Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

The bivalent histone modification reader 53BP1 accumulates around DNA double-strand breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end resection. How this function is regulated locally and across the cell cycle to channel repair reactions toward non-homologous end j...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 19; no. 9; pp. 1819 - 1831
Main Authors:	Pellegrino, Stefania, Michelena, Jone, Teloni, Federico, Imhof, Ralph, Altmeyer, Matthias
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 30.05.2017 Elsevier
Subjects:	53BP1 Cell Line, Tumor chromatin Chromatin - metabolism DNA Breaks, Double-Stranded DNA repair DNA Replication DSB repair pathway choice genome stability H4K20 HDR histone methylation Histones - metabolism Humans Lysine - metabolism Models, Biological NHEJ Recombinational DNA Repair Tumor Suppressor p53-Binding Protein 1 - metabolism histone methylation genome stability H4K20 53BP1 HDR HR NHEJ DSB repair pathway choice chromatin DNA repair
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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