significantly correlated with CDR-sb (Pearson r = 0.46, P = 0.04). No significant correlations were observed between cognitive performance and PC subject scores in CN participants.
This data-driven approach defined specific spatial patterns of synaptic density correlated with unique participant characteristics within the AD group. Our findings reinforce synaptic density as a robust biomarker of disease presence and severity in the early stages of AD. |
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| AbstractList | Synaptic loss is considered an early pathological event and major structural correlate of cognitive impairment in Alzheimer's disease (AD). We used principal component analysis (PCA) to identify regional patterns of covariance in synaptic density using [
C]UCB-J PET and assessed the association between principal components (PC) subject scores with cognitive performance.
[
C]UCB-J binding was measured in 45 amyloid + participants with AD and 19 amyloid- cognitively normal participants aged 55-85. A validated neuropsychological battery assessed performance across five cognitive domains. PCA was applied to the pooled sample using distribution volume ratios (DVR) standardized (z-scored) by region from 42 bilateral regions of interest (ROI).
Parallel analysis determined three significant PCs explaining 70.2% of the total variance. PC1 was characterized by positive loadings with similar contributions across the majority of ROIs. PC2 was characterized by positive and negative loadings with strongest contributions from subcortical and parietooccipital cortical regions, respectively, while PC3 was characterized by positive and negative loadings with strongest contributions from rostral and caudal cortical regions, respectively. Within the AD group, PC1 subject scores were positively correlated with performance across all cognitive domains (Pearson r = 0.24-0.40, P = 0.06-0.006), PC2 subject scores were inversely correlated with age (Pearson r = -0.45, P = 0.002) and PC3 subject scores were significantly correlated with CDR-sb (Pearson r = 0.46, P = 0.04). No significant correlations were observed between cognitive performance and PC subject scores in CN participants.
This data-driven approach defined specific spatial patterns of synaptic density correlated with unique participant characteristics within the AD group. Our findings reinforce synaptic density as a robust biomarker of disease presence and severity in the early stages of AD. Background: Synaptic loss is considered an early pathological event and major structural correlate of cognitive impairment in Alzheimer’s disease (AD). We used principal component analysis (PCA) to identify regional patterns of covariance in synaptic density using [11C]UCB-J PET and assessed the association between principal components (PC) subject scores with cognitive performance. Methods: [11C]UCB-J binding was measured in 45 amyloid + participants with AD and 19 amyloid– cognitively normal participants aged 55–85. A validated neuropsychological battery assessed performance across five cognitive domains. PCA was applied to the pooled sample using distribution volume ratios (DVR) standardized (z-scored) by region from 42 bilateral regions of interest (ROI). Results: Parallel analysis determined three significant PCs explaining 70.2% of the total variance. PC1 was characterized by positive loadings with similar contributions across the majority of ROIs. PC2 was characterized by positive and negative loadings with strongest contributions from subcortical and parietooccipital cortical regions, respectively, while PC3 was characterized by positive and negative loadings with strongest contributions from rostral and caudal cortical regions, respectively. Within the AD group, PC1 subject scores were positively correlated with performance across all cognitive domains (Pearson r = 0.24–0.40, P = 0.06–0.006), PC2 subject scores were inversely correlated with age (Pearson r = -0.45, P = 0.002) and PC3 subject scores were significantly correlated with CDR-sb (Pearson r = 0.46, P = 0.04). No significant correlations were observed between cognitive performance and PC subject scores in CN participants. Conclusions: This data-driven approach defined specific spatial patterns of synaptic density correlated with unique participant characteristics within the AD group. Our findings reinforce synaptic density as a robust biomarker of disease presence and severity in the early stages of AD. Highlights•This is the first application of PCA to synaptic density PET in Alzheimer’s disease. •Principal components reflect spatial patterns of covariance in synaptic density. •Principal components are correlated with unique characteristics in Alzheimer’s disease. •These findings support synaptic density as a robust biomarker of disease severity. • This is the first application of PCA to synaptic density PET in Alzheimer’s disease. • Principal components reflect spatial patterns of covariance in synaptic density. • Principal components are correlated with unique characteristics in Alzheimer’s disease. • These findings support synaptic density as a robust biomarker of disease severity. •This is the first application of PCA to synaptic density PET in Alzheimer’s disease.•Principal components reflect spatial patterns of covariance in synaptic density.•Principal components are correlated with unique characteristics in Alzheimer’s disease.•These findings support synaptic density as a robust biomarker of disease severity. Synaptic loss is considered an early pathological event and major structural correlate of cognitive impairment in Alzheimer’s disease (AD). We used principal component analysis (PCA) to identify regional patterns of covariance in synaptic density using [11C]UCB-J PET and assessed the association between principal components (PC) subject scores with cognitive performance. [11C]UCB-J binding was measured in 45 amyloid + participants with AD and 19 amyloid– cognitively normal participants aged 55–85. A validated neuropsychological battery assessed performance across five cognitive domains. PCA was applied to the pooled sample using distribution volume ratios (DVR) standardized (z-scored) by region from 42 bilateral regions of interest (ROI). Parallel analysis determined three significant PCs explaining 70.2% of the total variance. PC1 was characterized by positive loadings with similar contributions across the majority of ROIs. PC2 was characterized by positive and negative loadings with strongest contributions from subcortical and parietooccipital cortical regions, respectively, while PC3 was characterized by positive and negative loadings with strongest contributions from rostral and caudal cortical regions, respectively. Within the AD group, PC1 subject scores were positively correlated with performance across all cognitive domains (Pearson r = 0.24–0.40, P = 0.06–0.006), PC2 subject scores were inversely correlated with age (Pearson r = -0.45, P = 0.002) and PC3 subject scores were significantly correlated with CDR-sb (Pearson r = 0.46, P = 0.04). No significant correlations were observed between cognitive performance and PC subject scores in CN participants. This data-driven approach defined specific spatial patterns of synaptic density correlated with unique participant characteristics within the AD group. Our findings reinforce synaptic density as a robust biomarker of disease presence and severity in the early stages of AD. |
| ArticleNumber | 103457 |
| Author | Lu, Yihuan Nabulsi, Nabeel B. Salardini, Elaheh Zhao, Wenzhen Toyonaga, Takuya Arnsten, Amy F.T. Gupta, Dhruva Naganawa, Mika Ni, Gessica Chen, Ming-Kai Carson, Richard E. Chupak, Anna van Dyck, Christopher H. Huang, Yiyun Higgins-Chen, Albert Mecca, Adam P. O'Dell, Ryan S. |
| Author_xml | – sequence: 1 givenname: Ryan S. surname: O'Dell fullname: O'Dell, Ryan S. email: ryan.odell@yale.edu organization: Alzheimer’s Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT 06510, USA – sequence: 2 givenname: Albert surname: Higgins-Chen fullname: Higgins-Chen, Albert organization: Alzheimer’s Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT 06510, USA – sequence: 3 givenname: Dhruva surname: Gupta fullname: Gupta, Dhruva organization: Alzheimer’s Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT 06510, USA – sequence: 4 givenname: Ming-Kai surname: Chen fullname: Chen, Ming-Kai organization: Department of Radiology and Biomedical Imaging, Yale University School of Medicine, P.O. Box 208048, New Haven, CT 06520, USA – sequence: 5 givenname: Mika surname: Naganawa fullname: Naganawa, Mika organization: Department of Radiology and Biomedical Imaging, Yale University School of Medicine, P.O. Box 208048, New Haven, CT 06520, USA – sequence: 6 givenname: Takuya surname: Toyonaga fullname: Toyonaga, Takuya organization: Department of Radiology and Biomedical Imaging, Yale University School of Medicine, P.O. Box 208048, New Haven, CT 06520, USA – sequence: 7 givenname: Yihuan surname: Lu fullname: Lu, Yihuan organization: Department of Radiology and Biomedical Imaging, Yale University School of Medicine, P.O. Box 208048, New Haven, CT 06520, USA – sequence: 8 givenname: Gessica surname: Ni fullname: Ni, Gessica organization: Alzheimer’s Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT 06510, USA – sequence: 9 givenname: Anna surname: Chupak fullname: Chupak, Anna organization: Alzheimer’s Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT 06510, USA – sequence: 10 givenname: Wenzhen surname: Zhao fullname: Zhao, Wenzhen organization: Alzheimer’s Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT 06510, USA – sequence: 11 givenname: Elaheh surname: Salardini fullname: Salardini, Elaheh organization: Alzheimer’s Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT 06510, USA – sequence: 12 givenname: Nabeel B. surname: Nabulsi fullname: Nabulsi, Nabeel B. organization: Department of Radiology and Biomedical Imaging, Yale University School of Medicine, P.O. Box 208048, New Haven, CT 06520, USA – sequence: 13 givenname: Yiyun surname: Huang fullname: Huang, Yiyun organization: Department of Radiology and Biomedical Imaging, Yale University School of Medicine, P.O. Box 208048, New Haven, CT 06520, USA – sequence: 14 givenname: Amy F.T. surname: Arnsten fullname: Arnsten, Amy F.T. organization: Department of Neuroscience, Yale University School of Medicine, P.O. Box 208001, New Haven, CT 06520, USA – sequence: 15 givenname: Richard E. surname: Carson fullname: Carson, Richard E. organization: Department of Radiology and Biomedical Imaging, Yale University School of Medicine, P.O. Box 208048, New Haven, CT 06520, USA – sequence: 16 givenname: Christopher H. surname: van Dyck fullname: van Dyck, Christopher H. organization: Alzheimer’s Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT 06510, USA – sequence: 17 givenname: Adam P. surname: Mecca fullname: Mecca, Adam P. email: adam.mecca@yale.edu organization: Alzheimer’s Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT 06510, USA |
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| Cites_doi | 10.1186/s13195-020-00742-y 10.1016/j.neurobiolaging.2005.09.012 10.1006/neur.1996.0056 10.1016/j.neurobiolaging.2017.09.027 10.1093/cercor/bhn113 10.1016/j.jalz.2011.03.005 10.1016/j.neurobiolaging.2021.11.004 10.1126/science.1074069 10.2967/jnumed.118.219097 10.1177/0271678X17724947 10.1002/mds.28188 10.1016/j.neuroimage.2012.01.021 10.2967/jnumed.120.252783 10.2967/jnumed.115.168179 10.1212/WNL.0000000000012969 10.1002/alz.12582 10.2967/jnumed.119.230797 10.1002/ana.410270502 10.1212/01.wnl.0000260698.46517.8f 10.1097/01.WCB.0000033967.83623.34 10.1016/j.jalz.2015.12.005 10.1002/mds.21933 10.1093/brain/awu256 10.1073/pnas.0900345106 10.1126/scitranslmed.aaf6667 10.1177/0271678X211004312 10.1002/mds.28617 10.1002/alz.12097 10.1016/0304-3940(94)90121-X 10.1126/scitranslmed.aau5732 10.1186/s13195-020-00647-w 10.1177/0271678X19879230 10.1007/s11307-019-01387-6 10.1186/s13195-020-0582-0 10.1016/j.neurobiolaging.2007.06.010 10.1523/JNEUROSCI.1174-16.2016 10.1002/acn3.51407 10.1088/0031-9155/57/21/R119 10.1038/sj.jcbfm.9600358 10.1038/tp.2011.27 10.1016/j.neuroimage.2008.01.056 10.1001/jamaneurol.2018.1836 10.1118/1.4819820 10.1088/0031-9155/52/5/019 10.1007/s00259-008-0869-z 10.1016/j.jalz.2011.03.008 10.1007/s00259-019-04461-x 10.1212/WNL.0000000000009818 10.2174/156720501108140910114230 10.1186/s13195-021-00772-0 10.1212/WNL.0000000000003285 10.1002/mds.28216 10.1016/j.bcp.2013.12.028 |
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| Keywords | DVR LMII MRI PiB Synaptic density CDR Aβ SD [11C]UCB-J SV2A MMSE GDS APOE BPND WAIS aMCI 1TC SRTM2 AD Alzheimer’s disease GM CN RAVLT ROI PCA CS IY PCC CDR-SB PC FWHM PVC Positron emission tomography PET VT Principal component analysis Cb V T principal component BP ND synaptic vesicle glycoprotein 2A full width half maximum Wechsler Adult Intelligence Scale Geriatric depression scale partial volume correction amyloid-β Iterative Yang apolipoprotein E Clinical Dementia Rating Scale Mini-Mental Status Exam [ 11C]UCB-J standard deviation magnetic resonance imaging cerebellum simplified reference tissue model – 2 step 1 tissue compartment Pittsburgh Compound B posterior cingulate cortex distribution volume ratio Rey Auditory Verbal Learning Test centrum semiovale CDR-sum of boxes Logical Memory II binding potential non-displaceable gray matter region of interest volume of distribution (total) cognitively normal amnestic mild cognitive impairment [C]UCB-J |
| Language | English |
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| References | Mertens, Maguire, Serdons, Lacroix, Mercier, Sciberras, Van Laere, Koole (b0195) 2020; 22 Coomans, Schoonhoven, Tuncel, Verfaillie, Wolters, Boellaard, Ossenkoppele, den Braber, Scheper, Schober, Sweeney, Ryan, Schuit, Windhorst, Barkhof, Scheltens, Golla, Hillebrand, Gouw, van Berckel (b0055) 2021; 13 Bastin, Bahri, Meyer, Manard, Delhaye, Plenevaux, Becker, Seret, Mella, Giacomelli, Degueldre, Balteau, Luxen, Salmon (b0015) 2020; 47 Nabulsi, Mercier, Holden, Carré, Najafzadeh, Vandergeten, Lin, Deo, Price, Wood, Lara-Jaime, Montel, Laruelle, Carson, Hannestad, Huang (b0200) 2016; 57 Andersen, Hansen, Damholdt, Horsager, Skjaerbaek, Gottrup (b0010) 2021; 36 Holland, Jones, Savulich, Wiggins, Hong, Fryer (b0125) 2020; 35 Ma, Tang, Spetsieris, Dhawan, Eidelberg (b0145) 2007; 27 Chen, Mecca, Naganawa, Gallezot, Toyonaga, Mondal, Finnema, Lin, O’Dell, McDonald, Michalak, Vander Wyk, Nabulsi, Huang, Arnsten, van Dyck, Carson (b0050) 2021; 41 DeKosky, Scheff, Styren (b0075) 1996; 5 Niethammer, Tang, Feigin, Allen, Heinen, Hellwig, Amtage, Hanspal, Vonsattel, Poston, Meyer, Leenders, Eidelberg (b0205) 2014; 137 Bott, Héraud, Cosquer, Herbeaux, Aubert, Sartori, Goutagny, Mathis (b0035) 2016; 36 Lu, Toyonaga, Naganawa, Gallezot, Chen, Mecca (b0140) 2018; 59 Dickerson, Bakkour, Salat, Feczko, Pacheco, Greve, Grodstein, Wright, Blacker, Rosas, Sperling, Atri, Growdon, Hyman, Morris, Fischl, Buckner (b0090) 2009; 19 Mattis, Niethammer, Sako, Tang, Nazem, Gordon, Brandt, Dhawan, Eidelberg (b0160) 2016; 87 Albert, DeKosky, Dickson, Dubois, Feldman, Fox, Gamst, Holtzman, Jagust, Petersen, Snyder, Carrillo, Thies, Phelps (b0005) 2011; 7 DeKosky, Scheff (b0070) 1990; 27 Fischl (b0115) 2012; 62 Masliah, Mallory, Hansen, DeTeresa, Alford, Terry (b0155) 1994; 174 Wu, Carson (b0280) 2002; 22 Delva, Van Weehaeghe, Koole, Van Laere, Vandenberghe (b0080) 2020; 35 Williams, Storandt, Roe, Morris (b0275) 2013; 9 Malpetti, Holland, Jones, Ye, Cope, Fryer, Hong, Savulich, Rittman, Passamonti, Mak, Aigbirhio, O’Brien, Rowe (b0150) 2021; 8 Selkoe (b0255) 2002; 298 McKhann, Knopman, Chertkow, Hyman, Jack, Kawas, Klunk, Koroshetz, Manly, Mayeux, Mohs, Morris, Rossor, Scheltens, Carrillo, Thies, Weintraub, Phelps (b0165) 2011; 7 Teune, Strijkert, Renken, Izaks, de Vries, Segbers (b0265) 2014; 11 Eckert, Tang, Ma, Brown, Lin, Frucht, Feigin, Eidelberg (b0095) 2008; 23 Mecca, McDonald, Michalak, Godek, Harris, Pugh, Kemp, Chen, Salardini, Nabulsi, Lim, Huang, Carson, Strittmatter, van Dyck (b0180) 2020; 12 Mecca, Chen, O'Dell, Naganawa, Toyonaga, Godek, Harris, Bartlett, Zhao, Nabulsi, Wyk, Varma, Arnsten, Huang, Carson, Dyck (b0175) 2020; 16 Chen, Mecca, Naganawa, Finnema, Toyonaga, Lin, Najafzadeh, Ropchan, Lu, McDonald, Michalak, Nabulsi, Arnsten, Huang, Carson, van Dyck (b0045) 2018; 75 Salmon, Kerrouche, Perani, Lekeu, Holthoff, Beuthien-Baumann, Sorbi, Lemaire, Collette, Herholz (b0235) 2009; 30 Finnema, Nabulsi, Mercier, Lin, Chen, Matuskey, Gallezot, Henry, Hannestad, Huang, Carson (b0110) 2018; 38 Rao, Rapoport, Kim (b0220) 2011; 1 de Jong, van Velden, Kloet, Buijs, Boellaard, Lammertsma (b0060) 2007; 52 Blazhenets, Ma, Sörensen, Schiller, Rücker, Eidelberg, Frings, Meyer (b0025) 2020; 61 Nobili, Salmaso, Morbelli, Girtler, Piccardo, Brugnolo, Dessi, Larsson, Rodriguez, Pagani (b0210) 2008; 35 Scheff, Price, Schmitt, Mufson (b0240) 2006; 27 Scheff, Price, Schmitt, DeKosky, Mufson (b0245) 2007; 68 Stage, Svaldi, Phillips, Canela, Duran, Goukasian, Risacher, Saykin, Apostolova (b0260) 2020; 12 Erlandsson, Buvat, Pretorius, Thomas, Hutton (b0100) 2012; 57 Mecca, O’Dell, Sharp, Banks, Bartlett, Zhao, Lipior, Diepenbrock, Chen, Naganawa, Toyonaga, Nabulsi, Wyk, Arnsten, Huang, Carson, van Dyck (b0190) 2022; 18 Finnema, Nabulsi, Eid, Detyniecki, Lin, Chen, Dhaher, Matuskey, Baum, Holden, Spencer, Mercier, Hannestad, Huang, Carson (b0105) 2016; 8 La Joie, Visani, Baker, Brown, Bourakova, Cha, Chaudhary, Edwards, Iaccarino, Janabi, Lesman-Segev, Miller, Perry, O’Neil, Pham, Rojas, Rosen, Seeley, Tsai, Miller, Jagust, Rabinovici (b0135) 2020; 12 Scheff, Neltner, Nelson (b0250) 2014; 88 Blazhenets, Ma, Sörensen, Rücker, Schiller, Eidelberg, Frings, Meyer (b0020) 2019; 60 Rossano, Toyonaga, Finnema, Naganawa, Lu, Nabulsi, Ropchan, De Bruyn, Otoul, Stockis, Nicolas, Martin, Mercier, Huang, Maguire, Carson (b0230) 2020; 40 Jin, Mulnix, Gallezot, Carson (b0130) 2013; 40 O'Dell, Mecca, Chen, Naganawa, Toyonaga, Lu (b0215) 2021; 13 Habeck, Foster, Perneczky, Kurz, Alexopoulos, Koeppe, Drzezga, Stern (b0120) 2008; 40 Delva, Michiels, Koole, Van Laere, Vandenberghe (b0085) 2022; 98 Vanhaute, Ceccarini, Michiels, Koole, Sunaert, Lemmens, Triau, Emsell, Vandenbulcke, Van Laere (b0270) 2020; 95 Carson, R., Barker, W., Liow, J., Adler S., Johnson, C. (Eds.), 2003. Design of a motion-compensation OSEM list-mode algorithm for resolution-recovery reconstruction of the HRRT. IEEE Nuclear Sciences Symposium; Portland, OR, USA. Mecca, Chen, O'Dell, Naganawa, Toyonaga, Godek, Harris, Bartlett, Zhao, Banks, Ni, Rogers, Gallezot, Ropchan, Emery, Nabulsi, Vander Wyk, Arnsten, Huang, Carson, van Dyck (b0185) 2022; 111 Reiman, Chen, Liu, Bandy, Yu, Lee (b0225) 2009; 106 Blazhenets, Frings, Sorensen, Meyer, Alzheimer's Disease Neuroimaging (b0030) 2021; 62 de Wilde, Overk, Sijben, Masliah (b0065) 2016; 12 Mecca, Barcelos, Wang, Bruck, Nabulsi, Planeta-Wilson (b0170) 2018; 61 Mertens (10.1016/j.nicl.2023.103457_b0195) 2020; 22 Lu (10.1016/j.nicl.2023.103457_b0140) 2018; 59 Mattis (10.1016/j.nicl.2023.103457_b0160) 2016; 87 Wu (10.1016/j.nicl.2023.103457_b0280) 2002; 22 Dickerson (10.1016/j.nicl.2023.103457_b0090) 2009; 19 Mecca (10.1016/j.nicl.2023.103457_b0175) 2020; 16 Mecca (10.1016/j.nicl.2023.103457_b0180) 2020; 12 Williams (10.1016/j.nicl.2023.103457_b0275) 2013; 9 Chen (10.1016/j.nicl.2023.103457_b0045) 2018; 75 Mecca (10.1016/j.nicl.2023.103457_b0190) 2022; 18 DeKosky (10.1016/j.nicl.2023.103457_b0075) 1996; 5 Mecca (10.1016/j.nicl.2023.103457_b0170) 2018; 61 Scheff (10.1016/j.nicl.2023.103457_b0250) 2014; 88 Scheff (10.1016/j.nicl.2023.103457_b0245) 2007; 68 Andersen (10.1016/j.nicl.2023.103457_b0010) 2021; 36 10.1016/j.nicl.2023.103457_b0040 Nobili (10.1016/j.nicl.2023.103457_b0210) 2008; 35 McKhann (10.1016/j.nicl.2023.103457_b0165) 2011; 7 de Jong (10.1016/j.nicl.2023.103457_b0060) 2007; 52 Albert (10.1016/j.nicl.2023.103457_b0005) 2011; 7 Masliah (10.1016/j.nicl.2023.103457_b0155) 1994; 174 Vanhaute (10.1016/j.nicl.2023.103457_b0270) 2020; 95 Blazhenets (10.1016/j.nicl.2023.103457_b0020) 2019; 60 Blazhenets (10.1016/j.nicl.2023.103457_b0025) 2020; 61 Erlandsson (10.1016/j.nicl.2023.103457_b0100) 2012; 57 Habeck (10.1016/j.nicl.2023.103457_b0120) 2008; 40 Fischl (10.1016/j.nicl.2023.103457_b0115) 2012; 62 Holland (10.1016/j.nicl.2023.103457_b0125) 2020; 35 Jin (10.1016/j.nicl.2023.103457_b0130) 2013; 40 Rossano (10.1016/j.nicl.2023.103457_b0230) 2020; 40 Malpetti (10.1016/j.nicl.2023.103457_b0150) 2021; 8 Nabulsi (10.1016/j.nicl.2023.103457_b0200) 2016; 57 Rao (10.1016/j.nicl.2023.103457_b0220) 2011; 1 Salmon (10.1016/j.nicl.2023.103457_b0235) 2009; 30 Selkoe (10.1016/j.nicl.2023.103457_b0255) 2002; 298 Teune (10.1016/j.nicl.2023.103457_b0265) 2014; 11 Finnema (10.1016/j.nicl.2023.103457_b0110) 2018; 38 Blazhenets (10.1016/j.nicl.2023.103457_b0030) 2021; 62 Eckert (10.1016/j.nicl.2023.103457_b0095) 2008; 23 DeKosky (10.1016/j.nicl.2023.103457_b0070) 1990; 27 Scheff (10.1016/j.nicl.2023.103457_b0240) 2006; 27 Delva (10.1016/j.nicl.2023.103457_b0085) 2022; 98 de Wilde (10.1016/j.nicl.2023.103457_b0065) 2016; 12 Ma (10.1016/j.nicl.2023.103457_b0145) 2007; 27 Stage (10.1016/j.nicl.2023.103457_b0260) 2020; 12 Mecca (10.1016/j.nicl.2023.103457_b0185) 2022; 111 Niethammer (10.1016/j.nicl.2023.103457_b0205) 2014; 137 O'Dell (10.1016/j.nicl.2023.103457_b0215) 2021; 13 Reiman (10.1016/j.nicl.2023.103457_b0225) 2009; 106 Delva (10.1016/j.nicl.2023.103457_b0080) 2020; 35 Bastin (10.1016/j.nicl.2023.103457_b0015) 2020; 47 Chen (10.1016/j.nicl.2023.103457_b0050) 2021; 41 Coomans (10.1016/j.nicl.2023.103457_b0055) 2021; 13 Finnema (10.1016/j.nicl.2023.103457_b0105) 2016; 8 La Joie (10.1016/j.nicl.2023.103457_b0135) 2020; 12 Bott (10.1016/j.nicl.2023.103457_b0035) 2016; 36 |
| References_xml | – volume: 111 start-page: 44 year: 2022 end-page: 53 ident: b0185 article-title: Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease publication-title: Neurobiol. Aging – reference: Carson, R., Barker, W., Liow, J., Adler S., Johnson, C. (Eds.), 2003. Design of a motion-compensation OSEM list-mode algorithm for resolution-recovery reconstruction of the HRRT. IEEE Nuclear Sciences Symposium; Portland, OR, USA. – volume: 41 start-page: 2395 year: 2021 end-page: 2409 ident: b0050 article-title: Comparison of [(11)C]UCB-J and [(18)F]FDG PET in Alzheimer's disease: a tracer kinetic modeling study publication-title: J. Cereb. Blood Flow Metab. – volume: 174 start-page: 67 year: 1994 end-page: 72 ident: b0155 article-title: Synaptic and neuritic alterations during the progression of Alzheimer's disease publication-title: Neurosci. Lett. – volume: 1 start-page: e31 year: 2011 ident: b0220 article-title: Altered neuroinflammatory, arachidonic acid cascade and synaptic markers in postmortem Alzheimer's disease brain publication-title: Transl. Psychiatry – volume: 61 start-page: 597 year: 2020 end-page: 603 ident: b0025 article-title: Predictive value of (18)F-florbetapir and (18)F-FDG PET for conversion from mild cognitive impairment to alzheimer dementia publication-title: J. Nucl. Med. – volume: 27 start-page: 1372 year: 2006 end-page: 1384 ident: b0240 article-title: Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment publication-title: Neurobiol. Aging – volume: 12 year: 2020 ident: b0260 article-title: Neurodegenerative changes in early- and late-onset cognitive impairment with and without brain amyloidosis publication-title: Alzheimers Res. Ther. – volume: 19 start-page: 497 year: 2009 end-page: 510 ident: b0090 article-title: The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals publication-title: Cereb. Cortex – volume: 5 start-page: 417 year: 1996 end-page: 421 ident: b0075 article-title: Structural correlates of cognition in dementia: quantification and assessment of synapse change publication-title: Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration – volume: 137 start-page: 3036 year: 2014 end-page: 3046 ident: b0205 article-title: A disease-specific metabolic brain network associated with corticobasal degeneration publication-title: Brain – volume: 9 start-page: S39 year: 2013 end-page: S44 ident: b0275 article-title: Progression of alzheimer's disease as measured by clinical dementia rating sum of boxes scores publication-title: Alzheimers Dement. – volume: 62 start-page: 855 year: 2021 end-page: 860 ident: b0030 article-title: Principal-component analysis-based measures of PET data closely reflect neuropathologic staging schemes publication-title: J. Nucl. Med. – volume: 35 start-page: 2191 year: 2008 end-page: 2202 ident: b0210 article-title: Principal component analysis of FDG PET in amnestic MCI publication-title: Eur. J. Nucl. Med. Mol. Imaging – volume: 12 year: 2020 ident: b0180 article-title: PET imaging of mGluR5 in Alzheimer's disease publication-title: Alzheimers Res. Ther. – volume: 30 start-page: 186 year: 2009 end-page: 197 ident: b0235 article-title: On the multivariate nature of brain metabolic impairment in Alzheimer's disease publication-title: Neurobiol. Aging – volume: 60 start-page: 837 year: 2019 end-page: 843 ident: b0020 article-title: Principal components analysis of brain metabolism predicts development of alzheimer dementia publication-title: J. Nucl. Med. – volume: 40 year: 2013 ident: b0130 article-title: Evaluation of motion correction methods in human brain PET imaging–a simulation study based on human motion data publication-title: Med. Phys. – volume: 88 start-page: 517 year: 2014 end-page: 528 ident: b0250 article-title: Is synaptic loss a unique hallmark of Alzheimer's disease? publication-title: Biochem. Pharmacol. – volume: 12 year: 2020 ident: b0135 article-title: Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET publication-title: Sci. Transl. Med. – volume: 13 year: 2021 ident: b0055 article-title: In vivo tau pathology is associated with synaptic loss and altered synaptic function publication-title: Alzheimers Res. Ther. – volume: 23 start-page: 727 year: 2008 end-page: 733 ident: b0095 article-title: Abnormal metabolic networks in atypical parkinsonism publication-title: Mov. Disord. – volume: 8 start-page: 1515 year: 2021 end-page: 1523 ident: b0150 article-title: Synaptic density in carriers of C9orf72 mutations: a [(11) C]UCB-J PET study publication-title: Ann. Clin. Transl. Neurol. – volume: 52 start-page: 1505 year: 2007 end-page: 1526 ident: b0060 article-title: Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner publication-title: Phys. Med. Biol. – volume: 36 start-page: 10472 year: 2016 end-page: 10486 ident: b0035 article-title: APOE-sensitive cholinergic sprouting compensates for hippocampal dysfunctions due to reduced entorhinal input publication-title: J. Neurosci. – volume: 75 start-page: 1215 year: 2018 ident: b0045 article-title: Assessing synaptic density in alzheimer disease with synaptic vesicle glycoprotein 2A positron emission tomographic imaging publication-title: JAMA Neurol. – volume: 40 start-page: 1503 year: 2008 end-page: 1515 ident: b0120 article-title: Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease publication-title: Neuroimage – volume: 35 start-page: 1834 year: 2020 end-page: 1842 ident: b0125 article-title: Synaptic loss in primary tauopathies revealed by [(11) C]UCB-J positron emission tomography publication-title: Mov. Disord. – volume: 298 start-page: 789 year: 2002 end-page: 791 ident: b0255 article-title: Alzheimer's disease is a synaptic failure publication-title: Science – volume: 47 start-page: 390 year: 2020 end-page: 402 ident: b0015 article-title: In vivo imaging of synaptic loss in Alzheimer's disease with [18F]UCB-H positron emission tomography publication-title: Eur. J. Nucl. Med. Mol. Imaging – volume: 22 start-page: 1440 year: 2002 end-page: 1452 ident: b0280 article-title: Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging publication-title: J. Cereb. Blood Flow Metab. – volume: 7 start-page: 270 year: 2011 end-page: 279 ident: b0005 article-title: The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement. – volume: 8 year: 2016 ident: b0105 article-title: Imaging synaptic density in the living human brain publication-title: Sci. Transl. Med. – volume: 16 start-page: 974 year: 2020 end-page: 982 ident: b0175 article-title: In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET publication-title: Alzheimers Dement. – volume: 36 start-page: 2057 year: 2021 end-page: 2065 ident: b0010 article-title: Reduced synaptic density in patients with lewy body dementia: an [(11) C]UCB-J PET imaging study publication-title: Mov. Disord. – volume: 40 start-page: 1890 year: 2020 end-page: 1901 ident: b0230 article-title: Assessment of a white matter reference region for (11)C-UCB-J PET quantification publication-title: J. Cereb. Blood Flow Metab. – volume: 57 start-page: 777 year: 2016 end-page: 784 ident: b0200 article-title: Synthesis and preclinical evaluation of 11C-UCB-J as a PET tracer for imaging the synaptic vesicle glycoprotein 2A in the brain publication-title: J. Nucl. Med. – volume: 35 start-page: 1977 year: 2020 end-page: 1986 ident: b0080 article-title: Loss of presynaptic terminal integrity in the substantia nigra in early parkinson's disease publication-title: Mov. Disord. – volume: 106 start-page: 6820 year: 2009 end-page: 6825 ident: b0225 article-title: Fibrillar amyloid-{beta} burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease publication-title: PNAS – volume: 57 start-page: R119 year: 2012 end-page: R159 ident: b0100 article-title: A review of partial volume correction techniques for emission tomography and their applications in neurology, cardiology and oncology publication-title: Phys. Med. Biol. – volume: 12 start-page: 633 year: 2016 end-page: 644 ident: b0065 article-title: Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability publication-title: Alzheimers Dement. – volume: 87 start-page: 1925 year: 2016 end-page: 1933 ident: b0160 article-title: Distinct brain networks underlie cognitive dysfunction in Parkinson and Alzheimer diseases publication-title: Neurology – volume: 7 start-page: 263 year: 2011 end-page: 269 ident: b0165 article-title: The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement. – volume: 95 start-page: e545 year: 2020 end-page: e553 ident: b0270 article-title: In vivo synaptic density loss is related to tau deposition in amnestic mild cognitive impairment publication-title: Neurology – volume: 61 start-page: 207 year: 2018 end-page: 214 ident: b0170 article-title: Cortical beta-amyloid burden, gray matter, and memory in adults at varying APOE epsilon4 risk for Alzheimer's disease publication-title: Neurobiol. Aging – volume: 22 start-page: 444 year: 2020 end-page: 452 ident: b0195 article-title: Validation of parametric methods for [(11)C]UCB-J PET imaging using subcortical white matter as reference tissue publication-title: Molecular Imaging and Biology : MIB : The Official Publication of the Academy of Molecular Imaging – volume: 68 start-page: 1501 year: 2007 end-page: 1508 ident: b0245 article-title: Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment publication-title: Neurology – volume: 11 start-page: 725 year: 2014 end-page: 732 ident: b0265 article-title: The Alzheimer's disease-related glucose metabolic brain pattern publication-title: Curr. Alzheimer Res. – volume: 27 start-page: 597 year: 2007 end-page: 605 ident: b0145 article-title: Abnormal metabolic network activity in Parkinson's disease: test-retest reproducibility publication-title: J. Cereb. Blood Flow Metab. – volume: 62 start-page: 774 year: 2012 end-page: 781 ident: b0115 article-title: FreeSurfer publication-title: Neuroimage – volume: 59 start-page: 77 year: 2018 ident: b0140 article-title: Partial volume correction for PET synaptic density imaging with 11C-UCB-J publication-title: J. Nucl. Med. – volume: 38 start-page: 2041 year: 2018 end-page: 2052 ident: b0110 article-title: Kinetic evaluation and test-retest reproducibility of [(11)C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans publication-title: J. Cereb. Blood Flow Metab. – volume: 18 start-page: 2527 year: 2022 end-page: 2536 ident: b0190 article-title: Synaptic density and cognitive performance in Alzheimer’s disease: A PET imaging study with [(11)C]UCB-J publication-title: Alzheimers Dement. – volume: 13 start-page: 11 year: 2021 ident: b0215 article-title: Association of Abeta deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [(11)C]UCB-J publication-title: Alzheimers Res. Ther. – volume: 27 start-page: 457 year: 1990 end-page: 464 ident: b0070 article-title: Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity publication-title: Ann. Neurol. – volume: 98 start-page: e83 year: 2022 end-page: e94 ident: b0085 article-title: Synaptic damage and its clinical correlates in people with early huntington disease: a PET study publication-title: Neurology – volume: 13 start-page: 11 issue: 1 year: 2021 ident: 10.1016/j.nicl.2023.103457_b0215 article-title: Association of Abeta deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [(11)C]UCB-J publication-title: Alzheimers Res. Ther. doi: 10.1186/s13195-020-00742-y – volume: 27 start-page: 1372 issue: 10 year: 2006 ident: 10.1016/j.nicl.2023.103457_b0240 article-title: Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2005.09.012 – volume: 5 start-page: 417 issue: 4 year: 1996 ident: 10.1016/j.nicl.2023.103457_b0075 article-title: Structural correlates of cognition in dementia: quantification and assessment of synapse change publication-title: Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration doi: 10.1006/neur.1996.0056 – volume: 61 start-page: 207 year: 2018 ident: 10.1016/j.nicl.2023.103457_b0170 article-title: Cortical beta-amyloid burden, gray matter, and memory in adults at varying APOE epsilon4 risk for Alzheimer's disease publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2017.09.027 – volume: 19 start-page: 497 issue: 3 year: 2009 ident: 10.1016/j.nicl.2023.103457_b0090 article-title: The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals publication-title: Cereb. Cortex doi: 10.1093/cercor/bhn113 – volume: 7 start-page: 263 issue: 3 year: 2011 ident: 10.1016/j.nicl.2023.103457_b0165 article-title: The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2011.03.005 – volume: 111 start-page: 44 year: 2022 ident: 10.1016/j.nicl.2023.103457_b0185 article-title: Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2021.11.004 – ident: 10.1016/j.nicl.2023.103457_b0040 – volume: 298 start-page: 789 issue: 5594 year: 2002 ident: 10.1016/j.nicl.2023.103457_b0255 article-title: Alzheimer's disease is a synaptic failure publication-title: Science doi: 10.1126/science.1074069 – volume: 60 start-page: 837 issue: 6 year: 2019 ident: 10.1016/j.nicl.2023.103457_b0020 article-title: Principal components analysis of brain metabolism predicts development of alzheimer dementia publication-title: J. Nucl. Med. doi: 10.2967/jnumed.118.219097 – volume: 38 start-page: 2041 issue: 11 year: 2018 ident: 10.1016/j.nicl.2023.103457_b0110 article-title: Kinetic evaluation and test-retest reproducibility of [(11)C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans publication-title: J. Cereb. Blood Flow Metab. doi: 10.1177/0271678X17724947 – volume: 35 start-page: 1834 issue: 10 year: 2020 ident: 10.1016/j.nicl.2023.103457_b0125 article-title: Synaptic loss in primary tauopathies revealed by [(11) C]UCB-J positron emission tomography publication-title: Mov. Disord. doi: 10.1002/mds.28188 – volume: 62 start-page: 774 issue: 2 year: 2012 ident: 10.1016/j.nicl.2023.103457_b0115 article-title: FreeSurfer publication-title: Neuroimage doi: 10.1016/j.neuroimage.2012.01.021 – volume: 62 start-page: 855 issue: 6 year: 2021 ident: 10.1016/j.nicl.2023.103457_b0030 article-title: Principal-component analysis-based measures of PET data closely reflect neuropathologic staging schemes publication-title: J. Nucl. Med. doi: 10.2967/jnumed.120.252783 – volume: 57 start-page: 777 issue: 5 year: 2016 ident: 10.1016/j.nicl.2023.103457_b0200 article-title: Synthesis and preclinical evaluation of 11C-UCB-J as a PET tracer for imaging the synaptic vesicle glycoprotein 2A in the brain publication-title: J. Nucl. Med. doi: 10.2967/jnumed.115.168179 – volume: 98 start-page: e83 issue: 1 year: 2022 ident: 10.1016/j.nicl.2023.103457_b0085 article-title: Synaptic damage and its clinical correlates in people with early huntington disease: a PET study publication-title: Neurology doi: 10.1212/WNL.0000000000012969 – volume: 18 start-page: 2527 issue: 12 year: 2022 ident: 10.1016/j.nicl.2023.103457_b0190 article-title: Synaptic density and cognitive performance in Alzheimer’s disease: A PET imaging study with [(11)C]UCB-J publication-title: Alzheimers Dement. doi: 10.1002/alz.12582 – volume: 61 start-page: 597 issue: 4 year: 2020 ident: 10.1016/j.nicl.2023.103457_b0025 article-title: Predictive value of (18)F-florbetapir and (18)F-FDG PET for conversion from mild cognitive impairment to alzheimer dementia publication-title: J. Nucl. Med. doi: 10.2967/jnumed.119.230797 – volume: 27 start-page: 457 issue: 5 year: 1990 ident: 10.1016/j.nicl.2023.103457_b0070 article-title: Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity publication-title: Ann. Neurol. doi: 10.1002/ana.410270502 – volume: 68 start-page: 1501 issue: 18 year: 2007 ident: 10.1016/j.nicl.2023.103457_b0245 article-title: Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment publication-title: Neurology doi: 10.1212/01.wnl.0000260698.46517.8f – volume: 22 start-page: 1440 issue: 12 year: 2002 ident: 10.1016/j.nicl.2023.103457_b0280 article-title: Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging publication-title: J. Cereb. Blood Flow Metab. doi: 10.1097/01.WCB.0000033967.83623.34 – volume: 12 start-page: 633 issue: 6 year: 2016 ident: 10.1016/j.nicl.2023.103457_b0065 article-title: Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2015.12.005 – volume: 23 start-page: 727 issue: 5 year: 2008 ident: 10.1016/j.nicl.2023.103457_b0095 article-title: Abnormal metabolic networks in atypical parkinsonism publication-title: Mov. Disord. doi: 10.1002/mds.21933 – volume: 137 start-page: 3036 issue: 11 year: 2014 ident: 10.1016/j.nicl.2023.103457_b0205 article-title: A disease-specific metabolic brain network associated with corticobasal degeneration publication-title: Brain doi: 10.1093/brain/awu256 – volume: 59 start-page: 77 issue: supplement 1 year: 2018 ident: 10.1016/j.nicl.2023.103457_b0140 article-title: Partial volume correction for PET synaptic density imaging with 11C-UCB-J publication-title: J. Nucl. Med. – volume: 106 start-page: 6820 issue: 16 year: 2009 ident: 10.1016/j.nicl.2023.103457_b0225 article-title: Fibrillar amyloid-{beta} burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease publication-title: PNAS doi: 10.1073/pnas.0900345106 – volume: 8 issue: 348 year: 2016 ident: 10.1016/j.nicl.2023.103457_b0105 article-title: Imaging synaptic density in the living human brain publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaf6667 – volume: 41 start-page: 2395 issue: 9 year: 2021 ident: 10.1016/j.nicl.2023.103457_b0050 article-title: Comparison of [(11)C]UCB-J and [(18)F]FDG PET in Alzheimer's disease: a tracer kinetic modeling study publication-title: J. Cereb. Blood Flow Metab. doi: 10.1177/0271678X211004312 – volume: 36 start-page: 2057 issue: 9 year: 2021 ident: 10.1016/j.nicl.2023.103457_b0010 article-title: Reduced synaptic density in patients with lewy body dementia: an [(11) C]UCB-J PET imaging study publication-title: Mov. Disord. doi: 10.1002/mds.28617 – volume: 16 start-page: 974 issue: 7 year: 2020 ident: 10.1016/j.nicl.2023.103457_b0175 article-title: In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET publication-title: Alzheimers Dement. doi: 10.1002/alz.12097 – volume: 174 start-page: 67 issue: 1 year: 1994 ident: 10.1016/j.nicl.2023.103457_b0155 article-title: Synaptic and neuritic alterations during the progression of Alzheimer's disease publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(94)90121-X – volume: 12 issue: 524 year: 2020 ident: 10.1016/j.nicl.2023.103457_b0135 article-title: Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aau5732 – volume: 12 issue: 1 year: 2020 ident: 10.1016/j.nicl.2023.103457_b0260 article-title: Neurodegenerative changes in early- and late-onset cognitive impairment with and without brain amyloidosis publication-title: Alzheimers Res. Ther. doi: 10.1186/s13195-020-00647-w – volume: 40 start-page: 1890 issue: 9 year: 2020 ident: 10.1016/j.nicl.2023.103457_b0230 article-title: Assessment of a white matter reference region for (11)C-UCB-J PET quantification publication-title: J. Cereb. Blood Flow Metab. doi: 10.1177/0271678X19879230 – volume: 22 start-page: 444 issue: 2 year: 2020 ident: 10.1016/j.nicl.2023.103457_b0195 article-title: Validation of parametric methods for [(11)C]UCB-J PET imaging using subcortical white matter as reference tissue publication-title: Molecular Imaging and Biology : MIB : The Official Publication of the Academy of Molecular Imaging doi: 10.1007/s11307-019-01387-6 – volume: 12 issue: 1 year: 2020 ident: 10.1016/j.nicl.2023.103457_b0180 article-title: PET imaging of mGluR5 in Alzheimer's disease publication-title: Alzheimers Res. Ther. doi: 10.1186/s13195-020-0582-0 – volume: 30 start-page: 186 issue: 2 year: 2009 ident: 10.1016/j.nicl.2023.103457_b0235 article-title: On the multivariate nature of brain metabolic impairment in Alzheimer's disease publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2007.06.010 – volume: 36 start-page: 10472 issue: 40 year: 2016 ident: 10.1016/j.nicl.2023.103457_b0035 article-title: APOE-sensitive cholinergic sprouting compensates for hippocampal dysfunctions due to reduced entorhinal input publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1174-16.2016 – volume: 8 start-page: 1515 issue: 7 year: 2021 ident: 10.1016/j.nicl.2023.103457_b0150 article-title: Synaptic density in carriers of C9orf72 mutations: a [(11) C]UCB-J PET study publication-title: Ann. Clin. Transl. Neurol. doi: 10.1002/acn3.51407 – volume: 57 start-page: R119 issue: 21 year: 2012 ident: 10.1016/j.nicl.2023.103457_b0100 article-title: A review of partial volume correction techniques for emission tomography and their applications in neurology, cardiology and oncology publication-title: Phys. Med. Biol. doi: 10.1088/0031-9155/57/21/R119 – volume: 9 start-page: S39 issue: 1 Suppl year: 2013 ident: 10.1016/j.nicl.2023.103457_b0275 article-title: Progression of alzheimer's disease as measured by clinical dementia rating sum of boxes scores publication-title: Alzheimers Dement. – volume: 27 start-page: 597 issue: 3 year: 2007 ident: 10.1016/j.nicl.2023.103457_b0145 article-title: Abnormal metabolic network activity in Parkinson's disease: test-retest reproducibility publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/sj.jcbfm.9600358 – volume: 1 start-page: e31 issue: 8 year: 2011 ident: 10.1016/j.nicl.2023.103457_b0220 article-title: Altered neuroinflammatory, arachidonic acid cascade and synaptic markers in postmortem Alzheimer's disease brain publication-title: Transl. Psychiatry doi: 10.1038/tp.2011.27 – volume: 40 start-page: 1503 issue: 4 year: 2008 ident: 10.1016/j.nicl.2023.103457_b0120 article-title: Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.01.056 – volume: 75 start-page: 1215 issue: 10 year: 2018 ident: 10.1016/j.nicl.2023.103457_b0045 article-title: Assessing synaptic density in alzheimer disease with synaptic vesicle glycoprotein 2A positron emission tomographic imaging publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2018.1836 – volume: 40 issue: 10 year: 2013 ident: 10.1016/j.nicl.2023.103457_b0130 article-title: Evaluation of motion correction methods in human brain PET imaging–a simulation study based on human motion data publication-title: Med. Phys. doi: 10.1118/1.4819820 – volume: 52 start-page: 1505 issue: 5 year: 2007 ident: 10.1016/j.nicl.2023.103457_b0060 article-title: Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner publication-title: Phys. Med. Biol. doi: 10.1088/0031-9155/52/5/019 – volume: 35 start-page: 2191 issue: 12 year: 2008 ident: 10.1016/j.nicl.2023.103457_b0210 article-title: Principal component analysis of FDG PET in amnestic MCI publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-008-0869-z – volume: 7 start-page: 270 issue: 3 year: 2011 ident: 10.1016/j.nicl.2023.103457_b0005 article-title: The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2011.03.008 – volume: 47 start-page: 390 issue: 2 year: 2020 ident: 10.1016/j.nicl.2023.103457_b0015 article-title: In vivo imaging of synaptic loss in Alzheimer's disease with [18F]UCB-H positron emission tomography publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-019-04461-x – volume: 95 start-page: e545 issue: 5 year: 2020 ident: 10.1016/j.nicl.2023.103457_b0270 article-title: In vivo synaptic density loss is related to tau deposition in amnestic mild cognitive impairment publication-title: Neurology doi: 10.1212/WNL.0000000000009818 – volume: 11 start-page: 725 issue: 8 year: 2014 ident: 10.1016/j.nicl.2023.103457_b0265 article-title: The Alzheimer's disease-related glucose metabolic brain pattern publication-title: Curr. Alzheimer Res. doi: 10.2174/156720501108140910114230 – volume: 13 issue: 1 year: 2021 ident: 10.1016/j.nicl.2023.103457_b0055 article-title: In vivo tau pathology is associated with synaptic loss and altered synaptic function publication-title: Alzheimers Res. Ther. doi: 10.1186/s13195-021-00772-0 – volume: 87 start-page: 1925 issue: 18 year: 2016 ident: 10.1016/j.nicl.2023.103457_b0160 article-title: Distinct brain networks underlie cognitive dysfunction in Parkinson and Alzheimer diseases publication-title: Neurology doi: 10.1212/WNL.0000000000003285 – volume: 35 start-page: 1977 issue: 11 year: 2020 ident: 10.1016/j.nicl.2023.103457_b0080 article-title: Loss of presynaptic terminal integrity in the substantia nigra in early parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.28216 – volume: 88 start-page: 517 issue: 4 year: 2014 ident: 10.1016/j.nicl.2023.103457_b0250 article-title: Is synaptic loss a unique hallmark of Alzheimer's disease? publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2013.12.028 |
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| Snippet | •This is the first application of PCA to synaptic density PET in Alzheimer’s disease.•Principal components reflect spatial patterns of covariance in synaptic... Highlights•This is the first application of PCA to synaptic density PET in Alzheimer’s disease. •Principal components reflect spatial patterns of covariance in... Synaptic loss is considered an early pathological event and major structural correlate of cognitive impairment in Alzheimer's disease (AD). We used principal... • This is the first application of PCA to synaptic density PET in Alzheimer’s disease. • Principal components reflect spatial patterns of covariance in... Background: Synaptic loss is considered an early pathological event and major structural correlate of cognitive impairment in Alzheimer’s disease (AD). We used... |
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| SubjectTerms | [11C]UCB-J Alzheimer Disease - pathology Alzheimer’s disease Amyloid - metabolism Amyloidogenic Proteins - metabolism Brain - pathology Cognitive Dysfunction - pathology Humans Positron emission tomography Principal Component Analysis Radiology Regular SV2A Synaptic density |
| Title | Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease |
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